CUSABIO

CusaBio

Anti IKBKB mAb (Clone 3E1)

Catalog No.(s): CSB-RA256500A0HU, CSB-RA256500A0HU-50, CSB-RA256500A0HU-100

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK...

CusaBio

Anti DLG4 mAb (Clone 1H4)

Catalog No.(s): CSB-RA255792A0HU, CSB-RA255792A0HU-50, CSB-RA255792A0HU-100

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory...

CusaBio

Anti ID1 mAb (Clone 2C7)

Catalog No.(s): CSB-RA253477A0HU, CSB-RA253477A0HU-50, CSB-RA253477A0HU-100

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in...

CusaBio

Anti BCHE mAb (Clone 1E9)

Catalog No.(s): CSB-RA252650A0HU, CSB-RA252650A0HU-50, CSB-RA252650A0HU-100

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. Product Specifications Application WB, ELISA Reactivity Human Clonality Monoclonal...

CusaBio

Anti FAS mAb (Clone 2B6)

Catalog No.(s): CSB-RA252392A0HU, CSB-RA252392A0HU-50, CSB-RA252392A0HU-100

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases...

CusaBio

Anti IL23A mAb (Clone 1F6)

Catalog No.(s): CSB-RA251959A0HU, CSB-RA251959A0HU-50, CSB-RA251959A0HU-100

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor...

CusaBio

Anti BCL2L1 mAb (Clone 5E9)

Catalog No.(s): CSB-RA247982A0HU, CSB-RA247982A0HU-50, CSB-RA247982A0HU-100

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial...

CusaBio

Anti CD80 mAb (Clone 3C3)

Catalog No.(s): CSB-RA246383A0HU, CSB-RA246383A0HU-50, CSB-RA246383A0HU-100

Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. Product...

CusaBio

Anti MAPT mAb (Clone 4A1)

Catalog No.(s): CSB-RA246354A0HU, CSB-RA246354A0HU-50, CSB-RA246354A0HU-100

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau...

CusaBio

Anti FOXA1 mAb (Clone 3B2)

Catalog No.(s): CSB-RA246102A0HU, CSB-RA246102A0HU-50, CSB-RA246102A0HU-100

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for...

CusaBio

Anti GPA33 mAb (Clone 4H4)

Catalog No.(s): CSB-RA245537A0HU, CSB-RA245537A0HU-50, CSB-RA245537A0HU-100

May play a role in cell-cell recognition and signaling. Product Specifications Application IHC, ELISA Reactivity Human Clonality Monoclonal (Clone No.: 4H4)

CusaBio

Anti CDH2 mAb (Clone 1A9)

Catalog No.(s): CSB-RA243509A0HU, CSB-RA243509A0HU-50, CSB-RA243509A0HU-100

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem...

CusaBio

Anti AR mAb (Clone 10A5)

Catalog No.(s): CSB-RA243116A0HU, CSB-RA243116A0HU-50, CSB-RA243116A0HU-100

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and...

CusaBio

Anti MEN1 mAb (Clone 8G11)

Catalog No.(s): CSB-RA242999A0HU, CSB-RA242999A0HU-50, CSB-RA242999A0HU-100

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression...

CusaBio

Anti ABAT mAb (Clone 5B6)

Catalog No.(s): CSB-RA242969A0HU, CSB-RA242969A0HU-50, CSB-RA242969A0HU-100

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. Product Specifications Application IHC,...

CusaBio

Anti SIN3A mAb (Clone 10G3)

Catalog No.(s): CSB-RA242724A0HU, CSB-RA242724A0HU-50, CSB-RA242724A0HU-100

Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts...

CusaBio

Anti CASP3 mAb (Clone 3H12)

Catalog No.(s): CSB-RA241798A0HU, CSB-RA241798A0HU-50, CSB-RA241798A0HU-100

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element...

CusaBio

Anti PDCD1 mAb (Clone 8E9)

Catalog No.(s): CSB-RA240597A0HU, CSB-RA240597A0HU-50, CSB-RA240597A0HU-100

Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other...

CusaBio

Anti FASN mAb (Clone 2A5)

Catalog No.(s): CSB-RA240595A0HU, CSB-RA240595A0HU-50, CSB-RA240595A0HU-100

Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein. Product Specifications Application IF, FC,...

CusaBio

Anti IL4 mAb (Clone 5D8)

Catalog No.(s): CSB-RA240377A0HU, CSB-RA240377A0HU-50, CSB-RA240377A0HU-100

Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and...

CusaBio

Anti PIK3CB mAb (Clone 5A9)

Catalog No.(s): CSB-RA240122A0HU, CSB-RA240122A0HU-50, CSB-RA240122A0HU-100

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3...

CusaBio

Anti DOT1L mAb (Clone 3B6)

Catalog No.(s): CSB-RA238318A0HU, CSB-RA238318A0HU-50, CSB-RA238318A0HU-100

Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. Product Specifications Application WB, ELISA Reactivity Human Clonality Monoclonal (Clone No.:...

CusaBio

Anti MAPK14 mAb (Clone 2C11)

Catalog No.(s): CSB-RA236860A0HU, CSB-RA236860A0HU-50, CSB-RA236860A0HU-100

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as...

CusaBio

Anti TP53 mAb (Clone 3D4)

Catalog No.(s): CSB-RA236796A0HU, CSB-RA236796A0HU-50, CSB-RA236796A0HU-100

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by...

CusaBio

Anti TXN mAb (Clone 3H8)

Catalog No.(s): CSB-RA233609A0HU, CSB-RA233609A0HU-50, CSB-RA233609A0HU-100

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target...

CusaBio

Anti OGT mAb (Clone 8G7)

Catalog No.(s): CSB-RA232619A0HU, CSB-RA232619A0HU-50, CSB-RA232619A0HU-100

Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and...

CusaBio

Anti DDX5 mAb (Clone 2C3)

Catalog No.(s): CSB-RA231179A0HU, CSB-RA231179A0HU-50, CSB-RA231179A0HU-100

Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The...

CusaBio

Anti AURKB mAb (Clone 4E5)

Catalog No.(s): CSB-RA230110A0HU, CSB-RA230110A0HU-50, CSB-RA230110A0HU-100

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation...

CusaBio

Anti LRG1 mAb (Clone 7A1)

Catalog No.(s): CSB-RA229992A0HU, CSB-RA229992A0HU-50, CSB-RA229992A0HU-100

extracellular exosome, extracellular region, extracellular space, ficolin-1-rich granule lumen, intracellular membrane-bounded organelle, membrane, specific granule lumen, tertiary granule lumen, neutrophil degranulation Product...

CusaBio

Anti STAT3 mAb (Clone 3A9)

Catalog No.(s): CSB-RA229700A0HU, CSB-RA229700A0HU-50, CSB-RA229700A0HU-100

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580,...

CusaBio

Anti UQCRC2 mAb (Clone 2F6)

Catalog No.(s): CSB-RA229127A0HU, CSB-RA229127A0HU-50, CSB-RA229127A0HU-100

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex. Product...

CusaBio

Anti JAK1 mAb (Clone 7A5)

Catalog No.(s): CSB-RA227790A0HU, CSB-RA227790A0HU-50, CSB-RA227790A0HU-100

Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529). Product Specifications Application IHC,...

CusaBio

Anti RNF20 mAb (Clone 2H12)

Catalog No.(s): CSB-RA227095A0HU, CSB-RA227095A0HU-50, CSB-RA227095A0HU-100

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3...

CusaBio

Anti ITGA4 mAb (Clone 1H4)

Catalog No.(s): CSB-RA225859A0HU, CSB-RA225859A0HU-50, CSB-RA225859A0HU-100

Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1...

CusaBio

Anti IGFBP2 mAb (Clone 7G11)

Catalog No.(s): CSB-RA225697A0HU, CSB-RA225697A0HU-50, CSB-RA225697A0HU-100

Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs...