CUSABIO

CusaBio

Anti Phospho-RAF1 (S259) mAb (Clone 4C9)

Catalog No.(s): CSB-RA019284A259phHU, CSB-RA019284A259phHU-50, CSB-RA019284A259phHU-100

Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation,...

CusaBio

Anti Phospho-PXN (Y118) mAb (Clone 1F11)

Catalog No.(s): CSB-RA019112A118phHU, CSB-RA019112A118phHU-50, CSB-RA019112A118phHU-100

Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Product Specifications Application WB, ELISA Reactivity Human Clonality Monoclonal (Clone No.:...

CusaBio

Anti PXN mAb (Clone 2G8)

Catalog No.(s): CSB-RA019112A0HU, CSB-RA019112A0HU-50, CSB-RA019112A0HU-100

Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Product Specifications Application ELISA Reactivity Human Clonality Monoclonal (Clone No.:...

CusaBio

Anti CD45 mAb (Clone 3B10)

Catalog No.(s): CSB-RA019049A0HU, CSB-RA019049A0HU-50, CSB-RA019049A0HU-100

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to...

CusaBio

Anti Phospho-PTPN11 (Y542) mAb (Clone 2E2)

Catalog No.(s): CSB-RA019025A542phHU, CSB-RA019025A542phHU-50, CSB-RA019025A542phHU-100

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1,...

CusaBio

Anti Phospho-PTK2 (Y397) mAb (Clone 1B3)

Catalog No.(s): CSB-RA018994A397phHU, CSB-RA018994A397phHU-50, CSB-RA018994A397phHU-100

Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell...

CusaBio

Anti PTGS2 mAb (Clone 4A9)

Catalog No.(s): CSB-RA018986A0HU, CSB-RA018986A0HU-50, CSB-RA018986A0HU-100

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis (PubMed:26859324, PubMed:27226593). Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in...

CusaBio

Anti Phospho-PTEN (S380) mAb (Clone 4D10)

Catalog No.(s): CSB-RA018964A380phHU, CSB-RA018964A380phHU-50, CSB-RA018964A380phHU-100

Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from...

CusaBio

Anti Phospho-PRKDC (S2056) mAb (Clone 4A4)

Catalog No.(s): CSB-RA018714A2056phHU, CSB-RA018714A2056phHU-50, CSB-RA018714A2056phHU-100

Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic...

CusaBio

Anti Phospho-PRKCZ (T560) mAb (Clone 1B10)

Catalog No.(s): CSB-RA018710A560phHU, CSB-RA018710A560phHU-50, CSB-RA018710A560phHU-100

Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell...

CusaBio

Anti Phospho-PRKCA (T638) mAb (Clone 3A5)

Catalog No.(s): CSB-RA018699A638phHU, CSB-RA018699A638phHU-50, CSB-RA018699A638phHU-100

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac...

CusaBio

Anti PRKAR1A mAb (Clone 1C3)

Catalog No.(s): CSB-RA018694A0HU, CSB-RA018694A0HU-50, CSB-RA018694A0HU-100

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Product Specifications Application WB, IF, ELISA Reactivity Human Clonality Monoclonal (Clone No.: 1C3)

CusaBio

Anti Phospho-PPP2CA (Y307) mAb (Clone 3F11)

Catalog No.(s): CSB-RA018559A307phHU, CSB-RA018559A307phHU-50, CSB-RA018559A307phHU-100

PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from...

CusaBio

Anti Phospho-POLR2A (S5) mAb (Clone 2H4)

Catalog No.(s): CSB-RA018327A05phHU, CSB-RA018327A05phHU-50, CSB-RA018327A05phHU-100

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs...

CusaBio

Anti Phospho-POLR2A (S2) mAb (Clone 2G1)

Catalog No.(s): CSB-RA018327A02phHU, CSB-RA018327A02phHU-50, CSB-RA018327A02phHU-100

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs...

CusaBio

Anti CD31 mAb (Clone 7B7)

Catalog No.(s): CSB-RA017767A0HU, CSB-RA017767A0HU-50, CSB-RA017767A0HU-100

Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient...

CusaBio

Anti PDPN mAb (Clone 4E6)

Catalog No.(s): CSB-RA017739A0HU, CSB-RA017739A0HU-50, CSB-RA017739A0HU-100

Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation...

CusaBio

Anti Phospho-PDGFRB (Y740) mAb (Clone 3B8)

Catalog No.(s): CSB-RA017713A740phHU, CSB-RA017713A740phHU-50, CSB-RA017713A740phHU-100

Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival,...

CusaBio

Anti Phospho-PAK4/PAK5/PAK6 (S474/S560/S602) mAb (Clone 2D1)

Catalog No.(s): CSB-RA017408A474phHU, CSB-RA017408A474phHU-50, CSB-RA017408A474phHU-100

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or...

CusaBio

Anti Phospho-PAK1/PAK2/PAK3 (S144+S141+S139) mAb (Clone 3H12)

Catalog No.(s): CSB-RA017407A144phHU, CSB-RA017407A144phHU-50, CSB-RA017407A144phHU-100

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and...

CusaBio

Anti NPPA mAb (Clone 2E3)

Catalog No.(s): CSB-RA016020A0HU, CSB-RA016020A0HU-50, CSB-RA016020A0HU-100

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and...

CusaBio

Anti Phospho-NFKBIA (S32) mAb (Clone 2D6)

Catalog No.(s): CSB-RA015761A32phHU, CSB-RA015761A32phHU-50, CSB-RA015761A32phHU-100

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting...

CusaBio

Anti NFKBIA mAb (Clone 1E9)

Catalog No.(s): CSB-RA015761A0HU, CSB-RA015761A0HU-50, CSB-RA015761A0HU-100

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting...

CusaBio

Anti Phospho-NBN (S343) mAb (Clone 1B4)

Catalog No.(s): CSB-RA015486A343phHU, CSB-RA015486A343phHU-50, CSB-RA015486A343phHU-100

Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of...

CusaBio

Anti Phospho-MYC (S62) mAb (Clone 2A10)

Catalog No.(s): CSB-RA015270A62phHU, CSB-RA015270A62phHU-50, CSB-RA015270A62phHU-100

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent...

CusaBio

Anti Phospho-MYC (T58+S62) mAb (Clone 4E9)

Catalog No.(s): CSB-RA015270A58-62phHU, CSB-RA015270A58-62phHU-50, CSB-RA015270A58-62phHU-100

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent...

CusaBio

Anti Phospho-MYB (S11) mAb (Clone 3F4)

Catalog No.(s): CSB-RA015261A11phHU, CSB-RA015261A11phHU-50, CSB-RA015261A11phHU-100

Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. Product...

CusaBio

Anti CD20 mAb (Clone 2C6)

Catalog No.(s): CSB-RA015007A0HU, CSB-RA015007A0HU-50, CSB-RA015007A0HU-100

This protein may be involved in the regulation of B-cell activation and proliferation. Product Specifications Application ELISA Reactivity Human Clonality Monoclonal (Clone No.: 2C6)

CusaBio

Anti MMP9 mAb (Clone 29C11)

Catalog No.(s): CSB-RA014679A0HU, CSB-RA014679A0HU-50, CSB-RA014679A0HU-100

Please click here to view other Bone-related ProductsMay play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves...

CusaBio

Anti CD146 mAb (Clone 8A10)

Catalog No.(s): CSB-RA013563A0HU, CSB-RA013563A0HU-50, CSB-RA013563A0HU-100

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous...

CusaBio

Anti Phospho-MAPT (S396) mAb (Clone 1G3)

Catalog No.(s): CSB-RA013481A396phHU, CSB-RA013481A396phHU-50, CSB-RA013481A396phHU-100

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau...

CusaBio

Anti Phospho-MAPT (S324) mAb (Clone 4E8)

Catalog No.(s): CSB-RA013481A324phHU, CSB-RA013481A324phHU-50, CSB-RA013481A324phHU-100

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau...

CusaBio

Anti Phospho-MAPT (T231) mAb (Clone 1G9)

Catalog No.(s): CSB-RA013481A231phHU, CSB-RA013481A231phHU-50, CSB-RA013481A231phHU-100

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau...

CusaBio

Anti Phospho-MAPK8/MAPK9/MAPK10 (T183/T183/T221) mAb (Clone 1A9)

Catalog No.(s): CSB-RA013466A183phHU, CSB-RA013466A183phHU-50, CSB-RA013466A183phHU-100

Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the...

CusaBio

Anti Phospho-MAPK3 (T202/Y204) + MAPK1 (T185/Y187) mAb (Clone 4F6)

Catalog No.(s): CSB-RA013456A204phHU, CSB-RA013456A204phHU-50, CSB-RA013456A204phHU-100

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade...