CUSABIO

CusaBio

Anti Phospho-MTOR (S2448) mAb (Clone 1G6)

Catalog No.(s): CSB-RA008968A2448phHU, CSB-RA008968A2448phHU-50, CSB-RA008968A2448phHU-100

Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least...

CusaBio

Anti FOXO4 mAb (Clone 1A3)

Catalog No.(s): CSB-RA008839A0HU, CSB-RA008839A0HU-50, CSB-RA008839A0HU-100

Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional...

CusaBio

Anti Phospho-FOXO3 (S253) mAb (Clone 1E1)

Catalog No.(s): CSB-RA008836A253phHU, CSB-RA008836A253phHU-50, CSB-RA008836A253phHU-100

Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of...

CusaBio

Anti FOXO3 mAb (Clone 1E2)

Catalog No.(s): CSB-RA008836A0HU, CSB-RA008836A0HU-50, CSB-RA008836A0HU-100

Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (PubMed:21329882)...

CusaBio

Anti FOS mAb (Clone 14C10)

Catalog No.(s): CSB-RA008790A0HU, CSB-RA008790A0HU-50, CSB-RA008790A0HU-100

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms...

CusaBio

Anti FEN1 mAb (Clone 4D9)

Catalog No.(s): CSB-RA008585A0HU, CSB-RA008585A0HU-50, CSB-RA008585A0HU-100

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA...

CusaBio

Anti FABP4 mAb (Clone 1H4)

Catalog No.(s): CSB-RA007945A0HU, CSB-RA007945A0HU-50, CSB-RA007945A0HU-100

Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Product...

CusaBio

Anti Phospho-ESR1 (S118) mAb (Clone 4H1)

Catalog No.(s): CSB-RA007830A118phHU, CSB-RA007830A118phHU-50, CSB-RA007830A118phHU-100

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves...

CusaBio

Anti Phospho-ERN1 (S724) mAb (Clone 1F12)

Catalog No.(s): CSB-RA007795A724phHU, CSB-RA007795A724phHU-50, CSB-RA007795A724phHU-100

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation (PubMed:9637683, PubMed:11175748, PubMed:12637535). The active endoribonuclease domain splices XBP1 mRNA to generate a new...

CusaBio

Anti Phospho-EIF4E (S209) mAb (Clone 1F3)

Catalog No.(s): CSB-RA007556A209phHU, CSB-RA007556A209phHU-50, CSB-RA007556A209phHU-100

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1...

CusaBio

Anti Phospho-EIF2S1 (S51) mAb (Clone 1C6)

Catalog No.(s): CSB-RA007523A51phHU, CSB-RA007523A51phHU-50, CSB-RA007523A51phHU-100

Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal...

CusaBio

Anti Phospho-EIF2AK2 (T446) mAb (Clone 2F8)

Catalog No.(s): CSB-RA007511A446phHU, CSB-RA007511A446phHU-50, CSB-RA007511A446phHU-100

IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts...

CusaBio

Anti Phospho-EGFR (Y1092) mAb (Clone 3H9)

Catalog No.(s): CSB-RA007479A1092phHU, CSB-RA007479A1092phHU-50, CSB-RA007479A1092phHU-100

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN,...

CusaBio

Anti Phospho-EGFR (Y1068) mAb (Clone 1B8)

Catalog No.(s): CSB-RA007479A1068phHU, CSB-RA007479A1068phHU-50, CSB-RA007479A1068phHU-100

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN,...

CusaBio

Anti CYP19A1 mAb (Clone 1H1)

Catalog No.(s): CSB-RA006394A0HU, CSB-RA006394A0HU-50, CSB-RA006394A0HU-100

Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Product Specifications Application WB, IHC, IF, ELISA Reactivity Human Clonality Monoclonal (Clone No.: 1H1)

CusaBio

Anti Phospho-CTNNB1 (S33/S37) mAb (Clone 4C11)

Catalog No.(s): CSB-RA006169A33phHU, CSB-RA006169A33phHU-50, CSB-RA006169A33phHU-100

Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and...

CusaBio

Anti Phospho-CREB1 (S133) mAb (Clone 3C11)

Catalog No.(s): CSB-RA005947A133phHU, CSB-RA005947A133phHU-50, CSB-RA005947A133phHU-100

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which...

CusaBio

Anti CD21 mAb (Clone 16F10)

Catalog No.(s): CSB-RA005934A0HU, CSB-RA005934A0HU-50, CSB-RA005934A0HU-100

Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. Product Specifications Application WB, IHC, IF, FC, ELISA Reactivity Human Clonality Monoclonal...

CusaBio

Anti CNN1 mAb (Clone 2H1)

Catalog No.(s): CSB-RA005655A0HU, CSB-RA005655A0HU-50, CSB-RA005655A0HU-100

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin...

CusaBio

Anti CLDN4 mAb (Clone 2G12)

Catalog No.(s): CSB-RA005506A0HU, CSB-RA005506A0HU-50, CSB-RA005506A0HU-100

Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight...

CusaBio

Anti CLDN18 Monoclonal mAb (Clone 25E3)

Catalog No.(s): CSB-RA005498A2HU, CSB-RA005498A2HU-50, CSB-RA005498A2HU-100

Product Specifications Application FC, ELISA Reactivity Human Clonality Monoclonal (Clone No.: 25000)

CusaBio

Anti Claudin-18.2 Monoclonal (Zolbetuximab-like) mAb (Clone 9C2)

Catalog No.(s): CSB-RA005498A1HU, CSB-RA005498A1HU-50, CSB-RA005498A1HU-100

Product Specifications Application FC, ELISA Reactivity Human Clonality Monoclonal (Clone No.: 9C2)

CusaBio

Anti CETP mAb (Clone 2F1)

Catalog No.(s): CSB-RA005267A0HU, CSB-RA005267A0HU-50, CSB-RA005267A0HU-100

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density...

CusaBio

Anti CDKN1B mAb (Clone 1G2)

Catalog No.(s): CSB-RA005087A0HU, CSB-RA005087A0HU-50, CSB-RA005087A0HU-100

Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2...

CusaBio

Anti Phospho-CDK2 (Y15) mAb (Clone 2C4)

Catalog No.(s): CSB-RA005061A15phHU, CSB-RA005061A15phHU-50, CSB-RA005061A15phHU-100

Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA...

CusaBio

Anti CDC45 mAb (Clone 4B4)

Catalog No.(s): CSB-RA005020A0HU, CSB-RA005020A0HU-50, CSB-RA005020A0HU-100

Required for initiation of chromosomal DNA replication. Product Specifications Application ELISA Reactivity Human Clonality Monoclonal (Clone No.: 4B4)

CusaBio

Anti CDC25C mAb (Clone 3E6)

Catalog No.(s): CSB-RA004996A0HU, CSB-RA004996A0HU-50, CSB-RA004996A0HU-100

Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates...

CusaBio

Anti CDC25B mAb (Clone 3D6)

Catalog No.(s): CSB-RA004995A0HU, CSB-RA004995A0HU-50, CSB-RA004995A0HU-100

Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and...

CusaBio

Anti CD99 mAb (Clone 9A5)

Catalog No.(s): CSB-RA004973A0HU, CSB-RA004973A0HU-50, CSB-RA004973A0HU-100

Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but...

CusaBio

Anti CD97 mAb (Clone 3A7)

Catalog No.(s): CSB-RA004972A0HU, CSB-RA004972A0HU-50, CSB-RA004972A0HU-100

Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity). Product Specifications Application IHC, IF,...

CusaBio

Anti CD9 mAb (Clone 3A2)

Catalog No.(s): CSB-RA004969A0HU, CSB-RA004969A0HU-50, CSB-RA004969A0HU-100

Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion. Product Specifications Application WB, IHC, IF, FC,...

CusaBio

Anti CD86 mAb (Clone 1G8)

Catalog No.(s): CSB-RA004965A0HU, CSB-RA004965A0HU-50, CSB-RA004965A0HU-100

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as...

CusaBio

Anti CD81 mAb (Clone 9F7)

Catalog No.(s): CSB-RA004960A0HU, CSB-RA004960A0HU-50, CSB-RA004960A0HU-100

May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV. Product Specifications Application WB,...

CusaBio

Anti CD74 mAb (Clone 8H11)

Catalog No.(s): CSB-RA004956A0HU, CSB-RA004956A0HU-50, CSB-RA004956A0HU-100

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal...

CusaBio

Anti CD63 mAb (Clone 2E5)

Catalog No.(s): CSB-RA004950A0HU, CSB-RA004950A0HU-50, CSB-RA004950A0HU-100

Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell...