MHC Tetramers are used for the detection of antigen-specific T-cell populations. MHC-peptide tetramer complexes recognize antigen specific T-cells at the single cell level, allowing for accurate measurements of the functional immune response in cancer, infectious diseases, and autoimmune diseases. Due to their increased avidity, MHC tetramers stably bind to cognate TcRs and are evaluated using flow cytometry.
| Product Specifications | |
| Application | FC |
| Reactivity | Mouse |
| Conjugation | PE |
| Peptide Sequence | MEVGWYRSPFSRVVHLYRNGK |
| Citations for T-Select I-Ab MOG35-55 Tetramer-PE – 2 Found |
| Ryu, Jae Kyu; Petersen, Mark A; Murray, Sara G; Baeten, Kim M; Meyer-Franke, Anke; Chan, Justin P; Vagena, Eirini; Bedard, Catherine; Machado, Michael R; Rios Coronado, Pamela E; Prod'homme, Thomas; Charo, Israel F; Lassmann, Hans; Degen, Jay L; Zamvil, Scott S; Akassoglou, Katerina. Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Nature Communications. 2015;6:8164. PubMed |
| Sonner, Jana K; Keil, Melanie; Falk-Paulsen, Maren; Mishra, Neha; Rehman, Ateequr; Kramer, Magdalena; Deumelandt, Katrin; Röwe, Julian; Sanghvi, Khwab; Wolf, Lara; von Landenberg, Anna; Wolff, Hendrik; Bharti, Richa; Oezen, Iris; Lanz, Tobias V; Wanke, Florian; Tang, Yilang; Brandao, Ines; Mohapatra, Soumya R; Epping, Lisa; Grill, Alexandra; Röth, Ralph; Niesler, Beate; Meuth, Sven G; Opitz, Christiane A; Okun, Jürgen G; Reinhardt, Christoph; Kurschus, Florian C; Wick, Wolfgang; Bode, Helge B; Rosenstiel, Philip; Platten, Michael. Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology. Nature Communications. 2019;10(1):4877. PubMed |
