In cells in which apoptosis occurs, the chromatin DNA is cut by endonuclease at linker DNA site between nucleosomes. Then, DNA fragments, which are a number of multimers of nucleosomal units exit in nuclei. In TUNEL method, 3’-OH DNA ends generated by DNA fragmentation is nick end labeled with fluorescein-dUTP, mediated by terminal deoxynucleotidyl transferase (TdT). This method allows specific staining.
| Citations for MEBSTAIN Apoptosis TUNEL Kit Direct – 20 Found |
| Katuri, V; Tang, Y; Li, C; Jogunoori, W; Deng, C-X; Rashid, A; Sidawy, A N; Evans, S; Reddy, E P; Mishra, B; Mishra, L. Critical interactions between TGF-beta signaling/ELF, and E-cadherin/beta-catenin mediated tumor suppression. Oncogene. 2006;25(13):1871-86. PubMed |
| Yano, Takashi; Ito, Kosei; Fukamachi, Hiroshi; Chi, Xin-Zi; Wee, Hee-Jun; Inoue, Ken-ichi; Ida, Hiroshi; Bouillet, Philippe; Strasser, Andreas; Bae, Suk-Chul; Ito, Yoshiaki. The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. Molecular And Cellular Biology. 2006;26(12):4474-88. PubMed |
| Hojo, Takuo; Al-Zi'abi, Mohamad Omar; Komiyama, Junichi; Manabe, Noboru; Acosta, Tomas J; Okuda, Kiyoshi. Expression and localization of cFLIP, an anti-apoptotic factor, in the bovine corpus luteum. The Journal Of Reproduction And Development. 2010;56(2):230-5. PubMed |
| Krelin, Yakov; Berkovich, Liron; Amit, Moran; Gil, Ziv. Association between tumorigenic potential and the fate of cancer cells in a syngeneic melanoma model. Plos One. 8(4):e62124. PubMed |
| Yotsumoto, Fusanori; Fukagawa, Satoshi; Miyata, Kohei; Nam, Sung Ouk; Katsuda, Takahiro; Miyahara, Daisuke; Odawara, Takashi; Manabe, Sadao; Ishikawa, Toyokazu; Yasunaga, Shin'ichiro; Miyamoto, Shingo. HB-EGF Is a Promising Therapeutic Target for Lung Cancer with Secondary Mutation of EGFR(T790M). Anticancer Research. 2017;37(7):3825-3831. PubMed |
| Lian, Chengjie; Gao, Bo; Wu, Zizhao; Qiu, Xianjian; Peng, Yan; Liang, Anjing; Xu, Caixia; Su, Peiqiang; Huang, Dongsheng. Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells. Molecular Medicine Reports. 2017;16(4):4730-4736. PubMed |
| Asano, Mamiko; Tanaka, Satoshi; Sakaguchi, Minoru; Matsumura, Hitoshi; Yamaguchi, Takako; Fujita, Yoshikazu; Tabuse, Katsuyoshi. Normothermic Microwave Irradiation Induces Death of HL-60 Cells through Heat-Independent Apoptosis. Scientific Reports. 2017;7(1):11406. PubMed |
| Nakamura, Hideki; Takahashi, Yoshiko; Yamamoto-Fukuda, Tomomi; Horai, Yoshiro; Nakashima, Yoshikazu; Arima, Kazuhiko; Nakamura, Tatsufumi; Koji, Takehiko; Kawakami, Atsushi. Direct infection of primary salivary gland epithelial cells by human T lymphotropic virus type I in patients with Sjögren's syndrome. Arthritis & Rheumatology (Hoboken, N.j.). 2015;67(4):1096-106. PubMed |
| Miyazaki, Makoto; Otomo, Ryo; Matsushima-Hibiya, Yuko; Suzuki, Hidenobu; Nakajima, Ayana; Abe, Naomi; Tomiyama, Arata; Ichimura, Koichi; Matsuda, Koichi; Watanabe, Toshiki; Ochiya, Takahiro; Nakagama, Hitoshi; Sakai, Ryuichi; Enari, Masato. The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas. Cell Death Discovery. 4:56. PubMed |
| Gao, Bo; Gao, Wenjie; Wu, Zizhao; Zhou, Taifeng; Qiu, Xianjian; Wang, Xudong; Lian, Chengjie; Peng, Yan; Liang, Anjing; Qiu, Jincheng; Zhu, Yuanxin; Xu, Caixia; Li, Yibing; Su, Peiqiang; Huang, Dongsheng. Melatonin rescued interleukin 1β-impaired chondrogenesis of human mesenchymal stem cells. Stem Cell Research & Therapy. 2018;9(1):162. PubMed |
| Kozako, Tomohiro; Mellini, Paolo; Ohsugi, Takeo; Aikawa, Akiyoshi; Uchida, Yu-Ichiro; Honda, Shin-Ichiro; Suzuki, Takayoshi. Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines. Bmc Cancer. 2018;18(1):791. PubMed |
| Tsuruta, Yuya; Shibutani, Shusaku; Watanabe, Rie; Iwata, Hiroyuki. Apoptosis induced by Ibaraki virus does not affect virus replication and cell death in hamster lung HmLu-1 cells. The Journal Of Veterinary Medical Science. 2019;81(2):197-203. PubMed |
| Kozako, Tomohiro; Aikawa, Akiyoshi; Ohsugi, Takeo; Uchida, Yu-Ichiro; Kato, Naho; Sato, Keisuke; Ishitsuka, Kenji; Yoshimitsu, Makoto; Honda, Shin-Ichiro. High expression of NAMPT in adult T-cell leukemia/lymphoma and anti-tumor activity of a NAMPT inhibitor. European Journal Of Pharmacology. 2019;865:172738. PubMed - Comments: Used in: ICC |
| Takemoto, Kazumasa; Tani, Naoki; Takada-Horisawa, Yuki; Fujimura, Sayoko; Tanno, Nobuhiro; Yamane, Mariko; Okamura, Kaho; Sugimoto, Michihiko; Araki, Kimi; Ishiguro, Kei-Ichiro. Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination. Cell Reports. 2020;31(8):107686. PubMed - Comments: Used in: IF |
| Yamada, Naoya; Karasawa, Tadayoshi; Kimura, Hiroaki; Watanabe, Sachiko; Komada, Takanori; Kamata, Ryo; Sampilvanjil, Ariunaa; Ito, Junya; Nakagawa, Kiyotaka; Kuwata, Hiroshi; Hara, Shuntaro; Mizuta, Koichi; Sakuma, Yasunaru; Sata, Naohiro; Takahashi, Masafumi. Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure. Cell Death & Disease. 2020;11(2):144. PubMed - Comments: Used in: IHC |
| Takemoto, Kazumasa; Tani, Naoki; Takada-Horisawa, Yuki; Fujimura, Sayoko; Tanno, Nobuhiro; Yamane, Mariko; Okamura, Kaho; Sugimoto, Michihiko; Araki, Kimi; Ishiguro, Kei-Ichiro. Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination. Cell Reports. 2020;31(8):107686. PubMed - Comments: Used in: ICC |
| Tanno, Nobuhiro; Kuninaka, Shinji; Fujimura, Sayoko; Takemoto, Kazumasa; Okamura, Kaho; Takeda, Naoki; Araki, Kimi; Araki, Masatake; Saya, Hideyuki; Ishiguro, Kei-Ichiro. Phosphorylation of the Anaphase Promoting Complex activator FZR1/CDH1 is required for Meiosis II entry in mouse male germ cell. Scientific Reports. 2020;10(1):10094. PubMed - Comments: Used in: IF |
| Storniolo, Carolina E; Cabral, Marisol; Busquets, Maria A; Martín-Venegas, Raquel; Moreno, Juan J. Dual Behavior of Long-Chain Fatty Acids and Their Cyclooxygenase/Lipoxygenase Metabolites on Human Intestinal Caco-2 Cell Growth. Frontiers In Pharmacology. 11:529976. PubMed |
| Shimizu, Yoshimi; Isoda, Katsuhiro; Taira, Yuichiro; Taira, Ikuko; Kondoh, Masuo; Ishida, Isao. Anti-tumor effect of a recombinant Bifidobacterium strain secreting a claudin-targeting molecule in a mouse breast cancer model. European Journal Of Pharmacology. 2020;887:173596. PubMed - Comments: Used in: IHC |
| Jin, Congyun; Yonezawa, Atsushi; Yoshimatsu, Hiroki; Imai, Satoshi; Koyanagi, Madoka; Yamanishi, Kaori; Nakagawa, Shunsaku; Itohara, Kotaro; Omura, Tomohiro; Nakagawa, Takayuki; Nagai, Junya; Matsubara, Kazuo. Effect of riboflavin deficiency on development of the cerebral cortex in Slc52a3 knockout mice. Scientific Reports. 2020;10(1):18443. PubMed - Comments: Used in: IHC |