The α3 mutation significantly reduces the binding of MHC tetramer to human CD8. To minimizes the aberrant effect of some CD8 antibodies; clone SFCI21Thy2D3 (also known as “T8”) is recommended.
| Product Specifications | |
| Application | FC |
| Reactivity | Human |
| Conjugation | APC |
| Peptide Sequence | ELAGIGILTV |
| Citations for iTAg Tetramer/APC - HLA-A*02:01 Mart-1 (ELAGIGILTV) – 3 Found |
| Akiyama, Yasuto; Tanosaki, Ryuji; Inoue, Naoki; Shimada, Makiko; Hotate, Yukie; Yamamoto, Akifumi; Yamazaki, Naoya; Kawashima, Ichiro; Nukaya, Ikuei; Takesako, Kazutoh; Maruyama, Kouji; Takaue, Yoichi; Yamaguchi, Ken. Clinical response in Japanese metastatic melanoma patients treated with peptide cocktail-pulsed dendritic cells. Journal Of Translational Medicine. 2005;3(1):4. PubMed |
| Takahara, Masashi; Miyai, Manami; Tomiyama, Mai; Mutou, Masato; Nicol, Andrew J; Nieda, Mie. Copulsing tumor antigen-pulsed dendritic cells with zoledronate efficiently enhance the expansion of tumor antigen-specific CD8+ T cells via Vgamma9gammadelta T cell activation. Journal Of Leukocyte Biology. 2008;83(3):742-54. PubMed |
| Tomiyama, Mai; Takahara, Masashi; Egawa, Kohji; Nieda, Mie. Mature dendritic cells are superior to immature dendritic cells in expanding antigen-specific naive and memory CD8+ T cells. Anticancer Research. 2004;24(5C):3327-33. PubMed |