The α3 mutation significantly reduces the binding of MHC tetramer to human CD8. To minimizes the aberrant effect of some CD8 antibodies; clone SFCI21Thy2D3 (also known as “T8”) is recommended.
| Product Specifications | |
| Application | FC |
| Reactivity | Human |
| Conjugation | APC |
| Peptide Sequence | GLCTLVAML |
| Citations for iTAg Tetramer/APC - HLA-A*02:01 EBV (GLCTLVAML) – 2 Found |
| Shultz, Leonard D; Saito, Yoriko; Najima, Yuho; Tanaka, Satoshi; Ochi, Toshiki; Tomizawa, Mariko; Doi, Takehiko; Sone, Akiko; Suzuki, Nahoko; Fujiwara, Hiroshi; Yasukawa, Masaki; Ishikawa, Fumihiko. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2010;107(29):13022-7. PubMed |
| Tomiyama, Mai; Takahara, Masashi; Egawa, Kohji; Nieda, Mie. Mature dendritic cells are superior to immature dendritic cells in expanding antigen-specific naive and memory CD8+ T cells. Anticancer Research. 2004;24(5C):3327-33. PubMed |