Anti TMEM119 pAb (ATL-HPA051870 w/enhanced validation)

Atlas

Catalog No: ATL-HPA051870-25

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Application: IHC 
Clonality: Polyclonal 
Host: Rabbit 
Reactivity: Human 
Protein Description: transmembrane protein 119
Gene Name: TMEM119
Alternative Gene Name:
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000054675: 52%, ENSRNOG00000000700: 46%
Entrez Gene ID: 338773
Uniprot ID: Q4V9L6
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Citations for Anti TMEM119 pAb (ATL-HPA051870 w/enhanced validation) – 26 Found

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Immunity. 2017 Sep 19;47(3):566-581.e9. doi: 10.1016/j.immuni.2017.08.008. 

Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts.
Brain Pathol. 2018 Nov;28(6):791-805. doi: 10.1111/bpa.12583. Epub 2017 Dec 28. 

TMEM119 silencing inhibits cell viability and causes the apoptosis of gastric cancer SGC-7901 cells.
Oncol Lett. 2018 Jun;15(6):8281-8286. doi: 10.3892/ol.2018.8358. Epub 2018 Mar 28. 

TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation.
J Clin Invest. 2018 Dec 3;128(12):5399-5412. doi: 10.1172/JCI121901. Epub 2018 Oct 29. 

Microglia damage precedes major myelin breakdown in X-linked adrenoleukodystrophy and metachromatic leukodystrophy.
Glia. 2019 Jun;67(6):1196-1209. doi: 10.1002/glia.23598. Epub 2019 Feb 11. 

Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry.
Elife. 2019 Aug 1;8:e48051. doi: 10.7554/eLife.48051. 

Distinct microglial and macrophage distribution patterns in the concentric and lamellar lesions in Baló's disease and neuromyelitis optica spectrum disorders.
Brain Pathol. 2020 Nov;30(6):1144-1157. doi: 10.1111/bpa.12898. Epub 2020 Sep 23. 

Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages.
Acta Neuropathol Commun. 2022 May 9;10(1):72. doi: 10.1186/s40478-022-01370-3. 

Advances in Visualizing Microglial Cells in Human Central Nervous System Tissue.
Biomolecules. 2022 Apr 19;12(5):603. doi: 10.3390/biom12050603. 

Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis.
Brain. 2017 Jul 1;140(7):1900-1913. doi: 10.1093/brain/awx113. 

Pro-inflammatory activation of microglia in the brain of patients with sepsis.
Neuropathol Appl Neurobiol. 2019 Apr;45(3):278-290. doi: 10.1111/nan.12502. Epub 2018 Jun 19. 

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.
Immunity. 2019 Jan 15;50(1):253-271.e6. doi: 10.1016/j.immuni.2018.11.004. Epub 2018 Nov 21. 

A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis.
Brain. 2019 Nov 1;142(11):3440-3455. doi: 10.1093/brain/awz287. 

Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment.
Acta Neuropathol Commun. 2019 Dec 11;7(1):206. doi: 10.1186/s40478-019-0850-z. 

Microglia express TMEM119 in the brains of Nasu-Hakola disease.
Intractable Rare Dis Res. 2019 Nov;8(4):260-265. doi: 10.5582/irdr.2019.01123. 

Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation.
Brain Pathol. 2020 Sep;30(5):897-912. doi: 10.1111/bpa.12865. Epub 2020 Jun 26. 

Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment.
EMBO J. 2020 Aug 3;39(15):e103790. doi: 10.15252/embj.2019103790. Epub 2020 Jun 22. 

A loss of mature microglial markers without immune activation in schizophrenia.
Glia. 2021 May;69(5):1251-1267. doi: 10.1002/glia.23962. Epub 2021 Jan 7. 

Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration.
Acta Neuropathol. 2021 Jun;141(6):881-899. doi: 10.1007/s00401-021-02293-4. Epub 2021 Mar 29. 

Activated microglia do not increase 18 kDa translocator protein (TSPO) expression in the multiple sclerosis brain.
Glia. 2021 Oct;69(10):2447-2458. doi: 10.1002/glia.24052. Epub 2021 Jun 19. 

Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy.
Acta Neuropathol. 2022 Aug;144(2):211-239. doi: 10.1007/s00401-022-02440-5. Epub 2022 Jun 17. 

Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency.
Mol Cell. 2021 Apr 1;81(7):1515-1533.e5. doi: 10.1016/j.molcel.2021.01.019. Epub 2021 Feb 10. 

MicroRNA-34a activation in tuberous sclerosis complex during early brain development may lead to impaired corticogenesis.
Neuropathol Appl Neurobiol. 2021 Oct;47(6):796-811. doi: 10.1111/nan.12717. Epub 2021 Jun 14. 

VISTA regulates microglia homeostasis and myelin phagocytosis, and is associated with MS lesion pathology.
Acta Neuropathol Commun. 2021 May 18;9(1):91. doi: 10.1186/s40478-021-01186-7. 

Molecular Signature of Neuroinflammation Induced in Cytokine-Stimulated Human Cortical Spheroids.
Biomedicines. 2022 Apr 29;10(5):1025. doi: 10.3390/biomedicines10051025. 

B-cells Drive Response to PD-1 Blockade in Glioblastoma Upon Neutralization of TGFβ-mediated Immunosuppression.
Res Sq [Preprint]. 2023 Jan 9:rs.3.rs-2399170. doi: 10.21203/rs.3.rs-2399170/v1.