Neurofibrillary tangles that are one of main pathological characteristics in the Alzheimer's disease (AD) brain are paired helical filaments (PHF) accumulated in the cell body of the neuron. The component of this PHF is known to be an excessively phosphorylated tau. Tau is one of proteins that stabilize microtubules and is necessary to form microtubules. However when it is excessively phosphorylated, it is thought that it disturbs microtubule formation, which causes neuronal cell death. There is a Ca2+/Calmodulin-dependent protein kinase II (CaM kinase II) as an enzyme that phosphorylates tau. It was especially found that its Ser 416 is strongly phosphorylated. Usually CaM kinase II abundantly exists in the synapses of the neurons, whereas it was reported that a large amount of Cam kinases II is accumulated in the cell bodies in the AD brain. This antibody was produced using a human tau peptide that is phosphorylated at Ser 416 as an antigen. It is expected to be useful to research about participation of tau and CaM kinase II in the development of AD.
| Product Specifications |
| Application |
IHC |
| Reactivity |
Rat, Human |
| Clonality |
Polyclonal |
| Host |
Rabbit |
