Application: ICC, IHC
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human
Protein Description: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Gene Name: SMARCA2
Alternative Gene Name: BAF190, BRM, hBRM, hSNF2a, SNF2, SNF2L2, SNF2LA, Sth1p, SWI2
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000024921: 82%, ENSRNOG00000011931: 81%
Entrez Gene ID: 6595
Uniprot ID: P51531
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human
Protein Description: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Gene Name: SMARCA2
Alternative Gene Name: BAF190, BRM, hBRM, hSNF2a, SNF2, SNF2L2, SNF2LA, Sth1p, SWI2
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000024921: 82%, ENSRNOG00000011931: 81%
Entrez Gene ID: 6595
Uniprot ID: P51531
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
| Cognate Antibody/Antigen for Anti SMARCA2 pAb (ATL-HPA029981) | |
| Antigen | PrEST Antigen SMARCA2 (ATL-APrEST86802) |
| Documents & Links for Anti SMARCA2 pAb (ATL-HPA029981) | |
| Datasheet | Anti SMARCA2 pAb (ATL-HPA029981) Datasheet (External Link) |
| Vendor Page | Anti SMARCA2 pAb (ATL-HPA029981) at Atlas |
| Documents & Links for Anti SMARCA2 pAb (ATL-HPA029981) | |
| Datasheet | Anti SMARCA2 pAb (ATL-HPA029981) Datasheet (External Link) |
| Vendor Page | Anti SMARCA2 pAb (ATL-HPA029981) |
| Citations for Anti SMARCA2 pAb (ATL-HPA029981) – 12 Found |
| Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma. Oncotarget. 2017 Jun 6;8(23):37423-37434. doi: 10.18632/oncotarget.16965. PubMed |
| Successful treatment with nivolumab for SMARCA4-deficient non-small cell lung carcinoma with a high tumor mutation burden: A case report. Thorac Cancer. 2019 May;10(5):1285-1288. doi: 10.1111/1759-7714.13070. Epub 2019 Apr 10. PubMed |
| SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines. Sci Rep. 2019 Aug 12;9(1):11661. doi: 10.1038/s41598-019-48152-x. PubMed |
| Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome. Nat Genet. 2012 Feb 26;44(4):445-9, S1. doi: 10.1038/ng.1105. PubMed |
| Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type. J Pathol. 2016 Feb;238(3):389-400. doi: 10.1002/path.4633. Epub 2015 Dec 21. PubMed |
| Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type. Mod Pathol. 2016 Jan;29(1):60-6. doi: 10.1038/modpathol.2015.129. Epub 2015 Nov 13. PubMed |
| Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma. PLoS One. 2016 Oct 20;11(10):e0164554. doi: 10.1371/journal.pone.0164554. eCollection 2016. PubMed |
| The clinicopathological significance of SWI/SNF alterations in gastric cancer is associated with the molecular subtypes. PLoS One. 2021 Jan 22;16(1):e0245356. doi: 10.1371/journal.pone.0245356. eCollection 2021. PubMed |
| Perspectives and Issues in the Assessment of SMARCA4 Deficiency in the Management of Lung Cancer Patients. Cells. 2021 Jul 29;10(8):1920. doi: 10.3390/cells10081920. PubMed |
| A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun. 2022 Oct 10;13(1):5969. doi: 10.1038/s41467-022-33430-6. PubMed |
| Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers. Nat Commun. 2022 Nov 10;13(1):6814. doi: 10.1038/s41467-022-34562-5. PubMed |
| SMARCA4 biology in alveolar rhabdomyosarcoma. Oncogene. 2022 Mar;41(11):1647-1656. doi: 10.1038/s41388-022-02205-0. Epub 2022 Jan 29. PubMed |