Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).
| Product Specifications | |
| Application | WB, ELISA |
| Reactivity | Human |
| Clonality | Monoclonal (Clone No.: 7A1) |
| Documents & Links for Anti PTPN11 mAb (Clone 7A1) | |
| Datasheet | Anti PTPN11 mAb (Clone 7A1) Datasheet |
| Vendor Page | Anti PTPN11 mAb (Clone 7A1) at CUSABIO |
| Documents & Links for Anti PTPN11 mAb (Clone 7A1) | |
| Datasheet | Anti PTPN11 mAb (Clone 7A1) Datasheet |
| Vendor Page | Anti PTPN11 mAb (Clone 7A1) |