Anti PREX1 pAb (ATL-HPA001927)

Atlas Antibodies

SKU: ATL-HPA001927-25

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Product Description

Protein Description: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Gene Name: PREX1
Alternative Gene Name: KIAA1415, P-REX1
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000039621: 78%, ENSRNOG00000006952: 78%
Entrez Gene ID: 57580
Uniprot ID: Q8TCU6
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Product Specifications

• Application: ICC, IHC
• Reactivity: Human
• Clonality: Polyclonal
• Host: Rabbit
• Immunogen: CAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEP
• Gene Sequence: CAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREEALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEP
• Gene ID - Mouse: ENSMUSG00000039621
• Gene ID - Rat: ENSRNOG00000006952
• Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.

Documents & Links

Citations

Citations for Anti PREX1 pAb (ATL-HPA001927) – 10 Found

Chávez-Vargas, Lydia; Adame-García, Sendi Rafael; Cervantes-Villagrana, Rodolfo Daniel; Castillo-Kauil, Alejandro; Bruystens, Jessica G H; Fukuhara, Shigetomo; Taylor, Susan S; Mochizuki, Naoki; Reyes-Cruz, Guadalupe; Vázquez-Prado, José. Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING. The Journal Of Biological Chemistry. 2016;291(12):6182-99. 

Marei, Hadir; Carpy, Alejandro; Woroniuk, Anna; Vennin, Claire; White, Gavin; Timpson, Paul; Macek, Boris; Malliri, Angeliki. Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration. Nature Communications. 2016;7( 26887924):10664. 

Rosmaninho, Pedro; Mükusch, Susanne; Piscopo, Valerio; Teixeira, Vera; Raposo, Alexandre Asf; Warta, Rolf; Bennewitz, Romina; Tang, Yeman; Herold-Mende, Christel; Stifani, Stefano; Momma, Stefan; Castro, Diogo S. Zeb1 potentiates genome-wide gene transcription with Lef1 to promote glioblastoma cell invasion. The Embo Journal. 2018;37(15) 

Cervantes-Villagrana, Rodolfo Daniel; Color-Aparicio, Víctor Manuel; Reyes-Cruz, Guadalupe; Vázquez-Prado, José. Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs. Journal Of Cell Communication And Signaling. 2019;13(2):179-191. 

Lindsay, Colin R; Lawn, Samuel; Campbell, Andrew D; Faller, William J; Rambow, Florian; Mort, Richard L; Timpson, Paul; Li, Ang; Cammareri, Patrizia; Ridgway, Rachel A; Morton, Jennifer P; Doyle, Brendan; Hegarty, Shauna; Rafferty, Mairin; Murphy, Ian G; McDermott, Enda W; Sheahan, Kieran; Pedone, Katherine; Finn, Alexander J; Groben, Pamela A; Thomas, Nancy E; Hao, Honglin; Carson, Craig; Norman, Jim C; Machesky, Laura M; Gallagher, William M; Jackson, Ian J; Van Kempen, Leon; Beermann, Friedrich; Der, Channing; Larue, Lionel; Welch, Heidi C; Ozanne, Brad W; Sansom, Owen J. P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nature Communications. 2011;2( 22109529):555. 

Campbell, Andrew D; Lawn, Samuel; McGarry, Lynn C; Welch, Heidi C; Ozanne, Bradford W; Norman, Jim C. P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments. Plos One. 8(1):e53982. 

Stadler, Charlotte; Rexhepaj, Elton; Singan, Vasanth R; Murphy, Robert F; Pepperkok, Rainer; Uhlén, Mathias; Simpson, Jeremy C; Lundberg, Emma. Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. Nature Methods. 2013;10(4):315-23. 

Marotti, Jonathan D; Muller, Kristen E; Tafe, Laura J; Demidenko, Eugene; Miller, Todd W. P-Rex1 Expression in Invasive Breast Cancer in relation to Receptor Status and Distant Metastatic Site. International Journal Of Breast Cancer. 2017( 28698809):4537532. 

Cervantes-Villagrana, Rodolfo Daniel; Adame-García, Sendi Rafael; García-Jiménez, Irving; Color-Aparicio, Víctor Manuel; Beltrán-Navarro, Yarely Mabell; König, Gabriele M; Kostenis, Evi; Reyes-Cruz, Guadalupe; Gutkind, J Silvio; Vázquez-Prado, José. Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gα(q) and Gα(13) proteins. The Journal Of Biological Chemistry. 2019;294(2):531-546. 

Adame-García, Sendi Rafael; Cervantes-Villagrana, Rodolfo Daniel; Orduña-Castillo, Lennis Beatriz; Del Rio, Jason C; Gutkind, J Silvio; Reyes-Cruz, Guadalupe; Taylor, Susan S; Vázquez-Prado, José. cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits. The Journal Of Biological Chemistry. 2019;294(7):2232-2246.