Application: ICC, IHC
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human
Protein Description: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Gene Name: PREX1
Alternative Gene Name: KIAA1415, P-REX1
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000039621: 78%, ENSRNOG00000006952: 78%
Entrez Gene ID: 57580
Uniprot ID: Q8TCU6
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human
Protein Description: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Gene Name: PREX1
Alternative Gene Name: KIAA1415, P-REX1
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000039621: 78%, ENSRNOG00000006952: 78%
Entrez Gene ID: 57580
Uniprot ID: Q8TCU6
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
| Cognate Antibody/Antigen for Anti PREX1 pAb (ATL-HPA001927) | |
| Antigen | PrEST Antigen PREX1 (ATL-APrEST86391) |
| Documents & Links for Anti PREX1 pAb (ATL-HPA001927) | |
| Datasheet | Anti PREX1 pAb (ATL-HPA001927) Datasheet (External Link) |
| Vendor Page | Anti PREX1 pAb (ATL-HPA001927) at Atlas |
| Documents & Links for Anti PREX1 pAb (ATL-HPA001927) | |
| Datasheet | Anti PREX1 pAb (ATL-HPA001927) Datasheet (External Link) |
| Vendor Page | Anti PREX1 pAb (ATL-HPA001927) |
| Citations for Anti PREX1 pAb (ATL-HPA001927) – 10 Found |
| Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING. J Biol Chem. 2016 Mar 18;291(12):6182-99. doi: 10.1074/jbc.M115.712216. Epub 2016 Jan 21. PubMed |
| Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration. Nat Commun. 2016 Feb 18;7:10664. doi: 10.1038/ncomms10664. PubMed |
| Zeb1 potentiates genome-wide gene transcription with Lef1 to promote glioblastoma cell invasion. EMBO J. 2018 Aug 1;37(15):e97115. doi: 10.15252/embj.201797115. Epub 2018 Jun 14. PubMed |
| Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs. J Cell Commun Signal. 2019 Jun;13(2):179-191. doi: 10.1007/s12079-018-00502-6. Epub 2019 Jan 5. PubMed |
| P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nat Commun. 2011 Nov 22;2:555. doi: 10.1038/ncomms1560. PubMed |
| P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments. PLoS One. 2013;8(1):e53982. doi: 10.1371/journal.pone.0053982. Epub 2013 Jan 30. PubMed |
| Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. Nat Methods. 2013 Apr;10(4):315-23. doi: 10.1038/nmeth.2377. Epub 2013 Feb 24. PubMed |
| P-Rex1 Expression in Invasive Breast Cancer in relation to Receptor Status and Distant Metastatic Site. Int J Breast Cancer. 2017;2017:4537532. doi: 10.1155/2017/4537532. Epub 2017 Jun 15. PubMed |
| Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gα(q) and Gα(13) proteins. J Biol Chem. 2019 Jan 11;294(2):531-546. doi: 10.1074/jbc.RA118.006254. Epub 2018 Nov 16. PubMed |
| cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits. J Biol Chem. 2019 Feb 15;294(7):2232-2246. doi: 10.1074/jbc.RA118.006691. Epub 2018 Dec 10. PubMed |