Anti Neurocan (NCAN) Peptides pAb

Cosmo Bio LTD

Catalog No: CAC-NU-07-005

• 
• 

Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.

Click here to browse a well organized list of products for Bone, Collagen, and Extracellular Matrix research.

Neurocan is a nervous tissue-unique, secretory proteoglycan that carries predominantly chondroitin sulfate side chains. Its expression gradually decreases with the nervous tissue development. In the immature brain, neurocan exists inafull-length form with a 240 kDa-core glycoprotein, whereas it exists totally in proteolytic fragments of the NH2-terminal half (neurocan-N) with a 130 kDa-core glycopeptide and the COOH-terminal half (neurocan-C) with a 150 kDa-core glycopeptide. Neurocan is implicated in the neural network formation, and is a susceptibility factor for bipolar disorder. This proteoglycan is upregulated in the lesion site of the central nervous system, and is a major component of the glial scar. In addition, neurocan-N, not neurocan-C, is detectable in the perineuronal nets of some neurons. This antibody recognizes effectively neurocan-N as well as the full-length neurocan.

References:
1) Oohira, A., Matsui, F., Tokita, Y., Yamauchi, S., & Aono, S., Molecular interactions of neural chondroitin sulfate proteoglycans in the brain development, (2000) Arch.Biochem.Biophys., 374, 24-34.
2) Fumiko Matsui, Masako Nishizuka, Yoko Yasuda, Sachiko Aono, Eiji Watanabe, Atsuhiko Oohira. Occurrence of a N-terminal proteolytic fragment of neurocan, not a C-terminal half, in a perineuronal net in the adult rat cerebrum, (1998) Brain Res., 790, 45-51
3) Matsui, F., Watanabe, E., & Oohira, A., Immunological identification of two proteglycan fragments derived from neurocan, a brain-specific chondroitin sulfate proteoglycan, (1994) Neurochem. Int., 25, 425-431.