Anti N(Omega)-(Carboxymethyl) Arginine (CMA) mAb (Clone 3F5)

Cosmo Bio LTD

Catalog No: CAC-AGE-M04

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Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.

Background
Advanced Glycation End Product (AGE) is a general term for structures generated in the late stage of non-enzymatic glycation reactions (Millard reactions) between reducing sugars and proteins. AGE accumulation is known to be significantly elevated in age-related diseases such as diabetes and arteriosclerosis.

Nω-(carboxymethyl) arginine (CMA), a CML analogue, is an acid-labile AGE structure which was discovered in enzymatic hydrolysate of glycated collagen. CMA is preferentially generated in glycated collagen.

Source: Professor Nagai Ryuji, Tokai University Faculty of Agriculture Department of Biosciences Food Bioregulation Research Laboratory

Application

Western blotting, 1/100 to 1/200
Immunohistochemistry (frozen sections), 1/50 to 1/100
ELISA, 1/100 to 1/200

References

1) Iijima K, Murata M, Takahara H, Irie S, Fujimoto D. Identification of N(omega)-carboxymethylarginine as a novel acid-labileadvanced glycation end product in collagen. Biochem J. 347 Pt 1:23-27 (2000) PMID: 10727397

2) Mera K., Fujiwara Y., Otagiri M., Sakata N., Nagai R. Immunological Detection of Nε -carboxymethylarginine by Specific Antibody. Ann N Y Acad Sci. 1126, 155-157 (2008) PMID: 18079475