Application: WB, ICC, IHC
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human
Protein Description: mitochondrial pyruvate carrier 1
Gene Name: MPC1
Alternative Gene Name: BRP44L, CGI-129, dJ68L15.3
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000023861: 100%, ENSRNOG00000012415: 100%
Entrez Gene ID: 51660
Uniprot ID: Q9Y5U8
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human
Protein Description: mitochondrial pyruvate carrier 1
Gene Name: MPC1
Alternative Gene Name: BRP44L, CGI-129, dJ68L15.3
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000023861: 100%, ENSRNOG00000012415: 100%
Entrez Gene ID: 51660
Uniprot ID: Q9Y5U8
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
| Cognate Antibody/Antigen for Anti MPC1 pAb (ATL-HPA045119 w/enhanced validation) | |
| Antigen | PrEST Antigen MPC1 (ATL-APrEST84884) |
| Documents & Links for Anti MPC1 pAb (ATL-HPA045119 w/enhanced validation) | |
| Datasheet | Anti MPC1 pAb (ATL-HPA045119 w/enhanced validation) Datasheet (External Link) |
| Vendor Page | Anti MPC1 pAb (ATL-HPA045119 w/enhanced validation) at Atlas |
| Documents & Links for Anti MPC1 pAb (ATL-HPA045119 w/enhanced validation) | |
| Datasheet | Anti MPC1 pAb (ATL-HPA045119 w/enhanced validation) Datasheet (External Link) |
| Vendor Page | Anti MPC1 pAb (ATL-HPA045119 w/enhanced validation) |
| Citations for Anti MPC1 pAb (ATL-HPA045119 w/enhanced validation) – 15 Found |
| Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet. PLoS Genet. 2016 May 13;12(5):e1006056. doi: 10.1371/journal.pgen.1006056. eCollection 2016 May. PubMed |
| MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells. J Biol Chem. 2016 Aug 5;291(32):16448-61. doi: 10.1074/jbc.M116.733840. Epub 2016 Jun 17. PubMed |
| E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10998-1003. doi: 10.1073/pnas.1602754113. Epub 2016 Sep 12. PubMed |
| Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas. Oncotarget. 2017 Jan 3;8(1):1058-1073. doi: 10.18632/oncotarget.13717. PubMed |
| Pioglitazone inhibits mitochondrial pyruvate metabolism and glucose production in hepatocytes. FEBS J. 2017 Feb;284(3):451-465. doi: 10.1111/febs.13992. Epub 2017 Jan 18. PubMed |
| Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin. Nat Commun. 2019 Jan 9;10(1):91. doi: 10.1038/s41467-018-07857-9. PubMed |
| Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content. J Neurosci. 2021 Jan 13;41(2):215-233. doi: 10.1523/JNEUROSCI.1284-20.2020. Epub 2020 Nov 18. PubMed |
| Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria. Elife. 2022 Apr 6;11:e68598. doi: 10.7554/eLife.68598. PubMed |
| Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat Cell Biol. 2017 Sep;19(9):1017-1026. doi: 10.1038/ncb3575. Epub 2017 Aug 14. PubMed |
| Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. Nat Cell Biol. 2017 Sep;19(9):1027-1036. doi: 10.1038/ncb3593. Epub 2017 Aug 14. PubMed |
| Mitochondrial fusion is required for spermatogonial differentiation and meiosis. Elife. 2019 Oct 9;8:e51601. doi: 10.7554/eLife.51601. PubMed |
| Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy. BMC Nephrol. 2020 Jul 14;21(1):274. doi: 10.1186/s12882-020-01931-5. PubMed |
| Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency. Elife. 2022 Feb 21;11:e72595. doi: 10.7554/eLife.72595. PubMed |
| mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity. Nat Commun. 2022 Nov 25;13(1):7252. doi: 10.1038/s41467-022-34763-y. PubMed |
| Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells. Sci Adv. 2023 Mar;9(9):eadd5220. doi: 10.1126/sciadv.add5220. Epub 2023 Mar 1. PubMed |