M6 is a membrane glycoprotein that is abundantly expressed on central neurons in the CHS. Two distinct murine M6 cDNA (designated M6a and M6b) whose deduced amino acid sequences are remarkably similar to that of the major CNS myelin protein PLP/DM20 are known. PLP expression is limited to the white matter. M6a appears in post-mitotic neurons of the brain and spinal cord as early as embryonic day 10, and later in the hippocampus, cerebral cortex, and the granule cells of the cerebellum. In contrast, M6b is expressed at early embryonic stage in the ventricular zone of the spinal cord, and later during development in both neurons and glia.
Monoclonal antibody of 100 μg targeting M6a for FCM, IHC.
| Product Specifications | |
| Application | FC, IHC |
| Reactivity | Mouse |
| Clonality | Monoclonal IgG2a ĸ |
| Host | Rat |
| Immunogen | Mouse M6a-expressing cells |
| Gene ID - Human | |
| Gene ID - Mouse | |
| Formulation | 100 µg IgG in 100 µl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Citations for Anti-M6a (Mouse) mAb (Clone: 321) – 11 Found |
| Cooper, Ben; Werner, Hauke B; Flügge, Gabriele. Glycoprotein M6a is present in glutamatergic axons in adult rat forebrain and cerebellum. Brain Research. 2008;1197:1-12. PubMed - Comments: Used in: IHC |
| Cooper, Ben; Werner, Hauke B; Flügge, Gabriele. Glycoprotein M6a is present in glutamatergic axons in adult rat forebrain and cerebellum. Brain Research. 2008;1197:1-12. PubMed - Comments: Used in: IF |
| Zhao, Jing; Iida, Atsumi; Ouchi, Yasuo; Satoh, Shinya; Watanabe, Sumiko. M6a is expressed in the murine neural retina and regulates neurite extension. Molecular Vision. 2008;14:1623-30. PubMed - Comments: Used in: IHC |
| Dorrell, Craig; Grompe, Maria T; Pan, Fong Cheng; Zhong, Yongping; Canaday, Pamela S; Shultz, Leonard D; Greiner, Dale L; Wright, Chris V; Streeter, Philip R; Grompe, Markus. Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. Molecular And Cellular Endocrinology. 2011;339(1-2):144-50. PubMed - Comments: Used in: IHC |
| Lua, Ingrid; Li, Yuchang; Pappoe, Lamioko S; Asahina, Kinji. Myofibroblastic Conversion and Regeneration of Mesothelial Cells in Peritoneal and Liver Fibrosis. The American Journal Of Pathology. 2015;185(12):3258-73. PubMed - Comments: Used in: IHC |
| Li, Yuchang; Lua, Ingrid; French, Samuel W; Asahina, Kinji. Role of TGF-β signaling in differentiation of mesothelial cells to vitamin A-poor hepatic stellate cells in liver fibrosis. American Journal Of Physiology. Gastrointestinal And Liver Physiology. 2016;310(4):G262-72. PubMed - Comments: Used in: IHC |
| Li, Yuchang; Lua, Ingrid; French, Samuel W; Asahina, Kinji. Role of TGF-β signaling in differentiation of mesothelial cells to vitamin A-poor hepatic stellate cells in liver fibrosis. American Journal Of Physiology. Gastrointestinal And Liver Physiology. 2016;310(4):G262-72. PubMed |
| Lua, Ingrid; Li, Yuchang; Zagory, Jessica A; Wang, Kasper S; French, Samuel W; Sévigny, Jean; Asahina, Kinji. Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers. Journal Of Hepatology. 2016;64(5):1137-1146. PubMed - Comments: Used in: FCM |
| Monteleone, Melisa C; Billi, Silvia C; Brocco, Marcela A; Frasch, Alberto C. Neural glycoprotein M6a is released in extracellular vesicles and modulated by chronic stressors in blood. Scientific Reports. 2017;7(1):9788. PubMed - Comments: Used in: IF |
| Monteleone, Melisa C; Billi, Silvia C; Brocco, Marcela A; Frasch, Alberto C. Neural glycoprotein M6a is released in extracellular vesicles and modulated by chronic stressors in blood. Scientific Reports. 2017;7(1):9788. PubMed |
| Aparicio, Gabriela I; Formoso, Karina; León, Antonella; Frasch, Alberto C; Scorticati, Camila. Identification of Potential Interacting Proteins With the Extracellular Loops of the Neuronal Glycoprotein M6a by TMT/MS. Frontiers In Synaptic Neuroscience. 12:28. PubMed - Comments: Used in: ICC |