Mammalian amino acid transport system is consisted of large variety of transporters, with the reflection of
amino acid molecule variety, and is clessfied into various transport systems by the transportative substrate
selectivity and the Na+
dependence with the reflection of amino acid molecule variety.
L-type amino acid transporter 1 (LAT1) is a predicted 12 membrane-spanning protein and is unique because it
requires an additional single membrane spanning protein, 4F2 heavy chain (4F2hc:CD98), for its functional
expression. L-type is Na+ -independent neutral amino acid transporter agency and essential for the transporter of
large neutral amino acid such as Leucine, Isoleucine, Varine through the plasma membrane. LAT1 is, thus
transporter responsible for the permeation of aromatic or branched-chain amino acids and amino acid-related
drugs such as L-DOPA. LAT has been proposed to be one of the major nutrient transport systems at the
blood-brain barrier. Highly regulated nature and high level of expression in tumor cell lines, LAT is thought to be
up-regulated to support the high protein synthesis for cell glowth and cell activation.
This antibody has been proved to be useful for the immunohistochemistry
| Product Specifications |
| Application |
IHC, WB |
| Reactivity |
Human |
| Clonality |
Monoclonal (Clone No.: 4D9) |
| Host |
Mouse |
