Anti-KDEL mAb (Clone: 1D5)

MBL Life Sciences

SKU: MBL-M181-3

The KDEL (lys-asp-glu-leu)sequence is most common endoplasmic reticulum (ER)retention signal. The ER resident proteins, which should be located in the ER, have this retention motif, and this retention is mediated by KDEL receptor.

Product Specifications

• Application: ICC, IP, WB
• Reactivity: Human, Mouse, Rat, Hamster, Fruit fly
• Clonality: Monoclonal IgG2a ĸ
• Host: Mouse
• Immunogen: Mouse GRP78 C-terminal 644-655 aa
• Formulation: 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Citations for Anti-KDEL mAb (Clone: 1D5) – 13 Found

Hino, Shin-ichiro; Kondo, Shinichi; Yoshinaga, Kazuya; Saito, Atsushi; Murakami, Tomohiko; Kanemoto, Soshi; Sekiya, Hiroshi; Chihara, Kazuyasu; Aikawa, Yuji; Hara, Hideaki; Kudo, Takashi; Sekimoto, Tomohisa; Funamoto, Taro; Chosa, Etsuo; Imaizumi, Kazunori. Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis. Journal Of Bone And Mineral Metabolism. 2010;28(2):131-8. 
- Comments: Used in: IHC

Xiang, Yiwen; Xu, Guilian; Weigel-Van Aken, Kirsten A K. Lactic acid induces aberrant amyloid precursor protein processing by promoting its interaction with endoplasmic reticulum chaperone proteins. Plos One. 2010;5(11):e13820. 
- Comments: Used in: WB

Xiang, Yiwen; Xu, Guilian; Weigel-Van Aken, Kirsten A K. Lactic acid induces aberrant amyloid precursor protein processing by promoting its interaction with endoplasmic reticulum chaperone proteins. Plos One. 2010;5(11):e13820. 
- Comments: Used in: IP

Xiang, Yiwen; Xu, Guilian; Weigel-Van Aken, Kirsten A K. Lactic acid induces aberrant amyloid precursor protein processing by promoting its interaction with endoplasmic reticulum chaperone proteins. Plos One. 2010;5(11):e13820. 
- Comments: Used in: ICC

Furuichi, Tatsuya; Masuya, Hiroshi; Murakami, Tomohiko; Nishida, Keiichiro; Nishimura, Gen; Suzuki, Tomohiro; Imaizumi, Kazunori; Kudo, Takashi; Ohkawa, Kiyoshi; Wakana, Shigeharu; Ikegawa, Shiro. ENU-induced missense mutation in the C-propeptide coding region of Col2a1 creates a mouse model of platyspondylic lethal skeletal dysplasia, Torrance type. Mammalian Genome : Official Journal Of The International Mammalian Genome Society. 2011;22(5-6):318-28. 
- Comments: Used in: IHC

Zhang, Bin; Zheng, Chunlei; Zhu, Min; Tao, Jiayi; Vasievich, Matthew P; Baines, Andrea; Kim, Jinoh; Schekman, Randy; Kaufman, Randal J; Ginsburg, David. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin. Blood. 2011;118(12):3384-91. 
- Comments: Used in: ICC

van de Hoef, Diana L; Bonner, Julia M; Boulianne, Gabrielle L. FKBP14 is an essential gene that regulates Presenilin protein levels and Notch signaling in Drosophila. Development (Cambridge, England). 2013;140(4):810-9. 
- Comments: Used in: ICC

Zhao, Chengzhu; Ichimura, Atsuhiko; Qian, Nianchao; Iida, Tsunaki; Yamazaki, Daiju; Noma, Naruto; Asagiri, Masataka; Yamamoto, Koji; Komazaki, Shinji; Sato, Chikara; Aoyama, Fumiyo; Sawaguchi, Akira; Kakizawa, Sho; Nishi, Miyuki; Takeshima, Hiroshi. Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization. Science Signaling. 2016;9(428):ra49. 
- Comments: Used in: ICC

Nakanishi, Katsuhiro; Morikane, Shota; Hosokawa, Nao; Kajihara, Yuka; Kurohane, Kohta; Niwa, Yasuo; Kobayashi, Hirokazu; Imai, Yasuyuki. Plant-derived secretory component forms secretory IgA with shiga toxin 1-specific dimeric IgA produced by mouse cells and whole plants. Plant Cell Reports. 2019;38(2):161-172. 
- Comments: Used in: ELISA

Matsumoto, Naoto; Miyamoto, Yuki; Hattori, Kohei; Ito, Akihiro; Harada, Hironori; Oizumi, Hiroaki; Ohbuchi, Katsuya; Mizoguchi, Kazushige; Yamauchi, Junji. PP1C and PP2A are p70S6K Phosphatases Whose Inhibition Ameliorates HLD12-Associated Inhibition of Oligodendroglial Cell Morphological Differentiation. Biomedicines. 2020;8(4) 
- Comments: Used in: IF

Yagyu, Kazuya; Hasegawa, Yuto; Sato, Mina; Oh-Hashi, Kentaro; Hirata, Yoko. Activation of protein kinase R in the manganese-induced apoptosis of PC12 cells. Toxicology. 2020;442:152526. 
- Comments: Used in: WB

Yoshimoto, Shohei; Morita, Hiromitsu; Matsuda, Miho; Katakura, Yoshinori; Hirata, Masato; Hashimoto, Shuichi. NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment. Laboratory Investigation; A Journal Of Technical Methods And Pathology. 2021;101(1):38-50. 

Ninagawa, Satoshi; Tada, Seiichiro; Okumura, Masaki; Inoguchi, Kenta; Kinoshita, Misaki; Kanemura, Shingo; Imami, Koshi; Umezawa, Hajime; Ishikawa, Tokiro; Mackin, Robert B; Torii, Seiji; Ishihama, Yasushi; Inaba, Kenji; Anazawa, Takayuki; Nagamine, Takahiko; Mori, Kazutoshi. Antipsychotic olanzapine-induced misfolding of proinsulin in the endoplasmic reticulum accounts for atypical development of diabetes. Elife. 2020;9 
- Comments: Used in: IF