Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
| Product Specifications | |
| Application | IHC, ELISA |
| Reactivity | Human |
| Clonality | Monoclonal (Clone No.: 4G3) |
| Documents & Links for Anti FBP1 mAb (Clone 4G3) | |
| Datasheet | Anti FBP1 mAb (Clone 4G3) Datasheet |
| Vendor Page | Anti FBP1 mAb (Clone 4G3) at CUSABIO |
| Documents & Links for Anti FBP1 mAb (Clone 4G3) | |
| Datasheet | Anti FBP1 mAb (Clone 4G3) Datasheet |
| Vendor Page | Anti FBP1 mAb (Clone 4G3) |