Anti DNA-Directed RNA Polymerase II Subunit RPB1 (POLR2A) CTD Phosopho-Ser2 mAb (Clone 3E7C7)

Cosmo Bio

SKU: CAC-CEC-015

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Background
RNA polymerase II (RNAPII) transcribes all protein-coding genes and many non-coding genes, and the activity of RNAPII correlates with the phosphorylation state of RPB1, the large catalytic subunit of RNAPII.. RPB1 has an unusual C-terminal domain (CTD) that consists of repeats of the heptapeptide consensus sequence N-Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7-C, of which there are 52 copies in mammals. The amino acids in these repeats are potential targets for modification, such as phosphorylation and glycosylation.

Antigen/Source	RNA polymerase 2, CTD Ser2ph
Host	Rat
Immunogen	Human
Reacts with	Human/Mouse/Rat/Monkey/Hamster
Clone	3E7C7
Isotype	IgG2a
Conjugation	Unlabeled
Fraction	Ig fraction - Ion Exchange /Gel Filtration
Applications	Western Blot/Immunocytochemistry (cell)/Chromatin Immunoprecipitation
Preservative	0.05% NaN3 in LIQ
Storage	-70C

References
1) Odawara et al. (2011) BMC Genomics. 12:516. PMID: 22011111.

Product Specifications

• Application: ChIP, ICC, WB, ELISA
• Reactivity: Monkey, Mouse, Rat, Human, Hamster
• Clonality: Monoclonal (Clone No.: 3E7C7)
• Host: Rat