Anti Chondroitin Sulfate A mAb (Clone 2H6)

Cosmo Bio LTD

Catalog No: CAC-NU-07-001

Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.

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Chondroitin sulfate, a polysaccharide moiety of proteoglycans, is one of the major components of the extracellular matrix. It is composed of the repeating unit, [→4GlcA 1→3GalNAc 1→], commonly sulfated at C-4 and/or C-6 of GalNAc. In the central nervous system, the most abundant glycosaminoglycan is chondroitin sulfate rich in [GlcA-GalNAc(4S)], namely chondroitin sulfate A. Chondroitin sulfate polysaccharides are involved in the formation, regeneration, and maintenance of the neural network. This monoclonal antibody effectively recognizes chondroitin sulfate A, especially in glycosaminoglycans occurring in the developing central nervous system.

References:
1) Oohira, A., et al. (1994) Neuroscience. 60:145-157. PMID: 8052408.
2) Yamamoto, Y., et al. (1995) Eur. J. Histochem. 39:265-272. PMID: 8835180.

Citations for Anti Chondroitin Sulfate A mAb (Clone 2H6) – 2 Found

Kamermans, Alwin; Planting, Kirsten E; Jalink, Kees; van Horssen, Jack; de Vries, Helga E. Reactive astrocytes in multiple sclerosis impair neuronal outgrowth through TRPM7-mediated chondroitin sulfate proteoglycan production. Glia. 2019;67(1):68-77. 

Chelini, Gabriele; Mirzapourdelavar, Hadi; Durning, Peter; Baidoe-Ansah, David; Sethi, Manveen K; O'Donovan, Sinead M; Klengel, Torsten; Balasco, Luigi; Berciu, Cristina; Boyer-Boiteau, Anne; McCullumsmith, Robert; Ressler, Kerry J; Zaia, Joseph; Bozzi, Yuri; Dityatev, Alexander; Berretta, Sabina. Focal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory in mice. Cell Reports. 2024;43(5):114112.