Application: WB, FC, ELISA
Clonality: Monoclonal
Purification: Purified - Affinity
Reactivity: Human
Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
Clonality: Monoclonal
Purification: Purified - Affinity
Reactivity: Human
Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
| Documents & Links for Anti BUB1B mAb (Clone 7H4) | |
| Datasheet | Anti BUB1B mAb (Clone 7H4) Datasheet |
| Vendor Page | Anti BUB1B mAb (Clone 7H4) at CUSABIO |
| Documents & Links for Anti BUB1B mAb (Clone 7H4) | |
| Datasheet | Anti BUB1B mAb (Clone 7H4) Datasheet |
| Vendor Page | Anti BUB1B mAb (Clone 7H4) |
