Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.
Component of the Set-2/Ash-2 histone methyltransferase (HMT) complex. Required for di- and trimethylation at Lys-4 of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as a transcriptional regulator. Acts in the germline to limit soma longevity, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids.
References:
Koide et al. The expression of proprotein convertase PACE4 is highly regulated by Hash-2 in placenta: Possible role for placenta-specific basic helix-loop-helix transcription factor, human achaete-scute homologue-2. J. Biochem. 134. 433-440.
| Product Specifications | |
| Application | WB, IHC, IP |
| Reactivity | Human, Mouse |
| Clonality | Polyclonal |
| Host | Rabbit |
| Documents & Links for Anti Achaete-Scute Homolog 2 (ASH-2/MASH-2) pAb (Rabbit, Antiserum) | |
| Datasheet | cac-sk-t01-004_anti-ash-2-pab_datasheet.pdf |
| Documents & Links for Anti Achaete-Scute Homolog 2 (ASH-2/MASH-2) pAb (Rabbit, Antiserum) | |
| Datasheet | cac-sk-t01-004_anti-ash-2-pab_datasheet.pdf |