Mammalian amino acid transport system is consisted of large variety of transporters, with the reflection
of amino acid molecule variety, and is classfied into various transport systems by the transportative
substrate selectivity and the Na+
dependence with the reflection of amino acid molecule variety.
asc-type amino acid transporter 1(Asc-1) is a member of the family of amino acid transporters associated
with type II membrane glycoproteins , which requires an additional single membrane spanning protein, 4F2
heavy chain (4F2hc: CD98), for its functional expression. Asc-1 mediates the transport of neutral amino
acid, in particular, small neutral amino acids such as Gly, L-ala, L-Ser, L-Thr and L-Cys as substrate in
Na+
-independent manner.
This has been proved to be useful for the immunohistochemistry.
