Anti ADAM17 mAb (Clone 5A1)

CUSABIO

Catalog No.:
CSB-RA797631A0HU-50
Immunofluorescence staining of Hela Cells with CSB-RA797631A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
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Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.

Product Specifications
Application IF, ELISA
Reactivity Human
Clonality Monoclonal (Clone No.: 5A1)

Documents & Links for Anti ADAM17 mAb (Clone 5A1)
Datasheet Anti ADAM17 mAb (Clone 5A1) Datasheet

Documents & Links for Anti ADAM17 mAb (Clone 5A1)
Datasheet Anti ADAM17 mAb (Clone 5A1) Datasheet
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