Applications: 5-ALA is applied in variety of scientific fields with wide range. Please refer published papers for details of specific applications.
Application in production of Cytochrome P450 (4)
Improvement of harvest yield or increase of plant greenness (5)
Supplement for culture of microorganism or cells from animals (6)
Research relating production of active oxygen derived from accumulation of excess amount of porphirins (7)(8)
Photodynamic diagnosis for cancer research (9) 5-Aminolevulinic acid (ALA) is a compound which is widely present in the biosphere and plays an important role in the living body as an intermediate of the tetrapyrrole compound biosynthesis pathway for vitamin B12, heme, chlorophyll, etc. ALA is of interest as a biodegradable herbicide(1), an insecticide(2), a growth regulator for plants (3), a precursor of heme proteins(4), and an effective agent used in photodynamic therapy of cancer(5).
(1) Rebeiz, CA et al. Enzyme Microb. Technol. 6, 390-401, 1984.
(2) Rebeiz CA et al. Pesticide Biochem. Physiol. 30, 11-27, 1988.
(3) Hotta, Y. et al. Plant Growth Regulation, 22, 109-114, 1997.
(4) Verderber, E. et al. J. Bacteriol. 14, 4583-4590, 1997.
(5) Grant, WE et al. The Lancet, 342, 147-148, 1993.
Application in production of Cytochrome P450 (4)
Improvement of harvest yield or increase of plant greenness (5)
Supplement for culture of microorganism or cells from animals (6)
Research relating production of active oxygen derived from accumulation of excess amount of porphirins (7)(8)
Photodynamic diagnosis for cancer research (9) 5-Aminolevulinic acid (ALA) is a compound which is widely present in the biosphere and plays an important role in the living body as an intermediate of the tetrapyrrole compound biosynthesis pathway for vitamin B12, heme, chlorophyll, etc. ALA is of interest as a biodegradable herbicide(1), an insecticide(2), a growth regulator for plants (3), a precursor of heme proteins(4), and an effective agent used in photodynamic therapy of cancer(5).
(1) Rebeiz, CA et al. Enzyme Microb. Technol. 6, 390-401, 1984.
(2) Rebeiz CA et al. Pesticide Biochem. Physiol. 30, 11-27, 1988.
(3) Hotta, Y. et al. Plant Growth Regulation, 22, 109-114, 1997.
(4) Verderber, E. et al. J. Bacteriol. 14, 4583-4590, 1997.
(5) Grant, WE et al. The Lancet, 342, 147-148, 1993.
| Documents & Links for 5-Aminolevulinic acid hydrochloride (5-ALA) (Cell Culture Tested) | |
| Datasheet | cri-al-05-1_5-aminolevulinic-acid-hydrochloride-5-ala-cell-culture-tested_datasheet.pdf |
| Vendor Page | 5-Aminolevulinic acid hydrochloride (5-ALA) (Cell Culture Tested) at Cosmo Bio LTD |
| Documents & Links for 5-Aminolevulinic acid hydrochloride (5-ALA) (Cell Culture Tested) | |
| Datasheet | cri-al-05-1_5-aminolevulinic-acid-hydrochloride-5-ala-cell-culture-tested_datasheet.pdf |
| Vendor Page | 5-Aminolevulinic acid hydrochloride (5-ALA) (Cell Culture Tested) |
| Citations for 5-Aminolevulinic acid hydrochloride (5-ALA) (Cell Culture Tested) – 5 Found |
| Minamikawa, Takeo; Matsuo, Hisataka; Kato, Yoshiyuki; Harada, Yoshinori; Otsuji, Eigo; Yanagisawa, Akio; Tanaka, Hideo; Takamatsu, Tetsuro. Simplified and optimized multispectral imaging for 5-ALA-based fluorescence diagnosis of malignant lesions. Scientific Reports. 2016;6( 27149301):25530. PubMed |
| Naya, Yoshio; Oishi, Masakastu; Yamada, Yasunori; Ueda, Takashi; Fujihara, Atsuko; Nakanishi, Hiroyuki; Naito, Yasuyuki; Nakamura, Terukazu; Hongo, Fumiya; Kamoi, Kazumi; Okihara, Koji; Miki, Tsuneharu. Initial experience of combined use of photodynamic diagnosis and narrow band imaging for detection of flat urothelial lesion. International Journal Of Clinical Oncology. 2015;20(3):593-7. PubMed |
| Takahashi, Kenkichi; Ikeda, Naokado; Nonoguchi, Naosuke; Kajimoto, Yoshinaga; Miyatake, Shin-Ichi; Hagiya, Yuichiro; Ogura, Shun-Ichiro; Nakagawa, Hiroshi; Ishikawa, Toshihisa; Kuroiwa, Toshihiko. Enhanced expression of coproporphyrinogen oxidase in malignant brain tumors: CPOX expression and 5-ALA-induced fluorescence. Neuro-Oncology. 2011;13(11):1234-43. PubMed |
| Komoike, Nobuhiko; Kato, Tomohiro; Saijo, Hiroki; Arihiro, Seiji; Hashimoto, Hisashi; Okabe, Masataka; Ito, Masaki; Koido, Shigeo; Homma, Sadamu; Tajiri, Hisao. Photodynamic diagnosis of colitis-associated dysplasia in a mouse model after oral administration of 5-aminolevulinic acid. In Vivo (Athens, Greece). 2013;27(6):747-53. PubMed |
| Hou, Chongxian; Yamaguchi, Shigeru; Ishi, Yukitomo; Terasaka, Shunsuke; Kobayashi, Hiroyuki; Motegi, Hiroaki; Hatanaka, Kanako C; Houkin, Kiyohiro. Identification of PEPT2 as an important candidate molecule in 5-ALA-mediated fluorescence-guided surgery in WHO grade II/III gliomas. Journal Of Neuro-Oncology. 2019;143(2):197-206. PubMed |