Ubiquitin-Proteasome Related Products from Cosmo Bio
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Product Line-up
Multiubiquitin Chain
SUMO and related proteins
Proteasome components and related proteins
Product Flyers
Cosmo Bio Ubiquitin Proteasome Product Flyer
NEW! Anti-Pan Ubiquitin Monobody
Ubiquitin-Proteasome System Related Products from Cosmo Bio Japan
Multiubiquitin Chain
The Ubiquitin-proteasome protein degradation system is the key mechanism for various biological activities. In this system, the protein to be degraded is tagged by the multiubiquitin chain, this process so-called as ubiquitylation. Three enzymes are known to be involved in the ubiquitylation; E1, E2 and E3. E3 ubiquitin ligase confers specificity to ubiquitylation by recognizing the target protein. The ubiquitylated proteins are degraded by the 26S proteasome.
SUMO and related proteins
SUMO is a ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.
Proteasome components and related proteins
The 26S proteasome is a protein complex with a molecular mass of ~2,000 kDa. It is essential not only for eliminating damaged or misfolded proteins but also for degrading short-lived regulatory proteins involved in cell cycle regulation, DNA repair, signal transduction, apoptosis, and metabolic regulation. The 26S proteasome is composed of the 20S core particle (CP) and the 19S regulatory particle (RP). The RP is further subdivided into lid and base sub-complexes.
Anti Ubiquitin Monoclonal Antibodies and
NEW! anti-Pan-Ubiquitin Monobody
| Name | Clone | Reactivity | Applications | Cat. No. |
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Anti-Pan Ubiquitin Monobody |
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| Anti Multiubiquitin Chain mAb (Clone FK2) | FK2 | ELISA, WB | NBT-0918-2 (former NBT-MFK-004) |
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| Anti Multiubiquitin, Chain mAb (Clone FK1) | FK1 | ELISA, WB | NBT-0924 （former NBT-MFK-002) |
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Ligases/conjugating enzymes
| Name | Clone | Reactivity | Applications | Cat. No. |
| Anti Ubiquitin-Conjugating enzyme E2 (UBE2/RAD6) pAb (Rabbit, Affinity Purified) | Mouse, Rat, Human, Hamster | IP, IF, WB, ICC | BAM-70-020-EX | |
| Anti Denticleless Protein Homolog (DTL/CDT2) pAb (Rabbit, Antiserum). An E2 ubiquiting protein ligase homolog. | Mouse, Human, Hamster, Rat | IP, IF, WB, FC, ICC | BAM-70-115-EX | |
| Anti UBR5 pAb (Rabbit, Affinity Purified). Ubiquitin Protein Ligase E3 Component N-Recognin 5 | Mouse | WB | PRX-MKA0896AF | |
| Anti E3 Ubiquitin-Protein Ligase UBR5 (EDD) pAb (Rabbit, Affinity Purified) | Mouse, Human | WB, IF, ICC | BAM-70-501EX | |
| Anti SIAH 2 (E3 ubiquitin protein ligase) pAb | Human | WB | KAL-KR056 | |
| Anti Human E3 Ubiquitin-Protein Ligase RAD18 pAb (Rabbit, Affinity Purified) | Human | IP, IF, WB | BAM-70-023-EX | |
| Anti Mouse E3 Ubiquitin-Protein Ligase RAD18 pAb (Rabbit, Purified Ig) | Mouse | IP, IF, IHC, WB, ICC | BAM-70-025-EX | |
| Anti SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) pAb (Rabbit, Antiserum) | PRX-MKA1625 | |||
| Anti SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) pAb (Rabbit, Purified Ig) | PRX-MKA1625PA | |||
| Anti TRIM28 pAb (E3 Ubiquiting ligase) (Rabbit, Affinity Purified) | Human | WB | PRX-KB7016GNPAF | |
| Anti TRIM28 pAb (E3 Ubiquiting ligase) (Rabbit, Antiserum) | Human | WB | PRX-KB7016GNP |
Ubiquitin-Like Modifiers
| Name | Clone | Reactivity | Applications | Cat. No. |
| Anti DNA Damage-Binding Protein 1 (DDB1) mAb (Clone 43233-3-1). adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex | 43233-3-1 | Human, Hamster, Chicken | IP, IF, WB | CAC-KUP-TM-M05 |
| Anti Ubiquitin-Like Modifier-Activating Enzyme ATG7 mAb (Clone ATG7-2) | ATG7-2 | Human | IP, WB | CAC-CTB-AT7-M01 |
| Anti Autophagy-Related Protein 8i (ATG8i) pAb (Rabbit, Antiserum) | Soybean, Arabidopsis, Plant | IP, WB | CAC-KYU-TY-P01 | |
| Anti DCUN1D4 pAb (Rabbit, Antiserum). Involved in neddylation of all cullins. | Mouse, Human | WB | PRX-MKA0276 | |
| Anti DCUN1D4 pAb (Rabbit, Purified). Involved in neddylation of all cullins. | Mouse | IHC(p) | KAL-KG410 | |
| Anti E3 SUMO-Protein Ligase RanBP2 pAb (Rabbit, Antiserum) | Human, Mouse, Rat | IP, WB, Immuno-staining, ICC | BAM-71-003-EX | |
| Anti Small Ubiquitin-Related Modifier 1 (SUMO1) mAb (Clone 4D12) | 4D12 | Monkey, Human, Mouse, Rat | IF, IHC(f), WB, ELISA | BAM-70-653-EX |
| Anti Small Ubiquitin-Related Modifier 1 (SUMO1) mAb (Clone 4D12, Biotin-conjugated) | 4D12 | Human, Monkey, Mouse, Rat, Hamster, Guinea Pig | IF, IHC(f), WB, ELISA, ICC | BAM-70-654EX |
| Anti Small Ubiquitin-Related Modifier 1 (SUMO1) mAb (Clone 4D12, Fluorescein-conjugated) | 4D12 | Human, Monkey, Mouse, Rat | IF, IHC(f), ICC | BAM-70-655EX |
| Anti Small Ubiquitin-Related Modifier 2 (SUMO2) and Small Ubiquitin-Related Modifier 3 (SUMO3) mAb (Clone 3H12) | 3H12 | Monkey, Mouse, Rat, Human | ICC, IHC, WB, IF | CAC-CEC-044 (former CAC-CE-042A) |
| Anti Small Ubiquitin-Related Modifier 2 and 3 (SUMO2/SUMO3) mAb (Clone 3H12) | 3H12 | Monkey, Mouse, Rat, Human, Hamster | ICC, ELISA, IHC(f), WB, IF | BAM-70-657-EX |
Deubiquitylase
| Name | Clone | Reactivity | Applications | Cat. No. |
| Anti BAP1 (deubiquitylase) pAb (Rabbit, Antiserum) | Mouse | WB | PRX-MKA0272 |
Proteasome
| Name | Clone | Reactivity | Applications | Cat. No. |
| Anti 20S Proteasome mAb (Clone GC3α) | GC3α | Plant, Fish, Yeast, Rat, Human, Frog | IEM, IHC(f), WB, IF, ICC | CAC-SZU-PS-M01 |
| Anti 20S Proteasome Subunit Alpha Type-2 mAb (Clone GC4/5) | GC4/5 | Plant, Fish, Yeast, Rat, Human, Frog | WB, IEM | CAC-SZU-PS-M03 |
| Anti 20S Proteasome Subunit Alpha Type-4 mAb (Clone GC3β) | GC3β | Plant, Fish, Rat, Human, Yeast, Frog | WB | CAC-SZU-PS-M02 |
| Anti 26S Proteasome Regulatory Subunit RPN1 (NAS1) pAb (Rabbit, Antiserum) | S. cerevisiae | WB | BAM-62-200-EX | |
| Anti 26S Proteasome Regulatory Subunit RPN11 (PAD1) pAb (Rabbit, Antiserum) | S. pombe | IP, WB | BAM-63-133-EX | |
| Anti 26S Proteasome Regulatory Subunit RPN12 pAb (Rabbit, Affinity Purified) | S. cerevisiae | IP, WB | BAM-62-209EX | |
| Anti 26S Proteasome Regulatory Subunit RPN3 pAb (Rabbit, Antiserum) | S. cerevisiae | IP, WB | BAM-62-201-EX | |
| Anti 26S Proteasome Regulatory Subunit RPN5 pAb (Rabbit, Affinity Purified) | S. cerevisiae | IP, WB | BAM-62-203-EX | |
| Anti 26S Proteasome Regulatory Subunit RPN7 pAb (Rabbit, Affinity Purified) | S. cerevisiae | IP, WB | BAM-62-205-EX | |
| Anti 26S Proteasome Regulatory Subunit RPN9 pAb (Rabbit, Purified Ig) | S. cerevisiae | IP, WB | BAM-62-207-EX | |
| Anti Probable 26S Proteasome Regulatory Subunit p28 (NAS6) pAb (Rabbit, Affinity Purified) | S. cerevisiae | IP, WB | BAM-62-213-EX | |
| Anti PSMC5 pAb (Rabbit, Antiserum). Proteasome 26S Subunit, ATPase5 | Human | WB | PRX-KB6588GNP |
Others
| Name | Clone | Reactivity | Applications | Cat. No. |
| Anti ASXL1 pAb (Rabbit, Antiserum) | Mouse | WB | PRX-MKA0978 | |
| Anti ASXL1 pAb (Rabbit, Purified Ig) | Mouse | WB | PRX-MKA0978PA | |
| Anti BACH1 pAb (Rabbit, Affinity Purified) | Human | WB | PRX-KB3015GNPAF | |
| Anti BACH1 pAb (Rabbit, Antiserum) | Human | WB | PRX-KB3015GNP | |
| Anti BAP1 pAb (Rabbit, Purified Ig) | Mouse | WB | PRX-MKA0272PA | |
| Anti Bip pAb (Rabbit) | WB | COP-COP-080017 | ||
| Anti CLOCK pAb (Rabbit, Antiserum) | Mouse | WB | PRX-MKA0334 | |
| Anti CLOCK pAb (Rabbit, Purified Ig) | Mouse | WB | PRX-MKA0334PA | |
| Anti Glutamate-Rich WD Repeat-Containing Protein 1 (GRWD1) pAb (Rabbit, Affinity Purified) | Mouse, Rat, Human | IF, WB, IP, ChIP, ICC | BAM-70-130EX | |
| Anti GRWD1 pAb (Rabbit, Antiserum) | Mouse, Human | WB | PRX-MKA1942 | |
| Anti GRWD1 pAb (Rabbit, Purified Ig) | Mouse, Human | WB | PRX-MKA1942PA | |
| Anti HMG20A pAb (Rabbit, Antiserum) | Human | WB | PRX-KB5656GNP | |
| Anti HSC70 pAb (Rabbit) | WB | COP-COP-080016 | ||
| Anti Melanoma-Associated Antigen D1 (MAGED1/Dlxin-1/NRAGE) mAb (Rabbit, Antiserum) | MD1 | Mouse, Rat, Human | IHC(f), WB, ELISA, ICC | BAM-74-112-EX |
| Anti NFRKB pAb (Rabbit, Affinity Purified) | Human | WB | PRX-KD0093GNPAF | |
| Anti Non-Structural Maintenance of Chromosomes Element 3 Homolog (NSMCE3/MAGE-G1) pAb (Rabbit, Antiserum) | Mouse, Rat, Human | IP, WB, Immuno-affinity chromatography, ELISA | BAM-74-114-EX | |
| Anti PML pAb (Rabbit, Affinity Purified) | Human | WB | PRX-KB4394GNPAF | |
| Anti PML pAb (Rabbit, Antiserum) | Human | WB | PRX-KB4394GNP | |
| Anti Proliferating Cell Nuclear Antigen (PCNA) pAb (Rabbit, Purified IgG) | Mouse, Rat, Human, Mammalian, Hamster, Chicken, Xenopus | IP, ELISA, IF, WB, ICC, DB | BAM-70-080-EX | |
| Anti Sis1(Dnaj) pAb (Rabbit) | Yeast & Protozoa | IP, WB | COP-COP-080051 | |
| Anti SMAD1 pAb (Rabbit, Antiserum) | Human | WB | PRX-KB5319GNP | |
| Anti SMAD4 pAb (Rabbit, Antiserum) | Human | WB | PRX-KB5682GNP | |
| Anti TADA3L pAb (Rabbit, Antiserum) | Human | WB | PRX-KB8170GNP | |
| Anti Ydj1(Dnaj) pAb (Rabbit) | Yeast & Protozoa | IP, WB | COP-COP-080050 | |
| Anti YY1 pAb (Rabbit, Affinity Purified) | Human | WB | PRX-KD0182GNPAF | |
| PCNA | BAM-10-151-EX |