Antibodies for neurodegenerative disease research
ITIH4（Inter-alpha Trypsin Inhibitor Heavy Chain H4） Antibody
ITIH4 is secreted into the blood and cleaved by plasma kallikrein into two fragment proteins.
The gene expressing this protein is localized in the liver, and since ITIH4 peptide fragments have been detected in the sera of patients with hepatocellular carcinoma and cirrhosis, the usefulness of this protein as a biomarker in liver diseases has been reported. Furthermore, experiments using mouse models of amyotrophic lateral sclerosis (ALS) have reported that elevated ITIH4 contributes to the progression of the disease, and this association has also attracted attention. On the other hand, ITIH4 is subject to many post-translational modifications such as sugar additions, making it extremely difficult to apply the antibody to cell staining and flow cytometry using peptides and recombinant proteins as antigens.
Two rat polyclonal antibodies suitable for detection of human ITIH4 are available.
| Product name | Catalog Number |
|---|---|
| Anti ITIH4, Human (Brown Norway Rat) | ICA-TG2-RTP1 |
| Anti ITIH4, Human (Sprague Dawley Rat) | ICA-TG2-RTP2 |
GPNMB（Glycoprotein Nonmetastatic Melanoma Protein B）Antibody
GPNMB is a transmembrane glycoprotein that is specifically expressed in melanocytes and has been suggested to be involved in the regulation of cell growth retardation and metastatic ability.
Recently, Professor Hideaki Hara and his group at Gifu Pharmaceutical University have shown that expression of GPNMB in mice with amyotrophic lateral sclerosis (ALS) suppressed the progression of the disease, indicating that dynamic tracking and functional analysis of GPNMB are useful for ALS research.
Three types of rabbit polyclonal antibodies specific for human and crossed to mouse and rat are available for GPNMB, which is attracting attention as a novel marker for ALS.
| Product name | Catalog Number |
|---|---|
| Anti GPNMB, Human (Rabbit) | ICA-TG1-RBP1 |
| Anti GPNMB, Human (Rabbit) | ICA-TG1-RBP2 |
| Anti GPNMB, Human (Rabbit) | ICA-TG1-RBP3 |
WDR45L（WD Repeat-containing Protein 45-like）Antibody
WDR45L, also known as WIPI-3, has a special structure that repeats 40 amino acids (WD40) seven times.
This protein regulates cell cycle transcription and signal transduction, and is believed to be deeply involved in "cell death" represented by apoptosis and autophagy in particular; however, the detailed functions of this protein have not yet been elucidated in many cases. In recent years, it has also attracted attention as a marker for neurodegenerative diseases associated with cell death, and the demand for kinetic analysis by cell staining is rapidly increasing.
Mouse polyclonal antibodies are available for use in staining mouse cells.
| Product name | Catalog Number |
|---|---|
| Anti WDR45L (Mouse Poly) | ICA-TG3-MSP1 |
Parvalbumin Antibody
It can be used for research on neurological diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease.
| Product name | Catalog Number |
|---|---|
| Anti Parvalbumin, Rat (Rabbit) | ACC-PA001 |
S100-alpha Antibody
It can be used to study function in a number of tissues, including cardiac, skeletal, and vascular smooth muscle cells, as well as the central nervous system.
| Product name | Catalog Number |
|---|---|
| Anti S100 alpha, Human (Rabbit) | ACC-PA002 |
Calbindin D-28k Antibody
It can be used for research on neurological diseases such as Alzheimer's disease.
| Product name | Catalog Number |
|---|---|
| Anti Calbindin D-28k, Rat (Rabbit) | ACC-PA003 |
α-B crystallin p19S／α-B crystallin p45S／α-B crystallin p59S Antibodies
Dysbindin-1 Antibody
It can be used for Hermansky-Pudlak syndrome7 (HPS7) and schizophrenia research.
| Product name | Catalog Number |
|---|---|
| Anti Dysbindin-1, Human (Rabbit) | ACC-PA007 |
Citations
- ■Anti Parvalbumin（Cat.# ACC-PA001）
- Inaguma Y, Kurobe N, Shinohara H, Kato K. (1991) Sensitive immunoassay for rat parvalbumin: tissue distribution and developmental changes. Biochim Biophys Acta. 1075: 68-74.
- ■Anti S100-alpha（Cat.# ACC-PA002）
- Kato K, Haimoto H, Ariyoshi Y, Horisawa M, Washida H, Kimura S. (1985) High levels of S-100a0 (alpha alpha) protein in tumor tissues and in sera of patients with renal cell carcinoma. Jpn J Cancer Res. 76:856-62.
- ■Anti Calbindin D-28k（Cat.# ACC-PA003）
- Zhu YY, Takashi M, Miyake K, Kato K. (1991) Sensitive enzyme immunoassay for human 28 kDa calbindin-D. Clin Chim Acta. 1991 201:183-92.
- ■Anti alpha B crystallin p19S/p45S/p59S（Cat.# ACC-PA004/ACC-PA005/ACC-PA006）
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- 1) Ito H, Okamoto K, Nakayama H, Isobe T, Kato K. (1997) Phosphorylation of B-crystallin in response to various types of stress. J Biol Chem. 272, 29934-29941.
- 2) Kato K, Ito H, Kamei K, Inaguma Y, Iwamoto I, Saga S. (1998) Phosphorylation of B-crystallin in mitotic cells and identification of enzymatic activities responsible for phosphorylation. J Biol Chem. 273,28346-28354.
- 3) Ito H, Iida K, Kamei K, Iwamoto I, Inaguma Y, Kato K. (1999) B-crystallin in rat lens is phosphorylated at an early postnatal age. FEBS Lett. 446, 269-272.
- ■Anti Dysbindin-1（Cat.# ACC-PA007）
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- 1) Ito H, Morishita R, Shinoda T, Iwamoto I, Sudo K, Okamoto K, Nagata KI. (2010) Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation. Mol Psychiatry 15:976-986.
- 2) Ito H, Morishita R, Nagata K. (2016) Schizophrenia susceptibility gene product dysbindin-1 regulates the homeostasis of cyclin D1. Biochim Biophys Acta. 1862: 1383-1391.