1-Oleoyl-Palmitoyl-Phosphatidylcholine Antibody
Phospholipids are known as basic substances that form cell membranes, and together with sugar chains (glycosaminoglycans), they play important roles in intracellular signal transduction, cell-to-cell cross-talk, membrane and protein transfer, cell adhesion, and cytoskeletal reorganization. On the other hand, due to the complexity of its structure and lack of research tools, there have been many unknowns regarding its physiological functions and roles.
Prof. Honke's group at Kochi University and his colleagues have discovered a novel mechanism of membrane localization in which 1-oleoyl-2-palmitoyl-phosphatidylcholine (OPPC), a type of phospholipid molecule with a specific site of unsaturated fatty acid oleic acid, is expressed at the tips of neuronal projections and synaptic sites in the mouse brain to regulate the localization of proteins (dopamine transport proteins and G proteins) 1).
This suggests that phospholipid remodeling occurs in cell membranes and that the resulting OPPCs play an important role in neurotransmission, which may be related to conditions such as Parkinson's disease and dementia, as well as new approaches for improving brain function.
Data
Figure1: OPPC localization analysis on cultured nerve cell(rat PC12 cell, clone#15-3C1)
Figure2: OPPC StructureReferences
- 1) H.Kuge, et al. Functional Compartmentalization of the Plasma Membrane of Neurons by a Unique Acyl Chain Composition of Phospholipids. J. Biol. Chem. 289, 26783-26793 (2014).
Product List
1-Oleoyl-Palmitoyl-Phosphatidylcholine Antibody
| Product name | Catalog Number |
|---|---|
| Anti 1-Oleoyl-Palmitoyl-Phosphatidylcholine (OPPC), (Mouse) , 15-3C1 | SK-KC01-M01 |