Macrokiller (Clodronate liposome)
Clodronic acid, a bisphosphonate known to treat osteoporosis, depletes osteoclasts by inhibiting ATP metabolism as an ATP analog in cells. Clodronate also exerts cytotoxic effects on macrophages such as osteoclasts and microglia, but the disadvantage of clodronate as a single agent is that its effect is reduced due to low uptake by macrophages.
The liposome-encapsulated clodronate also improves macrophage phagocytosis efficiency and cell permeability, and thus has a higher cell-killing effect compared to clodronate alone. Macrophages have been reported to be involved in many diseases such as cancer, Alzheimer's, and allergies, and the clodronate-encapsulated liposome, Macrokiller, is a useful tool for studying these diseases.
Components
- Macrokiller V300
- Empty liposomes for control
Data
Figure1: Cytocidal effect of Macrokiller V300 against primary rat microglia.Dose-dependent cytocidal effect of Macrokiller V300 against primary rat microglia.
A cell viability determined by the XTT assay after 48 hours treated with Macrokiller V300.
Figure2: Selective elimination of adipose tissue macrophages from
primary rat visceral adipocyte culture.
Macrokiller V300 selectively decreases relative mRNA levels of macrophage marker genes.
Macrokiller V300
| Product name | Catalog Number |
|---|---|
| Macrokiller V300 | MKV300 |