CAC Antibody Collection

The antibodies on this page are part of Cosmo Bio's exclusive CAC Collection. For many many thousands of other antibodies from many different makers, use our Search the Store function and our Explore Products drop down menu.

Sumoylation pathway

SUMOylation is a reversible post-translational modification which has emerged as a crucial molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune responses, carcinogenesis, cell cycle progression and apoptosis. Four SUMO isoforms have been identified, which are SUMO1, SUMO2/3 and SUMO4. The small ubiquitin-like modifier (SUMO) pathway is conserved in all eukaryotes and plays pivotal roles in the regulation of gene expression, cellular signaling and the maintenance of genomic integrity. The SUMO catalytic cycle includes maturation, activation, conjugation, ligation and de-modification. The dysregulation of the SUMO system is associated with a number of diseases, particularly cancer. SUMOylation is widely involved in carcinogenesis, DNA damage response, cancer cell proliferation, metastasis and apoptosis. SUMO can be used as a potential therapeutic target for cancer. [from: Han ZJ, Feng YH, Gu BH, Li YM and Chen H. (2018) The post-translational modification, SUMOylation, and cancer (Review). International Journal Of Oncology. 52:1081-1094.]

Product name (click for order info)	Cat No (click for datasheet)	Host	Species specificity
Anti Small Ubiquitin-Related Modifier 2 (SUMO2) and Small Ubiquitin-Related Modifier 3 (SUMO3) mAb (Clone 3H12)	CAC-CE-044	RT	HU MS RT MKY

Anti Small Ubiquitin-Related Modifier 2 (SUMO2) and Small Ubiquitin-Related Modifier 3 (SUMO3) mAb (Clone 3H12)

Cat No: CAC-CE-042A

Description: SUMO is a Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.

References:
1) Saitoh et al. (2006). Exp Cell Res. 312:1418-1430. This antibody is used in ref.1.

Host: RT

Species specificity: HU MS RT MKY

Figure 1:
Immunocytochemistry/Immunofluorescence analysis of SUMO2/3 antibody (3H12) on mouse primary culture neurons.

Figure 2:
Immunoblot analysis of SUMO1 antibody (4D12) and SUMO3 antibody (3H12) on HeLa cell extracts.