Cell / Cell culture products
Human primary hepatocyte-like HepG2 cells with CYP3A4 and other drug-metabolizing enzyme activities
Reprogrammed HepG2 cells (R-HepG2) & special medium
This product is a demethylated cell product of HepG2, a liver cancer-derived cell line. It possesses drug-metabolizing enzyme activity, including CYP3A4, which does not show activity in the HepG2 cell line, and has a cell morphology similar to primary human hepatocytes. Please use it for drug metabolism test and cytotoxicity test.
*This product was developed under the technical guidance of Dr. Luc Gailhouste, Department of Molecular and Cellular Therapy, National Cancer Center Research Institute.
Background
The human HepG2 cell line has been used as an alternative liver model for many years in a wide range of research fields such as carcinogenesis research, toxicity evaluation, screening of anticancer drug candidates, signal transduction research, and molecular biology research. has been pointed out.
Product usage
Schematic diagram of reprogrammed HepG2 cells
CYP3A drug metabolizing enzyme activity in reprogrammed HepG2 cells
Gene expression analysis of reprogrammed HepG2 cells
*Relative value with human primary hepatocytes (day 0) as 1
| Catalog Number | Product Name | Size |
| PMC-R-HEPG2C | Reprogrammed HepG2 cells | 1 Vial |
| PMC-R-HEPG2M | Reprogrammed HepG2 Maintenance Medium | 125 ml |