Cell / Cell culture products
Osteoclast (mouse / rat)
Mouse/rat osteoclasts are induced to differentiate from bone marrow cells to osteoclasts in the presence of M-CSF and RANKL. In addition, by culturing on dentine slices or osteoassay plates at the time of seeding, bone resorption cavities can be formed and bone resorption ability can be evaluated.
Pit formation assay diagram
background
Bone tissue is constantly metabolized by bone resorption and bone formation, and undergoes bone remodeling (reconstruction). Osteoclasts are the only cells responsible for this bone resorption, and it is known that when bone resorption is activated and bone formation is relatively reduced, bone mass decreases and osteoporosis occurs.
Composition
| organization | animal | age in weeks | Composition | Dedicated medium | Catalog number |
| bone marrow | mature animal | SD rat | Osteoclast 2 × 10 6 cells 2 | Product number: PMC-OSCMW (for washing) Product number: PMC-OSCMR (for culture) |
PMC-OSC12C frozen cells |
| ICR mouse | Osteoclast 2 × 10 6 cells 1 tube | Product number: PMC-OSCMW (for washing) Product number: PMC-OSCMM (for culture) |
PMC-OSC14C frozen cells |
Frozen Cells : The cells are delivered frozen in dry ice packaging. You can take it out immediately after delivery and start culturing immediately, or you can freeze it at the temperature specified in the instruction manual.
Product Data
Fig. 1 Rat osteoclast
