CUSABIO

CusaBio

Anti PELP1 mAb (Clone 6H4)

Catalog No.(s): CSB-RA999292A0HU, CSB-RA999292A0HU-50, CSB-RA999292A0HU-100

Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by...

CusaBio

Anti TINF2 mAb (Clone 5G11)

Catalog No.(s): CSB-RA997969A0HU, CSB-RA997969A0HU-50, CSB-RA997969A0HU-100

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its...

CusaBio

Anti PDE4D mAb (Clone 4D4)

Catalog No.(s): CSB-RA996952A0HU, CSB-RA996952A0HU-50, CSB-RA996952A0HU-100

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Product Specifications Application WB, ELISA Reactivity Human Clonality Monoclonal (Clone No.: 4D4)

CusaBio

Anti NUP98 mAb (Clone 2H4)

Catalog No.(s): CSB-RA995655A0HU, CSB-RA995655A0HU-50, CSB-RA995655A0HU-100

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Nup98 and Nup96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. Product Specifications Application WB, IHC, IF,...

CusaBio

Anti APP mAb (Clone 6F10)

Catalog No.(s): CSB-RA994273A0HU, CSB-RA994273A0HU-50, CSB-RA994273A0HU-100

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein...

CusaBio

Anti MAPKAPK2 mAb (Clone 4H8)

Catalog No.(s): CSB-RA990134A0HU, CSB-RA990134A0HU-50, CSB-RA990134A0HU-100

Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following...

CusaBio

Anti STAT6 mAb (Clone 2F10)

Catalog No.(s): CSB-RA988543A0HU, CSB-RA988543A0HU-50, CSB-RA988543A0HU-100

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. Product Specifications Application WB, IHC, ELISA Reactivity Human,...

CusaBio

Anti JUNB mAb (Clone 5H4)

Catalog No.(s): CSB-RA988421A0HU, CSB-RA988421A0HU-50, CSB-RA988421A0HU-100

Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'. Product Specifications Application IHC, IF, ELISA Reactivity Human Clonality Monoclonal (Clone...

CusaBio

Anti SDHB mAb (Clone 7D12)

Catalog No.(s): CSB-RA987662A0HU, CSB-RA987662A0HU-50, CSB-RA987662A0HU-100

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Product...

CusaBio

Anti PTBP1 mAb (Clone 8A1)

Catalog No.(s): CSB-RA987652A0HU, CSB-RA987652A0HU-50, CSB-RA987652A0HU-100

Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to...

CusaBio

Anti SAE1 mAb (Clone 9D8)

Catalog No.(s): CSB-RA987582A0HU, CSB-RA987582A0HU-50, CSB-RA987582A0HU-100

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on...

CusaBio

Anti NUP153 mAb (Clone 8D4)

Catalog No.(s): CSB-RA986790A0HU, CSB-RA986790A0HU-50, CSB-RA986790A0HU-100

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs...

CusaBio

Anti SYNCRIP mAb (Clone 9C7)

Catalog No.(s): CSB-RA984434A0HU, CSB-RA984434A0HU-50, CSB-RA984434A0HU-100

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing...

CusaBio

Anti MET mAb (Clone 2D12)

Catalog No.(s): CSB-RA983271A0HU, CSB-RA983271A0HU-50, CSB-RA983271A0HU-100

Please click here to view other Bone-related ProductsReceptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including...

CusaBio

Anti GRB2 mAb (Clone 6E1)

Catalog No.(s): CSB-RA981267A0HU, CSB-RA981267A0HU-50, CSB-RA981267A0HU-100

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Product Specifications Application WB, IHC, ELISA Reactivity Human, Mouse, Rat Clonality Monoclonal (Clone No.:...

CusaBio

Anti GHR mAb (Clone 10C11)

Catalog No.(s): CSB-RA978909A0HU, CSB-RA978909A0HU-50, CSB-RA978909A0HU-100

Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). Product Specifications Application IHC, IF,...

CusaBio

Anti PRKCQ mAb (Clone 1B2)

Catalog No.(s): CSB-RA978159A0HU, CSB-RA978159A0HU-50, CSB-RA978159A0HU-100

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by...

CusaBio

Anti MYBBP1A mAb (Clone 3A1)

Catalog No.(s): CSB-RA978157A0HU, CSB-RA978157A0HU-50, CSB-RA978157A0HU-100

May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the...

CusaBio

Anti CD274 mAb (Clone 10D4)

Catalog No.(s): CSB-RA977797A0HU, CSB-RA977797A0HU-50, CSB-RA977797A0HU-100

Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. Product...

CusaBio

Anti TXN mAb (Clone 3G7)

Catalog No.(s): CSB-RA977675A0HU, CSB-RA977675A0HU-50, CSB-RA977675A0HU-100

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target...

CusaBio

Anti HAVCR1 mAb (Clone 9E1)

Catalog No.(s): CSB-RA974628A0HU, CSB-RA974628A0HU-50, CSB-RA974628A0HU-100

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair. Product Specifications Application WB, ELISA Reactivity Human,...

CusaBio

Anti SOX2 mAb (Clone 2E1)

Catalog No.(s): CSB-RA973770A0HU, CSB-RA973770A0HU-50, CSB-RA973770A0HU-100

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic...

CusaBio

Anti MUC16 mAb (Clone 10F10)

Catalog No.(s): CSB-RA973154A0HU, CSB-RA973154A0HU-50, CSB-RA973154A0HU-100

Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Product Specifications Application IHC, ELISA Reactivity Human Clonality Monoclonal (Clone No.: 10F10)

CusaBio

Anti LGALS3 mAb (Clone 4E1)

Catalog No.(s): CSB-RA970289A0HU, CSB-RA970289A0HU-50, CSB-RA970289A0HU-100

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early...

CusaBio

Anti CCNE1 mAb (Clone 3A5)

Catalog No.(s): CSB-RA968740A0HU, CSB-RA968740A0HU-50, CSB-RA968740A0HU-100

Essential for the control of the cell cycle at the G1/S (start) transition. Product Specifications Application IHC, IF, ELISA Reactivity Human Clonality Monoclonal (Clone No.: 3A5)

CusaBio

Anti FGFR3 mAb (Clone 6D4)

Catalog No.(s): CSB-RA966627A0HU, CSB-RA966627A0HU-50, CSB-RA966627A0HU-100

Please click here to view other Bone-related ProductsTyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an...

CusaBio

Anti MGMT mAb (Clone 10G7)

Catalog No.(s): CSB-RA966553A0HU, CSB-RA966553A0HU-50, CSB-RA966553A0HU-100

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a...

CusaBio

Anti CDK4 mAb (Clone 8F2)

Catalog No.(s): CSB-RA965615A0HU, CSB-RA965615A0HU-50, CSB-RA965615A0HU-100

Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of...

CusaBio

Anti CSNK2A1 mAb (Clone 2B6)

Catalog No.(s): CSB-RA964915A0HU, CSB-RA964915A0HU-50, CSB-RA964915A0HU-100

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes,...

CusaBio

Anti CDC37 mAb (Clone 10C3)

Catalog No.(s): CSB-RA964136A0HU, CSB-RA964136A0HU-50, CSB-RA964136A0HU-100

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). Product...

CusaBio

Anti ILK mAb (Clone 6A5)

Catalog No.(s): CSB-RA963626A0HU, CSB-RA963626A0HU-50, CSB-RA963626A0HU-100

Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered...

CusaBio

Anti IFIH1 mAb (Clone 3D12)

Catalog No.(s): CSB-RA963423A0HU, CSB-RA963423A0HU-50, CSB-RA963423A0HU-100

Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory...

CusaBio

Anti PLAU mAb (Clone 10E5)

Catalog No.(s): CSB-RA963043A0HU, CSB-RA963043A0HU-50, CSB-RA963043A0HU-100

Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. Product Specifications Application IHC, ELISA Reactivity Human Clonality Monoclonal (Clone No.: 1000000)

CusaBio

Anti CD22 mAb (Clone 3D8)

Catalog No.(s): CSB-RA962691A0HU, CSB-RA962691A0HU-50, CSB-RA962691A0HU-100

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be...

CusaBio

Anti CDK2 mAb (Clone 6A5)

Catalog No.(s): CSB-RA961467A0HU, CSB-RA961467A0HU-50, CSB-RA961467A0HU-100

Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA...