Cosmo Bio USA distributes MHC tetramer products from MBL (Medical & Biological Laboratories Co., Ltd.), a global pioneer in immunological reagents with over 50 years of innovation. MBL was among the first to commercialize MHC tetramers for research use, offering scientists highly stable complexes for sensitive detection of antigen-specific T cells via flow cytometry. Their tetramers are assembled from biotinylated MHC-peptide monomers and fluorochrome-conjugated streptavidin, ensuring reliable performance across applications. A standout innovation is MBL’s patented A245V mutation in the α3 domain of human and macaque MHC class I molecules, which significantly reduces non-specific CD8 binding while preserving TCR interaction—resulting in enhanced staining specificity.
MBL’s expansive tetramer lineup includes human alleles (e.g., HLA-A02:01, HLA-A24:02) and mouse alleles (e.g., H-2Kb, H-2Db), preloaded with peptides from key infectious agents (CMV, influenza, SARS-CoV-2), tumor-associated antigens (e.g., NY-ESO-1, MAGE family), and model systems (OVA, LCMV). These tetramers are available in a variety of fluorochromes—PE, APC, BV421, and more—for broad compatibility with modern flow cytometry platforms. Custom tetramer services are also available for researchers with specialized peptide or allele requirements. With MBL’s rigorously validated, precision-engineered tetramers, Cosmo Bio USA empowers North American scientists engaged in cancer immunotherapy, vaccine research, infectious disease monitoring, and autoimmune studies with high-performance tools for T cell analysis.