The α3 mutation significantly reduces the binding of MHC tetramer to human CD8. To minimizes the aberrant effect of some CD8 antibodies; clone SFCI21Thy2D3 (also known as “T8”) is recommended.
| Product Specifications | |
| Application | FC |
| Reactivity | Human |
| Conjugation | APC |
| Peptide Sequence | YMDGTMSQV |
| Citations for Tetramer/APC - HLA-A*02:01 Tyrosinase (YMDGTMSQV) – 1 Found |
| Akiyama, Yasuto; Tanosaki, Ryuji; Inoue, Naoki; Shimada, Makiko; Hotate, Yukie; Yamamoto, Akifumi; Yamazaki, Naoya; Kawashima, Ichiro; Nukaya, Ikuei; Takesako, Kazutoh; Maruyama, Kouji; Takaue, Yoichi; Yamaguchi, Ken. Clinical response in Japanese metastatic melanoma patients treated with peptide cocktail-pulsed dendritic cells. Journal Of Translational Medicine. 2005;3(1):4. PubMed |