The α3 mutation significantly reduces the binding of MHC tetramer to human CD8. To minimizes the aberrant effect of some CD8 antibodies; clone SFCI21Thy2D3 (also known as “T8”) is recommended.
| Product Specifications | |
| Application | FC |
| Reactivity | Human |
| Conjugation | PE |
| Peptide Sequence | RMFPNAPYL |
| Citations for iTAg Tetramer/PE - HLA-A*02:01 WT-1 (RMFPNAPYL) – 3 Found |
| Najima, Yuho; Tomizawa-Murasawa, Mariko; Saito, Yoriko; Watanabe, Takashi; Ono, Rintaro; Ochi, Toshiki; Suzuki, Nahoko; Fujiwara, Hiroshi; Ohara, Osamu; Shultz, Leonard D; Yasukawa, Masaki; Ishikawa, Fumihiko. Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice. Blood. 2016;127(6):722-34. PubMed |
| Nishida, Sumiyuki; Ishikawa, Takeshi; Egawa, Shinichi; Koido, Shigeo; Yanagimoto, Hiroaki; Ishii, Jun; Kanno, Yoshihide; Kokura, Satoshi; Yasuda, Hiroaki; Oba, Mari Saito; Sato, Maho; Morimoto, Soyoko; Fujiki, Fumihiro; Eguchi, Hidetoshi; Nagano, Hiroaki; Kumanogoh, Atsushi; Unno, Michiaki; Kon, Masanori; Shimada, Hideaki; Ito, Kei; Homma, Sadamu; Oka, Yoshihiro; Morita, Satoshi; Sugiyama, Haruo. Combination Gemcitabine and WT1 Peptide Vaccination Improves Progression-Free Survival in Advanced Pancreatic Ductal Adenocarcinoma: A Phase II Randomized Study. Cancer Immunology Research. 2018;6(3):320-331. PubMed |
| Campillo-Davo, Diana; Fujiki, Fumihiro; Van den Bergh, Johan M J; De Reu, Hans; Smits, Evelien L J M; Goossens, Herman; Sugiyama, Haruo; Lion, Eva; Berneman, Zwi N; Van Tendeloo, Viggo. Efficient and Non-genotoxic RNA-Based Engineering of Human T Cells Using Tumor-Specific T Cell Receptors With Minimal TCR Mispairing. Frontiers In Immunology. 9:2503. PubMed |