The α3 mutation significantly reduces the binding of MHC tetramer to human CD8. To minimizes the aberrant effect of some CD8 antibodies; clone SFCI21Thy2D3 (also known as “T8”) is recommended.
| Product Specifications | |
| Application | FC |
| Reactivity | Human |
| Conjugation | APC |
| Peptide Sequence | NLVPMVATV |
| Citations for iTAg Tetramer/APC - HLA-A*02:01 CMV pp65 (NLVPMVATV) – 2 Found |
| Sabouri, Amir H; Usuku, Koichiro; Hayashi, Daisuke; Izumo, Shuji; Ohara, Yoshiro; Osame, Mitsuhiro; Saito, Mineki. Impaired function of human T-lymphotropic virus type 1 (HTLV-1)-specific CD8+ T cells in HTLV-1-associated neurologic disease. Blood. 2008;112(6):2411-20. PubMed |
| Watanabe, Kazue; Suzuki, Susumu; Kamei, Michi; Toji, Shingo; Kawase, Takakazu; Takahashi, Toshitada; Kuzushima, Kiyotaka; Akatsuka, Yoshiki. CD137-guided isolation and expansion of antigen-specific CD8 cells for potential use in adoptive immunotherapy. International Journal Of Hematology. 2008;88(3):311-320. PubMed |