Human IL-18 ELISA Kit

MBL

Catalog No: MBL-7620

The Human Il-18 ELISA Kit is based on sandwich ELISA and is capable of measuring human Il-18. This kit has a high sensitivity (12.5 pg/ml) and continues to be gather multiple citations every year. With regard to diseases, high levels of IL-18 are detected in the blood of patients with allergic diseases (bronchial asthma, atopic dermatitis, allergic rhinitis) and those with autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus [SLE], adult Still’s disease, multiple sclerosis, Chrohn’s disease, ulcerative colitis). IL-18 is also found in the urine of patients with acute renal disorder and appears to mediate the progression of type 2 diabetes.

Citations for Human IL-18 ELISA Kit – 35 Found

Okamoto, Masakazu; Kawabe, Tsutomu; Iwasaki, Yasumasa; Hara, Toru; Hashimoto, Naozumi; Imaizumi, Kazuyoshi; Hasegawa, Yoshinori; Shimokata, Kaoru. Evaluation of interferon-gamma, interferon-gamma-inducing cytokines, and interferon-gamma-inducible chemokines in tuberculous pleural effusions. The Journal Of Laboratory And Clinical Medicine. 2005;145(2):88-93. 

Wakiguchi, Hiroyuki; Hasegawa, Shunji; Hirano, Reiji; Kaneyasu, Hidenobu; Wakabayashi-Takahara, Midori; Ohga, Shouichi. Successful control of juvenile dermatomyositis-associated macrophage activation syndrome and interstitial pneumonia: distinct kinetics of interleukin-6 and -18 levels. Pediatric Rheumatology Online Journal. 2015;13:49. 

Chiba, Asako; Tamura, Naoto; Yoshikiyo, Kazunori; Murayama, Goh; Kitagaichi, Mie; Yamaji, Ken; Takasaki, Yoshinari; Miyake, Sachiko. Activation status of mucosal-associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus. Arthritis Research & Therapy. 2017;19(1):58. 

Lou, Jun; Wang, Yongli; Zhang, Zhimin; Qiu, Weiqiang. MiR-20b inhibits mycobacterium tuberculosis induced inflammation in the lung of mice through targeting NLRP3. Experimental Cell Research. 2017;358(2):120-128. 

C Weel, Ingrid; Romão-Veiga, Mariana; Matias, Mariana L; Fioratti, Eduardo G; Peraçoli, Jose C; Borges, Vera T; Araujo, João P Jr; Peraçoli, Maria T. Increased expression of NLRP3 inflammasome in placentas from pregnant women with severe preeclampsia. Journal Of Reproductive Immunology. 2017;123:40-47. 

Gibbs, Susan; Kosten, Ilona; Veldhuizen, Rosalien; Spiekstra, Sander; Corsini, Emanuela; Roggen, Erwin; Rustemeyer, Thomas; Feilzer, Albert J; Kleverlaan, Cees J. Assessment of metal sensitizer potency with the reconstructed human epidermis IL-18 assay. Toxicology. 2018;393:62-72. 

Kadowaki, Tomonori; Ohnishi, Hidenori; Kawamoto, Norio; Hori, Tomohiro; Nishimura, Kenichi; Kobayashi, Chie; Shigemura, Tomonari; Ogata, Shohei; Inoue, Yuzaburo; Kawai, Tomoki; Hiejima, Eitaro; Takagi, Masatoshi; Imai, Kohsuke; Nishikomori, Ryuta; Ito, Shuichi; Heike, Toshio; Ohara, Osamu; Morio, Tomohiro; Fukao, Toshiyuki; Kanegane, Hirokazu. Haploinsufficiency of A20 causes autoinflammatory and autoimmune disorders. The Journal Of Allergy And Clinical Immunology. 2018;141(4):1485-1488.e11. 

Hachiya, Akira; Kobayashi, Norimoto; Matsuzaki, Satoshi; Takeuchi, Yusuke; Akazawa, Yohei; Shigemura, Tomonari; Motoki, Noriko; Masumoto, Junya; Agematsu, Kazunaga. Analysis of biomarker serum levels in IVIG and infliximab refractory Kawasaki disease patients. Clinical Rheumatology. 2018;37(7):1937-1943. 

Penczynski, Katharina J; Herder, Christian; Krupp, Danika; Rienks, Johanna; Egert, Sarah; Wudy, Stefan A; Roden, Michael; Remer, Thomas; Buyken, Anette E. Flavonoid intake from fruit and vegetables during adolescence is prospectively associated with a favourable risk factor profile for type 2 diabetes in early adulthood. European Journal Of Nutrition. 2019;58(3):1159-1172. 

Herder, Christian; Schmitt, Andreas; Budden, Florian; Reimer, André; Kulzer, Bernhard; Roden, Michael; Haak, Thomas; Hermanns, Norbert. Association between pro- and anti-inflammatory cytokines and depressive symptoms in patients with diabetes-potential differences by diabetes type and depression scores. Translational Psychiatry. 2018;7(11):1. 

Strączkowski, Marek; Nikołajuk, Agnieszka; Majewski, Radosław; Filarski, Remigiusz; Stefanowicz, Magdalena; Matulewicz, Natalia; Karczewska-Kupczewska, Monika. The effect of moderate weight loss, with or without (1, 3)(1, 6)-β-glucan addition, on subcutaneous adipose tissue inflammatory gene expression in young subjects with uncomplicated obesity. Endocrine. 2018;61(2):275-284. 

Flisiak-Jackiewicz, Marta; Bobrus-Chociej, Anna; Tarasów, Eugeniusz; Wojtkowska, Małgorzata; Białokoz-Kalinowska, Irena; Lebensztejn, Dariusz Marek. Predictive Role of Interleukin-18 in Liver Steatosis in Obese Children. Canadian Journal Of Gastroenterology & Hepatology. 2018:3870454. 

Pietrzak, Daniel; Pietrzak, Aldona; Grywalska, Ewelina; Kiciński, Paweł; Roliński, Jacek; Donica, Helena; Franciszkiewicz-Pietrzak, Kinga; Borzęcki, Andrzej; Socha, Mateusz; Niedziałek, Jarosław; Krasowska, Dorota. Serum concentrations of interleukin 18 and 25-hydroxyvitamin D3 correlate with depression severity in men with psoriasis. Plos One. 13(8):e0201589. 

Bil, Wieneke; van der Bent, Sebastiaan A S; Spiekstra, Sander W; Nazmi, Kamran; Rustemeyer, Thomas; Gibbs, Susan. Comparison of the skin sensitization potential of 3 red and 2 black tattoo inks using interleukin-18 as a biomarker in a reconstructed human skin model. Contact Dermatitis. 2018;79(6):336-345. 

Furuya, Makiko Yashiro; Asano, Tomoyuki; Sumichika, Yuya; Sato, Shuzo; Kobayashi, Hiroko; Watanabe, Hiroshi; Suzuki, Eiji; Kozuru, Hideko; Yatsuhashi, Hiroshi; Koga, Tomohiro; Ohira, Hiromasa; Sekine, Hideharu; Kawakami, Atsushi; Migita, Kiyoshi. Tofacitinib inhibits granulocyte-macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils. Arthritis Research & Therapy. 2018;20(1):196. 

Colasanti, Tania; Fiorito, Silvana; Alessandri, Cristiano; Serafino, Annalucia; Andreola, Federica; Barbati, Cristiana; Morello, Francesca; Alfè, Michela; Di Blasio, Gabriele; Gargiulo, Valentina; Vomero, Marta; Conti, Fabrizio; Valesini, Guido. Diesel exhaust particles induce autophagy and citrullination in Normal Human Bronchial Epithelial cells. Cell Death & Disease. 2018;9(11):1073. 

Semino, Claudia; Carta, Sonia; Gattorno, Marco; Sitia, Roberto; Rubartelli, Anna. Progressive waves of IL-1β release by primary human monocytes via sequential activation of vesicular and gasdermin D-mediated secretory pathways. Cell Death & Disease. 2018;9(11):1088. 

Colasanti, Tania; Fiorito, Silvana; Alessandri, Cristiano; Serafino, Annalucia; Andreola, Federica; Barbati, Cristiana; Morello, Francesca; Alfè, Michela; Di Blasio, Gabriele; Gargiulo, Valentina; Vomero, Marta; Conti, Fabrizio; Valesini, Guido. Diesel exhaust particles induce autophagy and citrullination in Normal Human Bronchial Epithelial cells. Cell Death & Disease. 2018;9(11):1073. 

Zaidi, Hani; Byrkjeland, Rune; Njerve, Ida U; Åkra, Sissel; Solheim, Svein; Arnesen, Harald; Seljeflot, Ingebjørg; Opstad, Trine B. Effects of exercise training on inflammasome-related mediators and their associations to glucometabolic variables in patients with combined coronary artery disease and type 2 diabetes mellitus: Sub-study of a randomized control trial. Diabetes & Vascular Disease Research. 2019;16(4):360-368. 

Tsuneto, Patrícia Yumeko; de Souza, Victor Hugo; de Alencar, Josiane Bazzo; Zacarias, Joana Maira Valentini; Silva, Cléverson O; Visentainer, Jeane Eliete Laguila; Sell, Ana Maria. IL18 Polymorphism and Periodontitis Susceptibility, Regardless of IL12B, MMP9, and Smoking Habits. Mediators Of Inflammation. 2019:9585964. 

Leu, Wohn-Jenn; Chen, Jui-Ching; Guh, Jih-Hwa. Extract From Plectranthus amboinicus Inhibit Maturation and Release of Interleukin 1β Through Inhibition of NF-κB Nuclear Translocation and NLRP3 Inflammasome Activation. Frontiers In Pharmacology. 10:573. 

Martínez-García, Juan José; Martínez-Banaclocha, Helios; Angosto-Bazarra, Diego; de Torre-Minguela, Carlos; Baroja-Mazo, Alberto; Alarcón-Vila, Cristina; Martínez-Alarcón, Laura; Amores-Iniesta, Joaquín; Martín-Sánchez, Fátima; Ercole, Giovanni A; Martínez, Carlos M; González-Lisorge, Ada; Fernández-Pacheco, José; Martínez-Gil, Piedad; Adriouch, Sahil; Koch-Nolte, Friedrich; Luján, Juan; Acosta-Villegas, Francisco; Parrilla, Pascual; García-Palenciano, Carlos; Pelegrin, Pablo. P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis. Nature Communications. 2019;10(1):2711. 
- Comments: Used in: ELISA

Limandjaja, Grace C; van den Broek, Leonarda J; Waaijman, Taco; Breetveld, Melanie; Monstrey, Stan; Scheper, Rik J; Niessen, Frank B; Gibbs, Susan. Reconstructed human keloid models show heterogeneity within keloid scars. Archives Of Dermatological Research. 2018;310(10):815-826. 
- Comments: Used in: ELISA

Matsuyama, Hisayo; Isshiki, Takuma; Chiba, Asako; Yamaguchi, Tetsuo; Murayama, Goh; Akasaka, Yoshikiyo; Eishi, Yoshinobu; Sakamoto, Susumu; Homma, Sakae; Miyake, Sachiko. Activation of mucosal-associated invariant T cells in the lungs of sarcoidosis patients. Scientific Reports. 2019;9(1):13181. 

Kim, Hwan Soo; Kim, Kyunghoon; Lee, Hyejin; Yang, Eun Ae; Chun, Yoon Hong; Kim, Hyun Hee; Kim, Jin Tack. Level of interleukin-18 binding protein is significantly different in patients with anaphylaxis than urticaria. Asian Pacific Journal Of Allergy And Immunology. 2022;40(4):368-373. 

Fatyga, Paulina; Pac, Agnieszka; Fedyk-Łukasik, Małgorzata; Grodzicki, Tomasz; Skalska, Anna. The relationship between malnutrition risk and inflammatory biomarkers in outpatient geriatric population. European Geriatric Medicine. 2020;11(3):383-391. 

Maida, Carlo Domenico; Vasto, Sonya; Di Raimondo, Domenico; Casuccio, Alessandra; Vassallo, Valerio; Daidone, Mario; Del Cuore, Alessandro; Pacinella, Gaetano; Cirrincione, Anna; Simonetta, Irene; Della Corte, Vittoriano; Rizzica, Salvatore; Geraci, Giulio; Tuttolomondo, Antonino; Pinto, Antonio. Inflammatory activation and endothelial dysfunction markers in patients with permanent atrial fibrillation: a cross-sectional study. Aging. 2020;12(9):8423-8433. 

Morimoto, Chie; Matsumoto, Hisako; Tajiri, Tomoko; Gon, Yasuhiro; Ito, Reiko; Hashimoto, Shu; Suzukawa, Maho; Ohta, Ken; Izuhara, Kenji; Ono, Junya; Ohta, Shoichiro; Ito, Isao; Oguma, Tsuyoshi; Kanemitsu, Yoshihiro; Nagasaki, Tadao; Izuhara, Yumi; Niimi, Akio; Hirai, Toyohiro. High serum free IL-18 is associated with decreased omalizumab efficacy: findings from a 2-year omalizumab treatment study. The Journal Of Asthma : Official Journal Of The Association For The Care Of Asthma. 2021;58(9):1133-1142. 

Felmerer, Gunther; Stylianaki, Aikaterini; Hägerling, Rene; Wang, Anna; Ströbel, Philipp; Hollmén, Maija; Lindenblatt, Nicole; Gousopoulos, Epameinondas. Adipose Tissue Hypertrophy, An Aberrant Biochemical Profile and Distinct Gene Expression in Lipedema. The Journal Of Surgical Research. 2020;253:294-303. 

McLeod, Daryl J; Sebastião, Yuri V; Ching, Christina B; Greenberg, Jason H; Furth, Susan L; Becknell, Brian. Longitudinal kidney injury biomarker trajectories in children with obstructive uropathy. Pediatric Nephrology (Berlin, Germany). 2020;35(10):1907-1914. 

Nishimura, Kenichi; Hara, Ryoki; Umebayashi, Hiroaki; Takei, Syuji; Iwata, Naomi; Imagawa, Tomoyuki; Shimizu, Masaki; Tomiita, Minako; Seko, Noriko; Kitawaki, Tetsuji; Yokota, Shumpei. Efficacy and safety of canakinumab in systemic juvenile idiopathic arthritis: 48-week results from an open-label phase III study in Japanese patients. Modern Rheumatology. 2021;31(1):226-234. 

Shang, Lin; Deng, Dongmei; Roffel, Sanne; Gibbs, Susan. Differential influence of Streptococcus mitis on host response to metals in reconstructed human skin and oral mucosa. Contact Dermatitis. 2020;83(5):347-360. 

Yamada, Kazuhisa; Kaneko, Hiroki; Shimizu, Hideyuki; Suzumura, Ayana; Namba, Rina; Takayama, Kei; Ito, Seina; Sugimoto, Masataka; Terasaki, Hiroko. Lamivudine Inhibits Alu RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities. Translational Vision Science & Technology. 2020;9(8):1. 

Krei, J M; Møller, H J; Larsen, J B. The role of interleukin-18 in the diagnosis and monitoring of hemophagocytic lymphohistiocytosis/macrophage activation syndrome - a systematic review. Clinical And Experimental Immunology. 2021;203(2):174-182. 

Wakiguchi, Hiroyuki; Okazaki, Fumiko; Suzuki, Yasuo; Ichimura, Takuya; Wakabayashi-Takahara, Midori; Terachi, Shin-Ichi; Ouchi, Kazunobu; Hasegawa, Shunji. Acute rheumatic fever associated with tenosynovitis and a unique cytokine profile. Immunological Medicine. 2018;41(1):43-45.