The α3 mutation significantly reduces the binding of MHC tetramer to human CD8. To minimizes the aberrant effect of some CD8 antibodies; clone SFCI21Thy2D3 (also known as “T8”) is recommended.
| Product Specifications | |
| Application | FC |
| Reactivity | Human |
| Conjugation | PE |
| Peptide Sequence | Tax 301-309 |
| Citations for HLA-A*24:02 HTLV-1 Tax 301-309 Tetramer-SFHSLHLLF-PE – 4 Found |
| Kozako, Tomohiro; Akimoto, Masaki; Toji, Shingo; White, Yohann; Suzuki, Susumu; Arima, Takehiro; Suruga, Yukio; Matsushita, Kakushi; Shimeno, Hiroshi; Soeda, Shinji; Kubota, Ryuji; Izumo, Shuji; Uozumi, Kimiharu; Arima, Naomichi. Target epitopes of HTLV-1 recognized by class I MHC-restricted cytotoxic T lymphocytes in patients with myelopathy and spastic paraparesis and infected patients with autoimmune disorders. Journal Of Medical Virology. 2011;83(3):501-9. PubMed |
| Ishihara, Yuko; Tanaka, Yukie; Kobayashi, Seiichiro; Kawamura, Koji; Nakasone, Hideki; Gomyo, Ayumi; Hayakawa, Jin; Tamaki, Masaharu; Akahoshi, Yu; Harada, Naonori; Kusuda, Machiko; Kameda, Kazuaki; Ugai, Tomotaka; Wada, Hidenori; Sakamoto, Kana; Sato, Miki; Terasako-Saito, Kiriko; Kikuchi, Misato; Kimura, Shun-Ichi; Tanihara, Aki; Kako, Shinichi; Uchimaru, Kaoru; Kanda, Yoshinobu. A Unique T-Cell Receptor Amino Acid Sequence Selected by Human T-Cell Lymphotropic Virus Type 1 Tax(301-309)-Specific Cytotoxic T Cells in HLA-A24:02-Positive Asymptomatic Carriers and Adult T-Cell Leukemia/Lymphoma Patients. Journal Of Virology. 2017;91(19) PubMed |
| Kawabata, Takashi; Higashimoto, Ikkou; Takashima, Hiroshi; Izumo, Shuji; Kubota, Ryuji. Human T-lymphotropic virus type I (HTLV-I)-specific CD8+ cells accumulate in the lungs of patients infected with HTLV-I with pulmonary involvement. Journal Of Medical Virology. 2012;84(7):1120-7. PubMed - Comments: Used in: IHC |
| Jo, Tatsuro; Kaneko, Yohei; Oishi, Takayuki; Matsuzaka, Kaori; Shioya, Haruna; Sakai, Takahiro; Tomoinaga, Hiroo; Hayashi, Shizuka; Matsuo, Masatoshi; Taguchi, Jun. Elevation of Memory Cytotoxic T Lymphocytes, Including Human T Lymphotropic Virus Type 1 Tax-Specific and Hepatitis Virus Type C-Specific Cytotoxic T Lymphocytes, in a Patient with Adult T-Cell Leukemia/Lymphoma and Hepatocellular Carcinoma. Case Reports In Oncology. 2020;13(2):802-806. PubMed - Comments: Used in: FCM |