The α3 mutation significantly reduces the binding of MHC tetramer to human CD8. To minimizes the aberrant effect of some CD8 antibodies; clone SFCI21Thy2D3 (also known as “T8”) is recommended.
| Product Specifications | |
| Application | FC |
| Reactivity | Human |
| Conjugation | PE |
| Peptide Sequence | LLGRNSFEV |
| Citations for HLA-A*02:01 p53 Tetramer-LLGRNSFEV-PE – 1 Found |
| Li, Zhi-Ling; Zhang, Hai-Liang; Huang, Yun; Huang, Jun-Hao; Sun, Peng; Zhou, Ning-Ning; Chen, Yu-Hong; Mai, Jia; Wang, Yan; Yu, Yan; Zhou, Li-Huan; Li, Xuan; Yang, Dong; Peng, Xiao-Dan; Feng, Gong-Kan; Tang, Jun; Zhu, Xiao-Feng; Deng, Rong. Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation. Nature Communications. 2020;11(1):3806. PubMed - Comments: Used in: FCM |