CircuLex Mouse/Rat PCSK9 ELISA Kit

Catalog No:
MBL-CY-8078

Availability: 12PM PT on Dec. 3, 2024

The CycLex Research Product CircuLex Mouse/Rat PCSK9 ELISA Kit is used for the quantitative measurement of Mouse and Rat PCSK9 in serum, plasma, cell culture medium and other biological media. It can be used for 96 Assays.

Product Specifications
Application ELISA
Sensitivity better than 38.1 pg/ml of sample.

Citations for CircuLex Mouse/Rat PCSK9 ELISA Kit – 22 Found
Chen, Xiao-Wei; Wang, He; Bajaj, Kanika; Zhang, Pengcheng; Meng, Zhuo-Xian; Ma, Danjun; Bai, Yongsheng; Liu, Hui-Hui; Adams, Elizabeth; Baines, Andrea; Yu, Genggeng; Sartor, Maureen A; Zhang, Bin; Yi, Zhengping; Lin, Jiandie; Young, Stephen G; Schekman, Randy; Ginsburg, David. SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. Elife. 2013;2:e00444.  PubMed
Carrier, Bradley; Wen, Shin; Zigouras, Sophia; Browne, Richard W; Li, Zhuyun; Patel, Mulchand S; Williamson, David L; Rideout, Todd C. Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese Zucker rats. Plos One. 9(3):e90863.  PubMed
Sasaki, Makoto; Terao, Yoshio; Ayaori, Makoto; Uto-Kondo, Harumi; Iizuka, Maki; Yogo, Makiko; Hagisawa, Kosuke; Takiguchi, Shunichi; Yakushiji, Emi; Nakaya, Kazuhiro; Ogura, Masatsune; Komatsu, Tomohiro; Ikewaki, Katsunori. Hepatic overexpression of idol increases circulating protein convertase subtilisin/kexin type 9 in mice and hamsters via dual mechanisms: sterol regulatory element-binding protein 2 and low-density lipoprotein receptor-dependent pathways. Arteriosclerosis, Thrombosis, And Vascular Biology. 2014;34(6):1171-8.  PubMed
Galabova, Gergana; Brunner, Sylvia; Winsauer, Gabriele; Juno, Claudia; Wanko, Bettina; Mairhofer, Andreas; Lührs, Petra; Schneeberger, Achim; von Bonin, Arne; Mattner, Frank; Schmidt, Walter; Staffler, Guenther. Peptide-based anti-PCSK9 vaccines - an approach for long-term LDLc management. Plos One. 9(12):e114469.  PubMed
Berger, Jean-Mathieu; Vaillant, Nathalie; Le May, Cédric; Calderon, Carolina; Brégeon, Jeremy; Prieur, Xavier; Hadchouel, Juliette; Loirand, Gervaise; Cariou, Bertrand. PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension. Atherosclerosis. 2015;239(1):252-9.  PubMed
Butkinaree, Chutikarn; Canuel, Maryssa; Essalmani, Rachid; Poirier, Steve; Benjannet, Suzanne; Asselin, Marie-Claude; Roubtsova, Anna; Hamelin, Josée; Marcinkiewicz, Jadwiga; Chamberland, Ann; Guillemot, Johann; Mayer, Gaétan; Sisodia, Sangram S; Jacob, Yves; Prat, Annik; Seidah, Nabil G. Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other. The Journal Of Biological Chemistry. 2015;290(30):18609-20.  PubMed
An, Dong; Wei, Xiaowei; Li, Hui; Gu, Hui; Huang, Tianchu; Zhao, Guifeng; Liu, Bo; Wang, Weilin; Chen, Lizhu; Ma, Wei; Zhang, Henan; Cao, Songying; Yuan, Zhengwei. Identification of PCSK9 as a novel serum biomarker for the prenatal diagnosis of neural tube defects using iTRAQ quantitative proteomics. Scientific Reports. 2015;5:17559.  PubMed
Haas, Mary E; Levenson, Amy E; Sun, Xiaowei; Liao, Wan-Hui; Rutkowski, Joseph M; de Ferranti, Sarah D; Schumacher, Valerie A; Scherer, Philipp E; Salant, David J; Biddinger, Sudha B. The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia. Circulation. 2016;134(1):61-72.  PubMed
Ngo Sock, Emilienne Tudor; Mayer, Gaétan; Lavoie, Jean-Marc. Combined Effects of Rosuvastatin and Exercise on Gene Expression of Key Molecules Involved in Cholesterol Metabolism in Ovariectomized Rats. Plos One. 11(7):e0159550.  PubMed
Lintner, Nathanael G; McClure, Kim F; Petersen, Donna; Londregan, Allyn T; Piotrowski, David W; Wei, Liuqing; Xiao, Jun; Bolt, Michael; Loria, Paula M; Maguire, Bruce; Geoghegan, Kieran F; Huang, Austin; Rolph, Tim; Liras, Spiros; Doudna, Jennifer A; Dullea, Robert G; Cate, Jamie H D. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. Plos Biology. 2017;15(3):e2001882.  PubMed
Xu, Yu-Xin; Redon, Valeska; Yu, Haojie; Querbes, William; Pirruccello, James; Liebow, Abigail; Deik, Amy; Trindade, Kevin; Wang, Xiao; Musunuru, Kiran; Clish, Clary B; Cowan, Chad; Fizgerald, Kevin; Rader, Daniel; Kathiresan, Sekar. Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol. Atherosclerosis. 2018;268:196-206.  PubMed
Yang, Sheng-Hua; Xu, Rui-Xia; Cui, Chuan-Jue; Wang, Yin; Du, Ying; Chen, Zhi-Guo; Yao, Yu-Hong; Ma, Chun-Yan; Zhu, Cheng-Gang; Guo, Yuan-Lin; Wu, Na-Qiong; Sun, Jing; Chen, Bu-Xing; Li, Jian-Jun. Liraglutide downregulates hepatic LDL receptor and PCSK9 expression in HepG2 cells and db/db mice through a HNF-1a dependent mechanism. Cardiovascular Diabetology. 2018;17(1):48.  PubMed
Ding, Zufeng; Wang, Xianwei; Liu, Shijie; Shahanawaz, Jiwani; Theus, Sue; Fan, Yubo; Deng, Xiaoyan; Zhou, Sichang; Mehta, Jawahar L. PCSK9 expression in the ischaemic heart and its relationship to infarct size, cardiac function, and development of autophagy. Cardiovascular Research. 2018;114(13):1738-1751.  PubMed
Liu, Yan; Wang, Xiaona; Han, Jie; Liu, Lu; Jin, Ying; Jin, Liyuan; Ye, Ping. PCSK9 positively correlates with plasma sdLDL in community-dwelling population but not in diabetic participants after confounder adjustment. Medicine. 2019;98(14):e15062.  PubMed
Momtazi-Borojeni, Amir Abbas; Nik, Maryam Ebrahimi; Jaafari, Mahmoud Reza; Banach, Maciej; Sahebkar, Amirhossein. Potential anti-tumor effect of a nanoliposomal antiPCSK9 vaccine in mice bearing colorectal cancer. Archives Of Medical Science : Ams. 2019;15(3):559-569.  PubMed
Momtazi-Borojeni, Amir Abbas; Nik, Maryam Ebrahimi; Jaafari, Mahmoud Reza; Banach, Maciej; Sahebkar, Amirhossein. Effects of immunization against PCSK9 in an experimental model of breast cancer. Archives Of Medical Science : Ams. 2019;15(3):570-579.  PubMed
Momtazi-Borojeni, Amir Abbas; Jaafari, Mahmoud Reza; Badiee, Ali; Banach, Maciej; Sahebkar, Amirhossein. Therapeutic effect of nanoliposomal PCSK9 vaccine in a mouse model of atherosclerosis. Bmc Medicine. 2019;17(1):223.  PubMed
Momtazi-Borojeni, Amir Abbas; Nik, Maryam Ebrahimi; Jaafari, Mahmoud Reza; Banach, Maciej; Sahebkar, Amirhossein. Effects of immunisation against PCSK9 in mice bearing melanoma. Archives Of Medical Science : Ams. 16(1):189-199.  PubMed
Low, Lauretta D; Lu, Liangjian; Chan, Chang-Yien; Chen, Jinmiao; Yang, Henry H; Yu, Hanry; Lee, Caroline G L; Ng, Kar-Hui; Yap, Hui-Kim. IL-13-driven alterations in hepatic cholesterol handling contributes to hypercholesterolemia in a rat model of minimal change disease. Clinical Science (London, England : 1979). 2020;134(2):225-237.  PubMed
Evison, Benny J; Palmer, James T; Lambert, Gilles; Treutlein, Herbert; Zeng, Jun; Nativel, Brice; Chemello, Kévin; Zhu, Qing; Wang, Jie; Teng, Yanfen; Tang, Wei; Xu, Yanfeng; Rathi, Anuj Kumar; Kumar, Sanjay; Suchowerska, Alexandra K; Parmar, Jasneet; Dixon, Ian; Kelly, Graham E; Bonnar, James. A small molecule inhibitor of PCSK9 that antagonizes LDL receptor binding via interaction with a cryptic PCSK9 binding groove. Bioorganic & Medicinal Chemistry. 2020;28(6):115344.  PubMed
St-Amand, Roxane; Ngo Sock, Émilienne T; Quinn, Samantha; Lavoie, Jean-Marc; St-Pierre, David H. Two weeks of western diet disrupts liver molecular markers of cholesterol metabolism in rats. Lipids In Health And Disease. 2020;19(1):192.  PubMed
Ding, Zufeng; Wang, Xianwei; Liu, Shijie; Zhou, Sichang; Kore, Rajshekhar A; Mu, Shengyu; Deng, Xiaoyan; Fan, Yubo; Mehta, Jawahar L. NLRP3 inflammasome via IL-1β regulates PCSK9 secretion. Theranostics. 10(16):7100-7110.  PubMed