Anti ZEB1 pAb (ATL-HPA027524 w/enhanced validation)

Atlas

Catalog No: ATL-HPA027524-25

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Application: ICC, IHC 
Clonality: Polyclonal 
Host: Rabbit 
Reactivity: Human 
Protein Description: zinc finger E-box binding homeobox 1
Gene Name: ZEB1
Alternative Gene Name: AREB6, BZP, FECD6, NIL-2-A, PPCD3, TCF8, ZEB, Zfhep, Zfhx1a
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000024238: 74%, ENSRNOG00000017863: 76%
Entrez Gene ID: 6935
Uniprot ID: P37275
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Citations for Anti ZEB1 pAb (ATL-HPA027524 w/enhanced validation) – 95 Found

The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors.
Oncotarget. 2015 Jun 10;6(16):14399-412. doi: 10.18632/oncotarget.3882. 

EMT-associated factors promote invasive properties of uveal melanoma cells.
Mol Vis. 2015 Aug 25;21:919-29. eCollection 2015. 

Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach.
Cell Death Dis. 2016 Feb 4;7(2):e2087. doi: 10.1038/cddis.2016.7. 

Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition.
Elife. 2016 May 14;5:e12717. doi: 10.7554/eLife.12717. 

Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer.
Oncotarget. 2016 Aug 16;7(33):53430-53442. doi: 10.18632/oncotarget.10802. 

Loss of ZFP36 expression in colorectal cancer correlates to wnt/ ß-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of ZEB1, SOX9 and MACC1.
Oncotarget. 2016 Sep 13;7(37):59144-59157. doi: 10.18632/oncotarget.10828. 

Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells.
Oncotarget. 2016 Nov 8;7(45):73414-73431. doi: 10.18632/oncotarget.12337. 

Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts.
EMBO Mol Med. 2017 Jul;9(7):918-932. doi: 10.15252/emmm.201607354. 

Cellular heterogeneity contributes to subtype-specific expression of ZEB1 in human glioblastoma.
PLoS One. 2017 Sep 25;12(9):e0185376. doi: 10.1371/journal.pone.0185376. eCollection 2017. 

Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles.
EMBO J. 2017 Nov 15;36(22):3336-3355. doi: 10.15252/embj.201797345. Epub 2017 Oct 16. 

ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming.
J Clin Invest. 2018 Jan 2;128(1):323-340. doi: 10.1172/JCI93815. Epub 2017 Nov 27. 

Distinguishing mechanisms underlying EMT tristability.
Cancer Converg. 2017;1(1):2. doi: 10.1186/s41236-017-0005-8. Epub 2017 Nov 1. 

Zeb1 potentiates genome-wide gene transcription with Lef1 to promote glioblastoma cell invasion.
EMBO J. 2018 Aug 1;37(15):e97115. doi: 10.15252/embj.201797115. Epub 2018 Jun 14. 

Caspase-independent cell death does not elicit a proliferative response in melanoma cancer cells.
BMC Cell Biol. 2018 Jul 4;19(1):11. doi: 10.1186/s12860-018-0164-1. 

PAR1 signaling on tumor cells limits tumor growth by maintaining a mesenchymal phenotype in pancreatic cancer.
Oncotarget. 2018 Aug 10;9(62):32010-32023. doi: 10.18632/oncotarget.25880. eCollection 2018 Aug 10. 

Clinical Impact of Epithelial-to-Mesenchymal Transition Regulating MicroRNAs in Pancreatic Ductal Adenocarcinoma.
Cancers (Basel). 2018 Sep 13;10(9):328. doi: 10.3390/cancers10090328. 

Regulation of muscle atrophy-related genes by the opposing transcriptional activities of ZEB1/CtBP and FOXO3.
Nucleic Acids Res. 2018 Nov 16;46(20):10697-10708. doi: 10.1093/nar/gky835. 

ACVR1C/SMAD2 signaling promotes invasion and growth in retinoblastoma.
Oncogene. 2019 Mar;38(12):2056-2075. doi: 10.1038/s41388-018-0543-2. Epub 2018 Nov 6. 

EMT induced by loss of LKB1 promotes migration and invasion of liver cancer cells through ZEB1-induced YAP signaling.
Oncol Lett. 2018 Nov;16(5):6465-6471. doi: 10.3892/ol.2018.9445. Epub 2018 Sep 18. 

The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.
Cell Mol Gastroenterol Hepatol. 2018 Sep 11;7(1):33-53. doi: 10.1016/j.jcmgh.2018.08.007. eCollection 2019. 

Carcinosarcoma of the esophagus: A report of 6 cases associated with zinc finger E-box-binding homeobox 1 expression.
Oncol Lett. 2019 Jan;17(1):578-586. doi: 10.3892/ol.2018.9585. Epub 2018 Oct 16. 

ZEB1 protects skeletal muscle from damage and is required for its regeneration.
Nat Commun. 2019 Mar 25;10(1):1364. doi: 10.1038/s41467-019-08983-8. 

Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer.
APL Bioeng. 2018 Aug 22;2(3):031908. doi: 10.1063/1.5024874. eCollection 2018 Sep. 

Hyaluronic acid synthase 2 promotes malignant phenotypes of colorectal cancer cells through transforming growth factor beta signaling.
Cancer Sci. 2019 Jul;110(7):2226-2236. doi: 10.1111/cas.14070. Epub 2019 Jun 12. 

Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity.
Life Sci Alliance. 2019 Jul 22;2(4):e201900425. doi: 10.26508/lsa.201900425. Print 2019 Aug. 

HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer.
Oncogenesis. 2019 Aug 20;8(9):45. doi: 10.1038/s41389-019-0158-7. 

Downregulation of Nodal inhibits metastatic progression in retinoblastoma.
Acta Neuropathol Commun. 2019 Aug 26;7(1):137. doi: 10.1186/s40478-019-0785-4. 

Immunohistochemistry-Based Consensus Molecular Subtypes as a Prognostic and Predictive Biomarker for Adjuvant Chemotherapy in Patients with Stage II Colorectal Cancer.
Oncologist. 2020 Dec;25(12):e1968-e1979. doi: 10.1002/ONCO.13521. Epub 2020 Sep 28. 

Functional Hierarchy and Cooperation of EMT Master Transcription Factors in Breast Cancer Metastasis.
Mol Cancer Res. 2021 May;19(5):784-798. doi: 10.1158/1541-7786.MCR-20-0532. Epub 2021 Jan 26. 

MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer.
NPJ Breast Cancer. 2021 May 27;7(1):64. doi: 10.1038/s41523-021-00273-1. 

ELK3 Mediated by ZEB1 Facilitates the Growth and Metastasis of Pancreatic Carcinoma by Activating the Wnt/β-Catenin Pathway.
Front Cell Dev Biol. 2021 Aug 2;9:700192. doi: 10.3389/fcell.2021.700192. eCollection 2021. 

Overexpression of Cystine/Glutamate Antiporter xCT Correlates with Nutrient Flexibility and ZEB1 Expression in Highly Clonogenic Glioblastoma Stem-like Cells (GSCs).
Cancers (Basel). 2021 Nov 29;13(23):6001. doi: 10.3390/cancers13236001. 

A Multi-Omics Network of a Seven-Gene Prognostic Signature for Non-Small Cell Lung Cancer.
Int J Mol Sci. 2021 Dec 25;23(1):219. doi: 10.3390/ijms23010219. 

Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits.
Commun Biol. 2022 Jan 11;5(1):41. doi: 10.1038/s42003-021-02934-0. 

Overexpression of ZEB1 associated with metastasis and invasion in patients with gastric carcinoma.
Mol Cell Biochem. 2012 Jul;366(1-2):223-9. doi: 10.1007/s11010-012-1299-6. Epub 2012 Mar 31. 

Quantitative analysis of microRNAs in tissue microarrays by in situ hybridization.
Biotechniques. 2012 Apr;52(4):235-45. doi: 10.2144/000113837. 

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions.
Nat Med. 2013 May;19(5):614-8. doi: 10.1038/nm.3174. Epub 2013 Apr 14. 

Zeb1 regulates E-cadherin and Epcam (epithelial cell adhesion molecule) expression to control cell behavior in early zebrafish development.
J Biol Chem. 2013 Jun 28;288(26):18643-59. doi: 10.1074/jbc.M113.467787. Epub 2013 May 10. 

The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells.
Int J Oncol. 2013 Aug;43(2):548-60. doi: 10.3892/ijo.2013.1963. Epub 2013 May 27. 

Epithelial to mesenchymal transition in murine tracheal allotransplantation: an immunohistochemical observation.
Transplant Proc. 2013 Jun;45(5):1797-801. doi: 10.1016/j.transproceed.2012.11.024. 

Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in breast cancer.
J Biol Chem. 2013 Aug 9;288(32):22993-3008. doi: 10.1074/jbc.M113.456293. Epub 2013 Jun 29. 

Direct RNA sequencing mediated identification of mRNA localized in protrusions of human MDA-MB-231 metastatic breast cancer cells.
J Mol Signal. 2013 Sep 1;8(1):9. doi: 10.1186/1750-2187-8-9. 

Activation of miR200 by c-Myb depends on ZEB1 expression and miR200 promoter methylation.
Cell Cycle. 2013 Jul 15;12(14):2309-20. doi: 10.4161/cc.25405. 

Transcription factors OVOL1 and OVOL2 induce the mesenchymal to epithelial transition in human cancer.
PLoS One. 2013 Oct 4;8(10):e76773. doi: 10.1371/journal.pone.0076773. eCollection 2013. 

Epithelial-mesenchymal transition induces endoplasmic-reticulum-stress response in human colorectal tumor cells.
PLoS One. 2014 Jan 31;9(1):e87386. doi: 10.1371/journal.pone.0087386. eCollection 2014. 

CD95 and CD95L promote and protect cancer stem cells.
Nat Commun. 2014 Nov 4;5:5238. doi: 10.1038/ncomms6238. 

The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions.
Hum Pathol. 2015 Jan;46(1):1-8. doi: 10.1016/j.humpath.2014.10.004. Epub 2014 Oct 16. 

Radiation promotes malignant phenotypes through SRC in breast cancer cells.
Cancer Sci. 2015 Jan;106(1):78-85. doi: 10.1111/cas.12574. Epub 2014 Dec 23. 

ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat.
EMBO Mol Med. 2015 Jun;7(6):831-47. doi: 10.15252/emmm.201404396. 

The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5.
Oncotarget. 2015 Sep 29;6(29):27083-96. doi: 10.18632/oncotarget.4807. 

Expression of zinc finger E-box-binding homeobox factor 1 in epithelial ovarian cancer: A clinicopathological analysis of 238 patients.
Mol Clin Oncol. 2016 Jan;4(1):18-22. doi: 10.3892/mco.2015.662. Epub 2015 Oct 23. 

ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types.
Nat Commun. 2016 Feb 15;7:10498. doi: 10.1038/ncomms10498. 

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype.
EMBO Mol Med. 2016 Jul 1;8(7):745-60. doi: 10.15252/emmm.201606184. Print 2016 Jul. 

Resetting cancer stem cell regulatory nodes upon MYC inhibition.
EMBO Rep. 2016 Dec;17(12):1872-1889. doi: 10.15252/embr.201541489. Epub 2016 Nov 16. 

A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer.
Oncotarget. 2017 Feb 14;8(7):11530-11543. doi: 10.18632/oncotarget.14563. 

Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition.
BMC Cancer. 2017 Jul 17;17(1):487. doi: 10.1186/s12885-017-3472-5. 

Phytosphingosine exhibits an anti-epithelial-mesenchymal transition function by the inhibition of EGFR signaling in human breast cancer cells.
Oncotarget. 2017 Sep 8;8(44):77794-77808. doi: 10.18632/oncotarget.20783. eCollection 2017 Sep 29. 

Deficiency of protein-L-isoaspartate (D-aspartate) O-methyl-transferase expression under endoplasmic reticulum stress promotes epithelial mesenchymal transition in lung adenocarcinoma.
Oncotarget. 2018 Jan 27;9(17):13287-13300. doi: 10.18632/oncotarget.24324. eCollection 2018 Mar 2. 

Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor.
Mol Cancer Res. 2018 Dec;16(12):1952-1964. doi: 10.1158/1541-7786.MCR-18-0135. Epub 2018 Aug 6. 

Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression.
Mol Cancer Res. 2019 Jan;17(1):30-41. doi: 10.1158/1541-7786.MCR-18-0246. Epub 2018 Sep 13. 

Infiltrative and drug-resistant slow-cycling cells support metabolic heterogeneity in glioblastoma.
EMBO J. 2018 Dec 3;37(23):e98772. doi: 10.15252/embj.201798772. Epub 2018 Oct 15. 

Cancer-associated stroma significantly contributes to the mesenchymal subtype signature of serous ovarian cancer.
Gynecol Oncol. 2019 Feb;152(2):368-374. doi: 10.1016/j.ygyno.2018.11.014. Epub 2018 Nov 15. 

Early-stage serrated adenocarcinomas are divided into several molecularly distinct subtypes.
PLoS One. 2019 Feb 20;14(2):e0211477. doi: 10.1371/journal.pone.0211477. eCollection 2019. 

PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance.
Diagn Pathol. 2019 Oct 26;14(1):120. doi: 10.1186/s13000-019-0901-6. 

Hypoxia-induced HIF-1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF-β-dependent EMT.
Cancer Med. 2019 Dec;8(18):7822-7832. doi: 10.1002/cam4.2667. Epub 2019 Nov 1. 

Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-β signalling: implications for PAH vascular remodelling.
Cell Commun Signal. 2019 Nov 8;17(1):143. doi: 10.1186/s12964-019-0449-9. 

Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma.
Cancer Res. 2020 Apr 1;80(7):1461-1474. doi: 10.1158/0008-5472.CAN-19-2578. Epub 2020 Feb 6. 

OVOL2-Mediated ZEB1 Downregulation May Prevent Promotion of Actinic Keratosis to Cutaneous Squamous Cell Carcinoma.
J Clin Med. 2020 Feb 25;9(3):618. doi: 10.3390/jcm9030618. 

High-grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF-1.
EMBO Rep. 2020 May 6;21(5):e48780. doi: 10.15252/embr.201948780. Epub 2020 Mar 16. 

RUNX1 and RUNX2 transcription factors function in opposing roles to regulate breast cancer stem cells.
J Cell Physiol. 2020 Oct;235(10):7261-7272. doi: 10.1002/jcp.29625. Epub 2020 Mar 17. 

A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity.
Cell Death Discov. 2020 Apr 16;6:20. doi: 10.1038/s41420-020-0258-3. eCollection 2020. 

Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer.
J Exp Med. 2020 Sep 7;217(9):e20200388. doi: 10.1084/jem.20200388. 

Tumor-Suppressive miR-192-5p Has Prognostic Value in Pancreatic Ductal Adenocarcinoma.
Cancers (Basel). 2020 Jun 25;12(6):1693. doi: 10.3390/cancers12061693. 

Possible reversibility between epithelioid and sarcomatoid types of mesothelioma is independent of ERC/mesothelin expression.
Respir Res. 2020 Jul 16;21(1):187. doi: 10.1186/s12931-020-01449-2. 

Genome-wide cooperation of EMT transcription factor ZEB1 with YAP and AP-1 in breast cancer.
EMBO J. 2020 Sep 1;39(17):e103209. doi: 10.15252/embj.2019103209. Epub 2020 Jul 21. 

New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer.
Cancers (Basel). 2020 Jul 18;12(7):1952. doi: 10.3390/cancers12071952. 

EphA2, a possible target of miR-200a, functions through the AKT2 pathway in human lung carcinoma.
Int J Clin Exp Pathol. 2020 Aug 1;13(8):2201-2210. eCollection 2020. 

Soluble Compounds Released by Hypoxic Stroma Confer Invasive Properties to Pancreatic Ductal Adenocarcinoma.
Biomedicines. 2020 Oct 22;8(11):444. doi: 10.3390/biomedicines8110444. 

Enzymatic Activity of CD73 Modulates Invasion of Gliomas via Epithelial-Mesenchymal Transition-Like Reprogramming.
Pharmaceuticals (Basel). 2020 Nov 11;13(11):378. doi: 10.3390/ph13110378. 

MEK1 Inhibitor Combined with Irradiation Reduces Migration of Breast Cancer Cells Including miR-221 and ZEB1 EMT Marker Expression.
Cancers (Basel). 2020 Dec 14;12(12):3760. doi: 10.3390/cancers12123760. 

Expression of Selected Epithelial-Mesenchymal Transition Transcription Factors in Endometrial Cancer.
Biomed Res Int. 2020 Dec 29;2020:4584250. doi: 10.1155/2020/4584250. eCollection 2020. 

Molecular Analysis of ZNF71 KRAB in Non-Small-Cell Lung Cancer.
Int J Mol Sci. 2021 Apr 4;22(7):3752. doi: 10.3390/ijms22073752. 

Nuclear Syndecan-1 Regulates Epithelial-Mesenchymal Plasticity in Tumor Cells.
Biology (Basel). 2021 Jun 11;10(6):521. doi: 10.3390/biology10060521. 

Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS/MAPK pathway activation.
Breast Cancer Res. 2022 Jan 25;24(1):8. doi: 10.1186/s13058-022-01501-7. 

PD-L1 as a Prognostic Factor in Early-Stage Colon Carcinoma within the Immunohistochemical Molecular Subtype Classification.
Cancers (Basel). 2021 Apr 17;13(8):1943. doi: 10.3390/cancers13081943. 

Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer.
Elife. 2021 May 26;10:e61461. doi: 10.7554/eLife.61461. 

PINX1 promotes malignant transformation of thyroid cancer through the activation of the AKT/MAPK/β-catenin signaling pathway.
Am J Cancer Res. 2021 Nov 15;11(11):5485-5495. eCollection 2021. 

Fibroblast activation protein identifies Consensus Molecular Subtype 4 in colorectal cancer and allows its detection by (68)Ga-FAPI-PET imaging.
Br J Cancer. 2022 Jul;127(1):145-155. doi: 10.1038/s41416-022-01748-z. Epub 2022 Mar 16. 

Micro-RNA-215 and -375 regulate thymidylate synthase protein expression in pleural mesothelioma and mediate epithelial to mesenchymal transition.
Virchows Arch. 2022 Aug;481(2):233-244. doi: 10.1007/s00428-022-03321-8. Epub 2022 Apr 24. 

HDAC8-Selective Inhibition by PCI-34051 Enhances the Anticancer Effects of ACY-241 in Ovarian Cancer Cells.
Int J Mol Sci. 2022 Aug 3;23(15):8645. doi: 10.3390/ijms23158645. 

Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging.
Nat Commun. 2022 Sep 9;13(1):5317. doi: 10.1038/s41467-022-32958-x. 

A novel gene signature unveils three distinct immune-metabolic rewiring patterns conserved across diverse tumor types and associated with outcomes.
Front Immunol. 2022 Sep 2;13:926304. doi: 10.3389/fimmu.2022.926304. eCollection 2022. 

Molecular and clinicopathological differences between depressed and protruded T2 colorectal cancer.
PLoS One. 2022 Oct 20;17(10):e0273566. doi: 10.1371/journal.pone.0273566. eCollection 2022. 

SHH and Notch regulate SOX9+ progenitors to govern arcuate POMC neurogenesis.
Front Neurosci. 2022 Aug 11;16:855288. doi: 10.3389/fnins.2022.855288. eCollection 2022. 

An in vivo avian model of human melanoma to perform rapid and robust preclinical studies.
EMBO Mol Med. 2023 Mar 8;15(3):e16629. doi: 10.15252/emmm.202216629. Epub 2023 Jan 24.