Monoclonal Antibody of 100 μg targeting XIAP for IHC, WB.
| Product Specifications | |
| Application | WB, IHC |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal IgG1 |
| Host | Mouse |
| Immunogen | Full-length recombinant human XIAP protein |
| Gene ID - Human | |
| Gene ID - Mouse | |
| Formulation | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Citations for Anti-XIAP (MIHA/ILP-a) (Human) mAb (Clone: 2F1) – 16 Found |
| Ferreira, C G; van der Valk, P; Span, S W; Jonker, J M; Postmus, P E; Kruyt, F A; Giaccone, G. Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients. Annals Of Oncology : Official Journal Of The European Society For Medical Oncology. 2001;12(6):799-805. PubMed - Comments: Used in: IHC |
| Ferreira, C G; van der Valk, P; Span, S W; Ludwig, I; Smit, E F; Kruyt, F A; Pinedo, H M; van Tinteren, H; Giaccone, G. Expression of X-linked inhibitor of apoptosis as a novel prognostic marker in radically resected non-small cell lung cancer patients. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research. 2001;7(8):2468-74. PubMed - Comments: Used in: IHC |
| Bilim, Vladimir; Kasahara, Takashi; Hara, Noboru; Takahashi, Kota; Tomita, Yoshihiko. Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro. International Journal Of Cancer. 2003;103(1):29-37. PubMed - Comments: Used in: IHC |
| Silke, John; Kratina, Tobias; Ekert, Paul G; Pakusch, Miha; Vaux, David L. Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis. The Journal Of Biological Chemistry. 2004;279(6):4313-21. PubMed - Comments: Used in: WB |
| Muris, Jettie J F; Cillessen, Saskia A G M; Vos, Wim; van Houdt, Inge S; Kummer, J Alain; van Krieken, Johan H J M; Jiwa, N Mehdi; Jansen, Patty M; Kluin-Nelemans, Hanneke C; Ossenkoppele, Gert J; Gundy, Chad; Meijer, Chris J L M; Oudejans, Joost J. Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas. Blood. 2005;105(7):2916-23. PubMed - Comments: Used in: IHC |
| Tanaka, Hiroshi; Fujita, Naoya; Tsuruo, Takashi. 3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling. The Journal Of Biological Chemistry. 2005;280(49):40965-73. PubMed - Comments: Used in: WB |
| Silke, John; Kratina, Tobias; Chu, Diep; Ekert, Paul G; Day, Catherine L; Pakusch, Miha; Huang, David C S; Vaux, David L. Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2005;102(45):16182-7. PubMed - Comments: Used in: WB |
| Marsden, Vanessa S; Kaufmann, Thomas; O'reilly, Lorraine A; Adams, Jerry M; Strasser, Andreas. Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death. Blood. 2006;107(5):1872-7. PubMed - Comments: Used in: WB |
| Cillessen, Saskia A G M; Hess, Corine J; Hooijberg, Erik; Castricum, Kitty C M; Kortman, Pim; Denkers, Fedor; Vos, Wim; van de Wiel, Mark A; Schuurhuis, Gerrit J; Ossenkoppele, Gert J; Meijer, Chris J L M; Oudejans, Joost J. Inhibition of the intrinsic apoptosis pathway downstream of caspase-9 activation causes chemotherapy resistance in diffuse large B-cell lymphoma. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research. 2007;13(23):7012-21. PubMed - Comments: Used in: WB |
| Cillessen, Saskia A G M; Hess, Corine J; Hooijberg, Erik; Castricum, Kitty C M; Kortman, Pim; Denkers, Fedor; Vos, Wim; van de Wiel, Mark A; Schuurhuis, Gerrit J; Ossenkoppele, Gert J; Meijer, Chris J L M; Oudejans, Joost J. Inhibition of the intrinsic apoptosis pathway downstream of caspase-9 activation causes chemotherapy resistance in diffuse large B-cell lymphoma. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research. 2007;13(23):7012-21. PubMed - Comments: Used in: IHC |
| Smith, Michelle I; Huang, Yolanda Y; Deshmukh, Mohanish. Skeletal muscle differentiation evokes endogenous XIAP to restrict the apoptotic pathway. Plos One. 4(3):e5097. PubMed - Comments: Used in: WB |
| Verzola, Daniela; Ratto, Elena; Villaggio, Barbara; Parodi, Emanuele Luigi; Pontremoli, Roberto; Garibotto, Giacomo; Viazzi, Francesca. Uric acid promotes apoptosis in human proximal tubule cells by oxidative stress and the activation of NADPH oxidase NOX 4. Plos One. 9(12):e115210. PubMed - Comments: Used in: WB |
| Ishikawa, Chie; Senba, Masachika; Mori, Naoki. Mitotic kinase PBK/TOPK as a therapeutic target for adult T‑cell leukemia/lymphoma. International Journal Of Oncology. 2018;53(2):801-814. PubMed - Comments: Used in: WB |
| Vince, James E; De Nardo, Dominic; Gao, Wenqing; Vince, Angelina J; Hall, Cathrine; McArthur, Kate; Simpson, Daniel; Vijayaraj, Swarna; Lindqvist, Lisa M; Bouillet, Philippe; Rizzacasa, Mark A; Man, Si Ming; Silke, John; Masters, Seth L; Lessene, Guillaume; Huang, David C S; Gray, Daniel H D; Kile, Benjamin T; Shao, Feng; Lawlor, Kate E. The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation. Cell Reports. 2018;25(9):2339-2353.e4. PubMed - Comments: Used in: WB |
| Ishikawa, Chie; Senba, Masachika; Mori, Naoki. Evaluation of artesunate for the treatment of adult T-cell leukemia/lymphoma. European Journal Of Pharmacology. 2020;872:172953. PubMed - Comments: Used in: WB |
| Lalaoui, Najoua; Merino, Delphine; Giner, Goknur; Vaillant, François; Chau, Diep; Liu, Lin; Kratina, Tobias; Pal, Bhupinder; Whittle, James R; Etemadi, Nima; Berthelet, Jean; Gräsel, Julius; Hall, Cathrine; Ritchie, Matthew E; Ernst, Matthias; Smyth, Gordon K; Vaux, David L; Visvader, Jane E; Lindeman, Geoffrey J; Silke, John. Targeting triple-negative breast cancers with the Smac-mimetic birinapant. Cell Death And Differentiation. 2020;27(10):2768-2780. PubMed - Comments: Used in: WB |