Application: WB, ICC, IHC
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human, Mouse, Rat
Protein Description: ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Gene Name: UCHL1
Alternative Gene Name: PARK5, PGP9.5, Uch-L1
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000029223: 97%, ENSRNOG00000002343: 97%
Entrez Gene ID: 7345
Uniprot ID: P09936
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human, Mouse, Rat
Protein Description: ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Gene Name: UCHL1
Alternative Gene Name: PARK5, PGP9.5, Uch-L1
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000029223: 97%, ENSRNOG00000002343: 97%
Entrez Gene ID: 7345
Uniprot ID: P09936
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
| Cognate Antibody/Antigen for Anti UCHL1 pAb (ATL-HPA005993 w/enhanced validation) | |
| Antigen | PrEST Antigen UCHL1 (ATL-APrEST86224) |
| Documents & Links for Anti UCHL1 pAb (ATL-HPA005993 w/enhanced validation) | |
| Datasheet | Anti UCHL1 pAb (ATL-HPA005993 w/enhanced validation) Datasheet (External Link) |
| Vendor Page | Anti UCHL1 pAb (ATL-HPA005993 w/enhanced validation) at Atlas |
| Documents & Links for Anti UCHL1 pAb (ATL-HPA005993 w/enhanced validation) | |
| Datasheet | Anti UCHL1 pAb (ATL-HPA005993 w/enhanced validation) Datasheet (External Link) |
| Vendor Page | Anti UCHL1 pAb (ATL-HPA005993 w/enhanced validation) |
| Citations for Anti UCHL1 pAb (ATL-HPA005993 w/enhanced validation) – 21 Found |
| The prognostic potential and oncogenic effects of PRR11 expression in hilar cholangiocarcinoma. Oncotarget. 2015 Aug 21;6(24):20419-33. doi: 10.18632/oncotarget.3983. PubMed |
| UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization. Sci Rep. 2017 Jul 31;7(1):6879. doi: 10.1038/s41598-017-06605-1. PubMed |
| Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells. mBio. 2019 Jul 16;10(4):e01372-19. doi: 10.1128/mBio.01372-19. PubMed |
| MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate. Cancer Cell. 2020 Jul 13;38(1):60-78.e12. doi: 10.1016/j.ccell.2020.05.001. Epub 2020 May 30. PubMed |
| Genetic Determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo. Cancer Discov. 2021 Jul;11(7):1736-1753. doi: 10.1158/2159-8290.CD-20-1385. Epub 2021 Mar 11. PubMed |
| ASCL1 represses a SOX9(+) neural crest stem-like state in small cell lung cancer. Genes Dev. 2021 Jun;35(11-12):847-869. doi: 10.1101/gad.348295.121. Epub 2021 May 20. PubMed |
| Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W. Nat Commun. 2021 Jul 29;12(1):4608. doi: 10.1038/s41467-021-24669-6. PubMed |
| A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs. Nat Commun. 2022 May 16;13(1):2690. doi: 10.1038/s41467-022-30416-2. PubMed |
| Antibody-based proteomics for discovery and exploration of proteins expressed in pancreatic islets. Discov Med. 2010 Jun;9(49):565-78. PubMed |
| UCH-LI acts as a novel prognostic biomarker in gastric cardiac adenocarcinoma. Int J Clin Exp Pathol. 2015 Nov 1;8(11):13957-67. eCollection 2015. PubMed |
| Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer. Genes Dev. 2016 Jun 1;30(11):1289-99. doi: 10.1101/gad.279307.116. PubMed |
| Xenografting of isolated equine (Equus caballus) testis cells results in de novo morphogenesis of seminiferous tubules but not spermatogenesis. Andrology. 2017 Mar;5(2):336-346. doi: 10.1111/andr.12308. Epub 2017 Feb 3. PubMed |
| Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer. Nature. 2017 May 18;545(7654):360-364. doi: 10.1038/nature22323. Epub 2017 May 10. PubMed |
| Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition. Cancer Discov. 2018 Nov;8(11):1422-1437. doi: 10.1158/2159-8290.CD-18-0385. Epub 2018 Sep 4. PubMed |
| Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin. Cancer Discov. 2018 Oct;8(10):1316-1331. doi: 10.1158/2159-8290.CD-17-0987. Epub 2018 Sep 18. PubMed |
| Axon-like protrusions promote small cell lung cancer migration and metastasis. Elife. 2019 Dec 13;8:e50616. doi: 10.7554/eLife.50616. PubMed |
| Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Promotes Uterine Serous Cancer Cell Proliferation and Cell Cycle Progression. Cancers (Basel). 2020 Jan 2;12(1):118. doi: 10.3390/cancers12010118. PubMed |
| Prognostic potential and oncogenic effects of UCH-L1 expression in hilar cholangiocarcinoma. Int J Clin Exp Pathol. 2017 Nov 1;10(11):10802-10811. eCollection 2017. PubMed |
| Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18. PubMed |
| Combinatorial Inactivation of Tumor Suppressors Efficiently Initiates Lung Adenocarcinoma with Therapeutic Vulnerabilities. Cancer Res. 2022 Apr 15;82(8):1589-1602. doi: 10.1158/0008-5472.CAN-22-0059. PubMed |
| A multiplexed in vivo approach to identify driver genes in small cell lung cancer. Cell Rep. 2023 Jan 31;42(1):111990. doi: 10.1016/j.celrep.2023.111990. Epub 2023 Jan 13. PubMed |