Anti-Txnip (VDUP1) (Human) mAb (Clone: JY2)

MBL

Catalog No: MBL-K0205-3

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Thioredoxin (TRX)-binding protein (Txnip), also called Vitamin D3 up-regulated protein 1 (VDUP1) is an endogenous inhibitor of TRX. Monoclonal Antibody of 100 μg targeting VDUP-1/Txnip for IHC, IPP, WB.

Product Specifications

• Application: IP, WB, IHC
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal IgG1
• Host: Mouse
• Immunogen: Recombinant human Txnip/VDUP1
• Formulation: 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Citations for Anti-Txnip (VDUP1) (Human) mAb (Clone: JY2) – 27 Found

Yoshioka, Jun; Imahashi, Kenichi; Gabel, Scott A; Chutkow, William A; Burds, Aurora A; Gannon, Joseph; Schulze, P Christian; MacGillivray, Catherine; London, Robert E; Murphy, Elizabeth; Lee, Richard T. Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload. Circulation Research. 2007;101(12):1328-38. 
- Comments: Used in: WB

Chen, Junqin; Saxena, Geetu; Mungrue, Imran N; Lusis, Aldons J; Shalev, Anath. Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes. 2008;57(4):938-44. 
- Comments: Used in: WB

Pang, See-Tong; Hsieh, Wen-Chi; Chuang, Cheng-Keng; Chao, Chun-Hsiang; Weng, Wen-Hui; Juang, Horng-Heng. Thioredoxin-interacting protein: an oxidative stress-related gene is upregulated by glucose in human prostate carcinoma cells. Journal Of Molecular Endocrinology. 2009;42(3):205-14. 

Chen, Junqin; Cha-Molstad, Hyunjoo; Szabo, Anna; Shalev, Anath. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein. American Journal Of Physiology. Endocrinology And Metabolism. 2009;296(5):E1133-9. 
- Comments: Used in: WB

Patwari, Parth; Chutkow, William A; Cummings, Kiersten; Verstraeten, Valerie L R M; Lammerding, Jan; Schreiter, Eric R; Lee, Richard T. Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins. The Journal Of Biological Chemistry. 2009;284(37):24996-5003. 
- Comments: Used in: WB

Saxena, Geetu; Chen, Junqin; Shalev, Anath. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. The Journal Of Biological Chemistry. 2010;285(6):3997-4005. 
- Comments: Used in: WB

Saxena, Geetu; Chen, Junqin; Shalev, Anath. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. The Journal Of Biological Chemistry. 2010;285(6):3997-4005. 
- Comments: Used in: IHC

Hand, Laura E; Saer, Ben R C; Hui, Simon T; Jinnah, Hyder A; Steinlechner, Stephan; Loudon, Andrew S I; Bechtold, David A. Induction of the metabolic regulator Txnip in fasting-induced and natural torpor. Endocrinology. 2013;154(6):2081-91. 
- Comments: Used in: IHC

Kibbe, Carly; Chen, Junqin; Xu, Guanlan; Jing, Gu; Shalev, Anath. FOXO1 competes with carbohydrate response element-binding protein (ChREBP) and inhibits thioredoxin-interacting protein (TXNIP) transcription in pancreatic beta cells. The Journal Of Biological Chemistry. 2013;288(32):23194-202. 
- Comments: Used in: WB

Morrison, Jennifer A; Pike, Laura A; Sams, Sharon B; Sharma, Vibha; Zhou, Qiong; Severson, Jill J; Tan, Aik-Choon; Wood, William M; Haugen, Bryan R. Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor in thyroid cancer. Molecular Cancer. 2014;13:62. 
- Comments: Used in: IHC

Jing, Gu; Westwell-Roper, Clara; Chen, Junqin; Xu, Guanlan; Verchere, C Bruce; Shalev, Anath. Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through miR-124a and FoxA2. The Journal Of Biological Chemistry. 2014;289(17):11807-11815. 
- Comments: Used in: WB

Hong, Kyunghee; Xu, Guanlan; Grayson, Truman B; Shalev, Anath. Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways. The Journal Of Biological Chemistry. 2016;291(16):8428-39. 
- Comments: Used in: WB

Ahn, Byungyong; Soundarapandian, Mangala M; Sessions, Hampton; Peddibhotla, Satyamaheshwar; Roth, Gregory P; Li, Jian-Liang; Sugarman, Eliot; Koo, Ada; Malany, Siobhan; Wang, Miao; Yea, Kyungmoo; Brooks, Jeanne; Leone, Teresa C; Han, Xianlin; Vega, Rick B; Kelly, Daniel P. MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. The Journal Of Clinical Investigation. 2016;126(9):3567-79. 
- Comments: Used in: WB

Hulmi, Juha J; Hentilä, Jaakko; DeRuisseau, Keith C; Oliveira, Bernardo M; Papaioannou, Konstantinos G; Autio, Reija; Kujala, Urho M; Ritvos, Olli; Kainulainen, Heikki; Korkmaz, Ayhan; Atalay, Mustafa. Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress. Free Radical Biology & Medicine. 2016;99:308-322. 
- Comments: Used in: WB

Du, Ren-Hong; Wu, Fang-Fang; Lu, Ming; Shu, Xiao-Dong; Ding, Jian-Hua; Wu, Guangyu; Hu, Gang. Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression. Redox Biology. 2016;9:178-187. 
- Comments: Used in: WB

Jung, Haiyoung; Kim, Dong Oh; Byun, Jae-Eun; Kim, Won Sam; Kim, Mi Jeong; Song, Hae Young; Kim, Young Kwan; Kang, Du-Kyeong; Park, Young-Jun; Kim, Tae-Don; Yoon, Suk Ran; Lee, Hee Gu; Choi, Eun-Ji; Min, Sang-Hyun; Choi, Inpyo. Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity. Nature Communications. 2016;7:13674. 
- Comments: Used in: ICC

Coucha, Maha; Mohamed, Islam N; Elshaer, Sally L; Mbata, Osinakachuk; Bartasis, Megan L; El-Remessy, Azza B. High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress. World Journal Of Diabetes. 2017;8(2):56-65. 
- Comments: Used in: WB

Morita, Shuhei; Villalta, S Armando; Feldman, Hannah C; Register, Ames C; Rosenthal, Wendy; Hoffmann-Petersen, Ingeborg T; Mehdizadeh, Morvarid; Ghosh, Rajarshi; Wang, Likun; Colon-Negron, Kevin; Meza-Acevedo, Rosa; Backes, Bradley J; Maly, Dustin J; Bluestone, Jeffrey A; Papa, Feroz R. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metabolism. 2017;25(4):883-897.e8. 
- Comments: Used in: WB

Park, Sangkyu; Park, Jeong-A; Yoo, Hwanmin; Park, Han-Bum; Lee, Younghee. Proteasome inhibitor-induced cleavage of HSP90 is mediated by ROS generation and caspase 10-activation in human leukemic cells. Redox Biology. 2017;13:470-476. 
- Comments: Used in: WB

Hoshikawa, Hiroshi; Kamitori, Kazuyo; Indo, Kanako; Mori, Terushige; Kamata, Mizuna; Takahashi, Tomoko; Tokuda, Masaaki. Combined treatment with D-allose, docetaxel and radiation inhibits the tumor growth in an in vivo model of head and neck cancer. Oncology Letters. 2018;15(3):3422-3428. 
- Comments: Used in: WB

Belaya, Irina; Suwa, Masataka; Chen, Tao; Giniatullin, Rashid; Kanninen, Katja M; Atalay, Mustafa; Kumagai, Shuzo. Long-Term Exercise Protects against Cellular Stresses in Aged Mice. Oxidative Medicine And Cellular Longevity. 2018:2894247. 
- Comments: Used in: WB

Panse, Madhura; Kluth, Oliver; Lorza-Gil, Estela; Kaiser, Gabriele; Mühlbauer, Eckhard; Schürmann, Annette; Häring, Hans-Ulrich; Ullrich, Susanne; Gerst, Felicia. Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms. Plos One. 13(5):e0198016. 
- Comments: Used in: WB

Gunes, Aysim; Bagirsakci, Ezgi; Iscan, Evin; Cakan-Akdogan, Gulcin; Aykutlu, Umut; Senturk, Serif; Ozhan, Gunes; Erdal, Esra; Nart, Deniz; Barbet, Funda Yilmaz; Atabey, Nese. Thioredoxin interacting protein promotes invasion in hepatocellular carcinoma. Oncotarget. 2018;9(96):36849-36866. 
- Comments: Used in: WB

Danzl, Katarina; Messner, Barbara; Doppler, Christian; Nebert, Clemens; Abfalterer, Anna; Sakic, Adel; Temml, Veronika; Heinz, Katharina; Streitwieser, Robert; Edelmann, Thomas; Mairhofer, Mario; Grimm, Michael; Laufer, Günther; Zierer, Andreas; Stuppner, Hermann; Schuster, Daniela; Ploner, Christian; Müller, Thomas; Bernhard, David. Early inhibition of endothelial retinoid uptake upon myocardial infarction restores cardiac function and prevents cell, tissue, and animal death. Journal Of Molecular And Cellular Cardiology. 2019;126:105-117. 
- Comments: Used in: WB

Levring, Trine B; Kongsbak-Wismann, Martin; Rode, Anna K O; Al-Jaberi, Fatima A H; Lopez, Daniel V; Met, Özcan; Woetmann, Anders; Bonefeld, Charlotte M; Ødum, Niels; Geisler, Carsten. Tumor necrosis factor induces rapid down-regulation of TXNIP in human T cells. Scientific Reports. 2019;9(1):16725. 
- Comments: Used in: WB

Ishibashi, Tatsuya; Morita, Shuhei; Kishimoto, Shohei; Uraki, Shinsuke; Takeshima, Ken; Furukawa, Yasushi; Inaba, Hidefumi; Ariyasu, Hiroyuki; Iwakura, Hiroshi; Furuta, Hiroto; Nishi, Masahiro; Papa, Feroz R; Akamizu, Takashi. Nicotinic acetylcholine receptor signaling regulates inositol-requiring enzyme 1α activation to protect β-cells against terminal unfolded protein response under irremediable endoplasmic reticulum stress. Journal Of Diabetes Investigation. 2020;11(4):801-813. 
- Comments: Used in: WB

Danzl, Katarina; Messner, Barbara; Doppler, Christian; Nebert, Clemens; Abfalterer, Anna; Sakic, Adel; Temml, Veronika; Heinz, Katharina; Streitwieser, Robert; Edelmann, Thomas; Mairhofer, Mario; Grimm, Michael; Laufer, Günther; Zierer, Andreas; Stuppner, Hermann; Schuster, Daniela; Ploner, Christian; Müller, Thomas; Bernhard, David. Early inhibition of endothelial retinoid uptake upon myocardial infarction restores cardiac function and prevents cell, tissue, and animal death. Journal Of Molecular And Cellular Cardiology. 2019;126:105-117. 
- Comments: Used in: IHC