Application: WB, IHC, ELISA
Clonality: Monoclonal
Purification: Purified - Affinity
Reactivity: Human
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
Clonality: Monoclonal
Purification: Purified - Affinity
Reactivity: Human
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
| Documents & Links for Anti TP63 mAb (Clone 4B3) | |
| Datasheet | Anti TP63 mAb (Clone 4B3) Datasheet |
| Vendor Page | Anti TP63 mAb (Clone 4B3) at CUSABIO |
| Documents & Links for Anti TP63 mAb (Clone 4B3) | |
| Datasheet | Anti TP63 mAb (Clone 4B3) Datasheet |
| Vendor Page | Anti TP63 mAb (Clone 4B3) |
