Anti Drosophila FACT Complex Subunit Spt16 (dSPT16/DRE4) pAb (Rabbit, Antiserum)

Cosmo Bio LTD

Catalog No: CAC-NIG-L1-SHA2

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Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.

FACT (Facilitates Chromatin Transcription) is a protein complex involved in chromatin remodeling and comprises two subunits, SSRP1 and SPT16. A recent Drosophila study suggested that FACT forms a complex with a DNA binding protein, GAGA factor, to regulate sequence-specific changes in chromatin structure. SSRP1 and SPT16 have come to be noted as important new factors linking FACT and GAGA factors.

dSPT16 is the Drosophila ortholog of SPT16. Studies hve revealed that dSPT16 facilitates various chromatin transactions such as transcriptional regulation, DNA replication and histone replacement. This antibody against dSPT16 is a powerful tool for Western blots (Ref.1), immunostaining (Ref.2), immunoprecipitation and chromatin immunopreciptation (Ref.1,2,3).

Source: Dr. Susumu Hirose, National Institute of Genetics

References:
1) Shimojima, T. et al. , (2003) Genes & Dev . 17, 1605-1616.
2) Saunders, A. et al. , (2003) Science , 301, 1094-1096.
3) Nakayama, T. et al. , (2007) Genes & Dev . 21, 552-561.