Anti SIX1 pAb (ATL-HPA001893 w/enhanced validation)

Atlas Antibodies

Catalog No: ATL-HPA001893-25

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Product Description

Protein Description: SIX homeobox 1
Gene Name: SIX1
Alternative Gene Name: DFNA23
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000051367: 99%, ENSRNOG00000022777: 99%
Entrez Gene ID: 6495
Uniprot ID: Q15475
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Product Specifications

• Application: WB, ICC, IHC
• Reactivity: Human
• Clonality: Polyclonal
• Host: Rabbit
• Immunogen: CFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNSSSNKQNQLSPLEGGKPLMSSSEEEFSPPQSPDQNSVLLLQGNMGHARSSNYSLPGLTASQPSHGLQTHQHQLQDS
• Gene Sequence: CFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNSSSNKQNQLSPLEGGKPLMSSSEEEFSPPQSPDQNSVLLLQGNMGHARSSNYSLPGLTASQPSHGLQTHQHQLQDS
• Gene ID - Mouse: ENSMUSG00000051367
• Gene ID - Rat: ENSRNOG00000022777
• Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.

Citations

Citations for Anti SIX1 pAb (ATL-HPA001893 w/enhanced validation) – 34 Found

Simões-Costa, Marcos; Stone, Michael; Bronner, Marianne E. Axud1 Integrates Wnt Signaling and Transcriptional Inputs to Drive Neural Crest Formation. Developmental Cell. 2015;34(5):544-54. 

Adrados, I; Larrasa-Alonso, J; Galarreta, A; López-Antona, I; Menéndez, C; Abad, M; Gil, J; Moreno-Bueno, G; Palmero, I. The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes. Oncogene. 2016;35(27):3485-94. 

Suen, Alisa A; Jefferson, Wendy N; Wood, Charles E; Padilla-Banks, Elizabeth; Bae-Jump, Victoria L; Williams, Carmen J. SIX1 Oncoprotein as a Biomarker in a Model of Hormonal Carcinogenesis and in Human Endometrial Cancer. Molecular Cancer Research : Mcr. 2016;14(9):849-58. 

Sun, Shu-Hua; Liu, Dan; Deng, Yun-Te; Zhang, Xiao-Xue; Wan, Dong-Yi; Xi, Bi-Xin; Huang, Wei; Chen, Qian; Li, Meng-Chen; Wang, Ming-Wei; Yang, Fei; Shu, Ping; Wu, Ke-Zhi; Gao, Qing-Lei. SIX1 coordinates with TGFβ signals to induce epithelial-mesenchymal transition in cervical cancer. Oncology Letters. 2016;12(2):1271-1278. 

Sakakibara, Iori; Wurmser, Maud; Dos Santos, Matthieu; Santolini, Marc; Ducommun, Serge; Davaze, Romain; Guernec, Anthony; Sakamoto, Kei; Maire, Pascal. Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle. Skeletal Muscle. 6(1):30. 

Roellig, Daniela; Tan-Cabugao, Johanna; Esaian, Sevan; Bronner, Marianne E. Dynamic transcriptional signature and cell fate analysis reveals plasticity of individual neural plate border cells. Elife. 2017;6( 28355135) 

Zhang, Xiaojun; Xu, Ruxiang. Six1 expression is associated with a poor prognosis in patients with glioma. Oncology Letters. 2017;13(3):1293-1298. 

Chao, Lemeng; Liu, Jianfeng; Zhao, Dewei. Increased Six1 expression is associated with poor prognosis in patients with osteosarcoma. Oncology Letters. 2017;13(5):2891-2896. 

Tchieu, Jason; Zimmer, Bastian; Fattahi, Faranak; Amin, Sadaf; Zeltner, Nadja; Chen, Shuibing; Studer, Lorenz. A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages. Cell Stem Cell. 2017;21(3):399-410.e7. 

Zhang, Ting; Xu, Jinshu; Maire, Pascal; Xu, Pin-Xian. Six1 is essential for differentiation and patterning of the mammalian auditory sensory epithelium. Plos Genetics. 2017;13(9):e1006967. 

Fonseca, Barbara F; Couly, Gérard; Dupin, Elisabeth. Respective contribution of the cephalic neural crest and mesoderm to SIX1-expressing head territories in the avian embryo. Bmc Developmental Biology. 2017;17(1):13. 

Zhang, Lingdi; Zhou, Hengbo; Li, Xueni; Vartuli, Rebecca L; Rowse, Michael; Xing, Yongna; Rudra, Pratyaydipta; Ghosh, Debashis; Zhao, Rui; Ford, Heide L. Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression. Nature Communications. 2018;9(1):1047. 

De Lope, Cristina; Martín-Alonso, Samara; Auzmendi-Iriarte, Jaione; Escudero, Carmen; Mulet, Isabel; Larrasa-Alonso, Javier; López-Antona, Irene; Matheu, Ander; Palmero, Ignacio. SIX1 represses senescence and promotes SOX2-mediated cellular plasticity during tumorigenesis. Scientific Reports. 2019;9(1):1412. 

Adachi, Yuichiro; Masuda, Masashi; Sakakibara, Iori; Uchida, Takayuki; Niida, Yuki; Mori, Yuki; Kamei, Yuki; Okumura, Yosuke; Ohminami, Hirokazu; Ohnishi, Kohta; Yamanaka-Okumura, Hisami; Nikawa, Takeshi; Taketani, Yutaka. All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal. Life Science Alliance. 2022;5(7) 

Wan, Fang; Miao, Xijiang; Quraishi, Iram; Kennedy, Valerie; Creek, Kim E; Pirisi, Lucia. Gene expression changes during HPV-mediated carcinogenesis: a comparison between an in vitro cell model and cervical cancer. International Journal Of Cancer. 2008;123(1):32-40. 

McCoy, Erica L; Iwanaga, Ritsuko; Jedlicka, Paul; Abbey, Nee-Shamo; Chodosh, Lewis A; Heichman, Karen A; Welm, Alana L; Ford, Heide L. Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition. The Journal Of Clinical Investigation. 2009;119(9):2663-77. 

Micalizzi, Douglas S; Christensen, Kimberly L; Jedlicka, Paul; Coletta, Ricardo D; Barón, Anna E; Harrell, J Chuck; Horwitz, Kathryn B; Billheimer, Dean; Heichman, Karen A; Welm, Alana L; Schiemann, William P; Ford, Heide L. The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling. The Journal Of Clinical Investigation. 2009;119(9):2678-90. 

Farabaugh, S M; Micalizzi, D S; Jedlicka, P; Zhao, R; Ford, H L. Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties. Oncogene. 2012;31(5):552-62. 

Ono, H; Imoto, I; Kozaki, K; Tsuda, H; Matsui, T; Kurasawa, Y; Muramatsu, T; Sugihara, K; Inazawa, J. SIX1 promotes epithelial-mesenchymal transition in colorectal cancer through ZEB1 activation. Oncogene. 2012;31(47):4923-34. 

Smith, A L; Iwanaga, R; Drasin, D J; Micalizzi, D S; Vartuli, R L; Tan, A-C; Ford, H L. The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer. Oncogene. 2012;31(50):5162-71. 

Iwanaga, Ritsuko; Wang, Chu-An; Micalizzi, Douglas S; Harrell, J Chuck; Jedlicka, Paul; Sartorius, Carol A; Kabos, Peter; Farabaugh, Susan M; Bradford, Andrew P; Ford, Heide L. Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways. Breast Cancer Research : Bcr. 2012;14(4):R100. 

Le Grand, Fabien; Grifone, Raphaëlle; Mourikis, Philippos; Houbron, Christophe; Gigaud, Carine; Pujol, Julien; Maillet, Marjorie; Pagès, Gilles; Rudnicki, Michael; Tajbakhsh, Shahragim; Maire, Pascal. Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration. The Journal Of Cell Biology. 2012;198(5):815-32. 

Jefferson, Wendy N; Chevalier, Dominique M; Phelps, Jazma Y; Cantor, Amy M; Padilla-Banks, Elizabeth; Newbold, Retha R; Archer, Trevor K; Kinyamu, H Karimi; Williams, Carmen J. Persistently altered epigenetic marks in the mouse uterus after neonatal estrogen exposure. Molecular Endocrinology (Baltimore, Md.). 2013;27(10):1666-77. 

Koehler, Karl R; Hashino, Eri. 3D mouse embryonic stem cell culture for generating inner ear organoids. Nature Protocols. 9(6):1229-44. 

Sakakibara, Iori; Santolini, Marc; Ferry, Arnaud; Hakim, Vincent; Maire, Pascal. Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype. Plos Genetics. 10(5):e1004386. 

Kong, Jienan; Zhou, Xianchun; Liu, Shusen; Jin, Tiefeng; Piao, Yingshi; Liu, Chao; Lin, Zhenhua. Overexpression of sineoculis homeobox homolog 1 predicts poor prognosis of hepatocellular carcinoma. International Journal Of Clinical And Experimental Pathology. 7(6):3018-27. 

Towers, Christina G; Guarnieri, Anna L; Micalizzi, Doug S; Harrell, J Chuck; Gillen, Austin E; Kim, Jihye; Wang, Chu-An; Oliphant, Michael U J; Drasin, David J; Guney, Michelle A; Kabos, Peter; Sartorius, Carol A; Tan, Aik-Choon; Perou, Charles M; Espinosa, Joaquin M; Ford, Heide L. The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p. Nature Communications. 2015;6( 26687066):10077. 

Xu, Hanxiao; Bai, Xianguang; Yu, Shengnan; Liu, Qian; Pestell, Richard G; Wu, Kongming. MAT1 correlates with molecular subtypes and predicts poor survival in breast cancer. Chinese Journal Of Cancer Research = Chung-Kuo Yen Cheng Yen Chiu. 2018;30(3):351-363. 

Prasad, Maneeshi S; Uribe-Querol, Eileen; Marquez, Jonathan; Vadasz, Stephanie; Yardley, Nathan; Shelar, Patrick B; Charney, Rebekah M; García-Castro, Martín I. Blastula stage specification of avian neural crest. Developmental Biology. 2020;458(1):64-74. 

Li, Jun; Zhang, Ting; Ramakrishnan, Aarthi; Fritzsch, Bernd; Xu, Jinshu; Wong, Elaine Y M; Loh, Yong-Hwee Eddie; Ding, Jianqiang; Shen, Li; Xu, Pin-Xian. Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium. Nucleic Acids Research. 2020;48(6):2880-2896. 

Terakawa, Jumpei; Serna, Vanida A; Nair, Devi M; Sato, Shigeru; Kawakami, Kiyoshi; Radovick, Sally; Maire, Pascal; Kurita, Takeshi. SIX1 cooperates with RUNX1 and SMAD4 in cell fate commitment of Müllerian duct epithelium. Cell Death And Differentiation. 2020;27(12):3307-3320. 

Leonard, Carrie E; Quiros, Jolie; Lefcort, Frances; Taneyhill, Lisa A. Loss of Elp1 disrupts trigeminal ganglion neurodevelopment in a model of familial dysautonomia. Elife. 2022;11( 35713404) 

Li, Jun; Xu, Jinshu; Jiang, Huihui; Zhang, Ting; Ramakrishnan, Aarthi; Shen, Li; Xu, Pin-Xian. Chromatin Remodelers Interact with Eya1 and Six2 to Target Enhancers to Control Nephron Progenitor Cell Maintenance. Journal Of The American Society Of Nephrology : Jasn. 2021;32(11):2815-2833. 

Girgis, John; Yang, Dabo; Chakroun, Imane; Liu, Yubing; Blais, Alexandre. Six1 promotes skeletal muscle thyroid hormone response through regulation of the MCT10 transporter. Skeletal Muscle. 2021;11(1):26.