Anti SDHB pAb (ATL-HPA002868 w/enhanced validation)

Atlas

Catalog No: ATL-HPA002868-25

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Application: WB, ICC, IHC 
Clonality: Polyclonal 
Host: Rabbit 
Reactivity: Human, Mouse, Rat 
Protein Description: succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Gene Name: SDHB
Alternative Gene Name: SDH, SDH1
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000009863: 97%, ENSRNOG00000007967: 97%
Entrez Gene ID: 6390
Uniprot ID: P21912
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Citations for Anti SDHB pAb (ATL-HPA002868 w/enhanced validation) – 32 Found

Tyrosine kinase receptors as molecular targets in pheochromocytomas and paragangliomas.
Mod Pathol. 2014 Aug;27(8):1050-62. doi: 10.1038/modpathol.2013.233. Epub 2014 Jan 3. 

Deciphering the molecular basis of invasiveness in Sdhb-deficient cells.
Oncotarget. 2015 Oct 20;6(32):32955-65. doi: 10.18632/oncotarget.5106. 

NDUFAF5 Hydroxylates NDUFS7 at an Early Stage in the Assembly of Human Complex I.
J Biol Chem. 2016 Jul 8;291(28):14851-60. doi: 10.1074/jbc.M116.734970. Epub 2016 May 18. 

IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas.
Clin Sarcoma Res. 2017 May 4;7:8. doi: 10.1186/s13569-017-0074-6. eCollection 2017. 

Validation of pathological grading systems for predicting metastatic potential in pheochromocytoma and paraganglioma.
PLoS One. 2017 Nov 8;12(11):e0187398. doi: 10.1371/journal.pone.0187398. eCollection 2017. 

Metabolome-guided genomics to identify pathogenic variants in isocitrate dehydrogenase, fumarate hydratase, and succinate dehydrogenase genes in pheochromocytoma and paraganglioma.
Genet Med. 2019 Mar;21(3):705-717. doi: 10.1038/s41436-018-0106-5. Epub 2018 Jul 27. 

The loss of succinate dehydrogenase B expression is frequently identified in hemangioblastoma of the central nervous system.
Sci Rep. 2019 Apr 10;9(1):5873. doi: 10.1038/s41598-019-42338-z. 

Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model.
J Cell Mol Med. 2021 Aug;25(15):7407-7417. doi: 10.1111/jcmm.16769. Epub 2021 Jul 5. 

Androgen-Dependent Prostate Cancer Cells Reprogram Their Metabolic Signature upon GLUT1 Upregulation by Manganese Superoxide Dismutase.
Antioxidants (Basel). 2022 Feb 4;11(2):313. doi: 10.3390/antiox11020313. 

An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis.
Lancet Oncol. 2009 Aug;10(8):764-71. doi: 10.1016/S1470-2045(09)70164-0. Epub 2009 Jul 1. 

The Warburg effect is genetically determined in inherited pheochromocytomas.
PLoS One. 2009 Sep 18;4(9):e7094. doi: 10.1371/journal.pone.0007094. 

SDHA is a tumor suppressor gene causing paraganglioma.
Hum Mol Genet. 2010 Aug 1;19(15):3011-20. doi: 10.1093/hmg/ddq206. Epub 2010 May 18. 

A non-catecholamine-producing sympathetic paraganglioma of the spermatic cord: the importance of performing candidate gene mutation analysis.
Virchows Arch. 2010 Nov;457(5):619-22. doi: 10.1007/s00428-010-0966-9. Epub 2010 Sep 15. 

SDHB immunohistochemistry: a useful tool in the diagnosis of Carney-Stratakis and Carney triad gastrointestinal stromal tumors.
Mod Pathol. 2011 Jan;24(1):147-51. doi: 10.1038/modpathol.2010.185. Epub 2010 Oct 1. 

Sumo1-ylation of human spermatozoa and its relationship with semen quality.
Int J Androl. 2011 Dec;34(6 Pt 1):581-93. doi: 10.1111/j.1365-2605.2010.01118.x. Epub 2010 Oct 6. 

Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH?
J Clin Endocrinol Metab. 2012 Mar;97(3):E357-66. doi: 10.1210/jc.2011-1179. Epub 2011 Dec 14. 

Mitochondrial function and content in pheochromocytoma/paraganglioma of succinate dehydrogenase mutation carriers.
Endocr Relat Cancer. 2012 May 3;19(3):261-9. doi: 10.1530/ERC-11-0263. Print 2012 Jun. 

Analysis of all subunits, SDHA, SDHB, SDHC, SDHD, of the succinate dehydrogenase complex in KIT/PDGFRA wild-type GIST.
Eur J Hum Genet. 2014 Jan;22(1):32-9. doi: 10.1038/ejhg.2013.80. Epub 2013 Apr 24. 

A MEN1 syndrome with a paraganglioma.
Eur J Hum Genet. 2014 Feb;22(2):283-5. doi: 10.1038/ejhg.2013.128. Epub 2013 Jun 19. 

Aberrant DNA hypermethylation of SDHC: a novel mechanism of tumor development in Carney triad.
Endocr Relat Cancer. 2014 Aug;21(4):567-77. doi: 10.1530/ERC-14-0254. Epub 2014 May 23. 

Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST).
BMC Cancer. 2014 Sep 20;14:685. doi: 10.1186/1471-2407-14-685. 

Paraganglioma and pheochromocytoma upon maternal transmission of SDHD mutations.
BMC Med Genet. 2014 Oct 10;15:111. doi: 10.1186/s12881-014-0111-8. 

C11orf83, a mitochondrial cardiolipin-binding protein involved in bc1 complex assembly and supercomplex stabilization.
Mol Cell Biol. 2015 Apr;35(7):1139-56. doi: 10.1128/MCB.01047-14. Epub 2015 Jan 20. 

Urinary Bladder Paragangliomas: How Immunohistochemistry Can Assist to Identify Patients With SDHB Germline and Somatic Mutations.
Am J Surg Pathol. 2015 Nov;39(11):1488-92. doi: 10.1097/PAS.0000000000000534. 

Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models.
Oncotarget. 2016 Jun 28;7(26):40531-40545. doi: 10.18632/oncotarget.9643. 

MITF controls the TCA cycle to modulate the melanoma hypoxia response.
Pigment Cell Melanoma Res. 2019 Nov;32(6):792-808. doi: 10.1111/pcmr.12802. Epub 2019 Jul 8. 

Mutations in NDUFS1 Cause Metabolic Reprogramming and Disruption of the Electron Transfer.
Cells. 2019 Sep 25;8(10):1149. doi: 10.3390/cells8101149. 

Genetic Profile of Indian Pheochromocytoma and Paraganglioma Patients - A Single Institutional Study.
Indian J Endocrinol Metab. 2019 Jul-Aug;23(4):486-490. doi: 10.4103/ijem.IJEM_163_19. 

Metabolomics, machine learning and immunohistochemistry to predict succinate dehydrogenase mutational status in phaeochromocytomas and paragangliomas.
J Pathol. 2020 Aug;251(4):378-387. doi: 10.1002/path.5472. Epub 2020 Jul 1. 

Familial wild-type gastrointestinal stromal tumour in association with germline truncating variants in both SDHA and PALB2.
Eur J Hum Genet. 2021 Jul;29(7):1139-1145. doi: 10.1038/s41431-021-00862-5. Epub 2021 Apr 15. 

Computerized tomography texture analysis of pheochromocytoma: relationship with hormonal and histopathological data.
J Endocrinol Invest. 2022 Oct;45(10):1935-1944. doi: 10.1007/s40618-022-01826-2. Epub 2022 Jun 10. 

Expanded genetic testing of GIST patients identifies high proportion of non-syndromic patients with germline alterations.
NPJ Precis Oncol. 2023 Jan 2;7(1):1. doi: 10.1038/s41698-022-00342-z.